New rapid bed‐side test to predict preterm delivery: phosphorylated insulin‐like growth factor binding protein‐1 in cervical secretions

Lembet, Arda; Eroğlu, Derya; Ergin, Tolga; Kuşçu, Esra; Zeyneloglu, Hulusi Bulent; Batıoğlu, Sertaç; Haberal, Alı

doi:10.1034/j.1600-0412.2002.810804.x

Cited by 64 publications

(53 citation statements)

References 15 publications

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“…A total of 43 studies, including 10,203 women, met the inclusion criteria, of which nine provided data on asymptomatic women (n=6131), 36-44 28 on symptomatic women (n=3212), 18,45-71 and six on both asymptomatic (n=452) and symptomatic (n=408) women. 17,72-76 …”

Section: Resultsmentioning

confidence: 99%

“…Twenty studies (47%) were performed in European countries, 16 (37%) in Asia, three (7%) in South America, and four (9%) in Canada. The sample size ranged from 18 72 to 4984 40 (median, 88) in asymptomatic women and from 30 57 to 350 69 (median, 70) in symptomatic women. Among the 34 studies performed in symptomatic women, only seven (21%) defined preterm labor as the presence of uterine contractions with evidence of cervical changes.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Cervical phosphorylated insulin-like growth factor binding protein-1 test for the prediction of preterm birth: a systematic review and metaanalysis

Conde-Agudelo

Romero

2016

American Journal of Obstetrics and Gynecology

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OBJECTIVE To assess the accuracy of the cervical phosphorylated insulin-like growth factor binding protein-1 (phIGFBP-1) test to predict preterm birth in women with and without symptoms of preterm labor through use of formal methods for systematic reviews and meta-analytic techniques. DATA SOURCES PubMed, Embase, Cinahl, Lilacs, and Medion (all from inception to June 20, 2015), reference lists, conference proceedings, and Google scholar. STUDY ELIGIBILITY CRITERIA Cohort or cross-sectional studies that reported on the predictive accuracy of cervical phIGFBP-1 test for preterm birth. STUDY APPRAISAL AND SYNTHESIS METHODS Two reviewers independently selected studies, assessed risk of bias, and extracted data. Summary receiver operating characteristic curves, pooled sensitivities and specificities, and summary likelihood ratios were generated. RESULTS Forty-three studies met the inclusion criteria of which 15 provided data on asymptomatic women (n=6583) and 34 on women with an episode of preterm labor (N=3620). Among asymptomatic women, the predictive accuracy of cervical phIGFBP-1 test for preterm birth at <37, <34 and <32 weeks of gestation was minimal with pooled sensitivities and specificities, and summary positive and negative likelihood ratios ranging from 14-47%, 76-93%, 1.5-4.4, and 0.6-1.0, respectively. Among women with an episode of preterm labor, the test had a low predictive performance for delivery within 7 and 14 days of testing, and preterm birth at <34 and <37 weeks of gestation with pooled sensitivities and specificities, and summary positive and negative likelihood ratios that varied between 60 and 68%, 77 and 81%, 2.7 and 3.5, and 0.4 and 0.5, respectively. A negative test result in women with an episode of preterm labor had a low to moderate accuracy to identify women who are not at risk for delivering within the next 48 hours (summary negative likelihood ratio of 0.28 in all women and 0.23 in women with singleton gestations). CONCLUSION Cervical phIGFBP-1 has potential utility to identify patients with an episode of preterm labor who will not deliver within 48 hours. However, its overall predictive ability for the identification of symptomatic and asymptomatic women at risk for preterm birth is limited.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Cervical phosphorylated insulin-like growth factor binding protein-1 test for the prediction of preterm birth: a systematic review and metaanalysis

Conde-Agudelo

Romero

2016

American Journal of Obstetrics and Gynecology

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“…It leaks into cervical secretions when fetal membranes detach from decidua. Studies have shown that a bedside rapid strip test (Actim Partus Test) for detection of IGFBP-1 in cervical secretions provides an additional diagnostic tool for the assessment of patients presenting with preterm labour [26, 27]. In another study in which cervicovaginal sample was collected at 22-23 weeks, IGFBP-1 > 6.4 µ g/L had a likelihood ratio of +1.8 (95% CI 0.7–2.9) [10].…”

Section: Discussionmentioning

confidence: 99%

“…Efforts to predict preterm delivery have classically been based on history and examination findings only. But these risk assessment scores have poor predictive values [2, 3]. Some studies have found cervical length as measured by transvaginal ultrasound and cervicovaginal IGFBP-1 as most strongly and consistently associated with subsequent spontaneous preterm birth [4].…”

Section: Introductionmentioning

confidence: 99%

Can Preterm Labour Be Predicted in Low Risk Pregnancies? Role of Clinical, Sonographic, and Biochemical Markers

Tripathi

Tyagi

Singh

et al. 2014

Journal of Pregnancy

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Background and Objectives. This is a prospective nested cohort study conducted over a period of 3 years. 2644 women were recruited, out of which final analysis was done for 1884 women. Methods. Cervicovaginal and blood samples were collected for all recruited women. Out of these, 137 women who delivered before 35 weeks were treated as cases and equal number of matched controls were chosen. Analysis of samples for serum G-CSF, AFP, ferritin, and cervicovaginal interleukin-6 and IGFBP-1 was done. Results. Poor orodental hygiene, which can be a social marker, was significantly more common in women who delivered preterm (P = 0.008). Serum alkaline phosphatase and serum ferritin were found to be significantly associated with preterm deliveries. The 90th percentile value of these parameters was considered as cut-off as there is no specific cut-off. Conclusions. Our study did not prove usefulness of any predictive marker. Serum ferritin and alkaline phosphatase were found to have correlation but their values are affected in many conditions and need to be elucidated with caution. Larger studies are needed for predicting preterm labour in asymptomatic women.

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“…In addition, measurement of phIGFBP-1 from cervical secretions can also be used to estimate the ripeness of the cervix [138]. Lembet et al [139] show that for women between 20 and 36 weeks gestation, that phIGFBP-1 has a PPV of 83.3% and a NPV of 94.1% for predicting delivery within 7 days and thus is a useful test for the assessment of the likelihood of preterm delivery.…”

Section: Insulin-like Growth Factor Binding Proteins (Igfbp)mentioning

confidence: 97%

Biochemistry testing associated with pregnancy and the newborn period—A lot has changed since you were a baby!

Thorlacius¹,

Blakney

Krahn

et al. 2006

Clinical Biochemistry

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New rapid bed‐side test to predict preterm delivery: phosphorylated insulin‐like growth factor binding protein‐1 in cervical secretions

Abstract: The presence of cervical phIGFBP-1 is predictive of preterm delivery < 37 weeks of gestation. Our study shows that cervical detection of phIGFBP-1 by immunochromotography is a rapid and easily applicable test that highly anticipates preterm delivery in patients at risk.

Cited by 64 publications

References 15 publications

Cervical phosphorylated insulin-like growth factor binding protein-1 test for the prediction of preterm birth: a systematic review and metaanalysis

Cervical phosphorylated insulin-like growth factor binding protein-1 test for the prediction of preterm birth: a systematic review and metaanalysis

Can Preterm Labour Be Predicted in Low Risk Pregnancies? Role of Clinical, Sonographic, and Biochemical Markers

Biochemistry testing associated with pregnancy and the newborn period—A lot has changed since you were a baby!

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