New rapid bed-side test to predict preterm delivery: phosphorylated insulin-like growth factor binding protein-1 in cervical secretions

Lembet, Arda; Eroğlu, Derya; Ergin, Tolga; Kuşçu, Esra; Zeyneloğlu, Hulusi Bülent; Batıoğlu, Sertaç; Haberal, Alı

doi:10.1080/j.1600-0412.2002.810804.x

Cited by 19 publications

(36 citation statements)

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“…fFN false results can obtained in cases of amniotic fluid contamination, vaginal bleeding, and unprotected sexual intercourse [4]. IGFBP-1 belongs to the insulin-like binding proteins super-family, released into CVF during the process of the chorio-decidual disruption, and its detection in the CVF associated with increased risk of PTL [12] [13]. Clinical diagnostic trials indicate that fFN and phIGFBP1 are good negative predictors of PTL (92% specificity) with limited sensitivity, and PPVs in asymptomatic women [14].…”

Section: Introductionmentioning

confidence: 99%

Diagnostic Accuracy of PremaQuick versus Actim Partus in Prediction of Preterm Labor in Symptomatic Women within 14 Days

Abu-Faza¹,

Abdelazim²,

Svetlana³

et al. 2018

OJOG

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Background: Preterm labor (PTL) remains a major source of neonatal morbidity, and mortality. Currently the trans-vaginal cervical length (TVCL), and/or cervico-vaginal fetal fibronectin (fFN) are the common diagnostic tools used for prediction of PTL. Consequently, many women and their fetuses are exposed unnecessarily tocolysis and hospital admission. Objectives: This study was designed to compare the diagnostic accuracy of PremaQuick versus Actim Partus in prediction of PTL in symptomatic women within 14 days. Patients and Methods: Two-hundred and twenty women (220) were included in this comparative prospective study and classified into two groups: 110 women with threatened preterm labor (TPTL) in the study group, and 110 controls (no TPTL). Women included in the study were subjected to: through history, collection of the cervico-vaginal fluid (CVF) samples for assessment by PremaQuick and Actim Partus tests, followed by trans-vaginal cervical length (TVCL) assessment. Studied women managed according to the hospitals protocol, with follow-up weekly in the obstetrics outpatients' clinic after discharge from the hospital until delivery. The main outcome measures the diagnostic accuracy of PremaQuick versus Actim Partus in prediction of PTL in symptomatic women within 14 days of admission. Results: PremaQuick test was significantly more specific with higher positive predictive value (PPV) in prediction of PTL in symptomatic women within 14 days (95.5% and 89.6%; respectively) compared to CL < 25 mm (56.3% and 54.6%; 742 Open Journal of Obstetrics and Gynecology respectively), (P = 0.02 and 0.03; respectively). In addition, PremaQuick test was significantly more sensitive with higher positive predictive value (PPV) in prediction of PTL in symptomatic women within 14 days (39.8% and 89.6%; respectively) compared to Actim Partus (13.9% and 55.5%; respectively), (P = 0.001 and 0.01; respectively). The Odds ratio and the relative risk for prediction of PTL in symptomatic women within 14 days were significantly high for PremaQuick compared to the CL < 25 mm, and Actim Partus. Conclusion: PremaQuick test seems to be the best complementary test to the CL < 25 in prediction of PTL in symptomatic women within 14 days. PremaQuick test compensates the low specificity and low PPV of the CL < 25 mm in prediction of PTL.

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Section: Introductionmentioning

confidence: 99%

Diagnostic Accuracy of PremaQuick versus Actim Partus in Prediction of Preterm Labor in Symptomatic Women within 14 Days

Abu-Faza¹,

Abdelazim²,

Svetlana³

et al. 2018

OJOG

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“…This was followed by many studies showing high sensitivity (70-80%) and negative predictive value (79-90%) of the test [8][9][10][11].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Phosphorylated Insulin like Growth Factor Binding Protein-1 and Sonographically Measured Cervical Length for Prediction of Preterm Birth in Threatened Preterm Labor: A Clinical Approach

Tripathi¹,

Tyagi²,

Yadav³

et al. 2017

IPCB

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Background and Objectives: Measurement of cervical length using Transvaginal Sonography (TVS) is commonly used to identify those patients of threatened preterm labor who are likely to deliver. Biochemical markers in cervical secretions namely fetal fibronectin and Phosphorylated Insulin like Growth Factor Binding Protien-1 (phIGFBP-1) have also been used to improve predictability. This study evaluated bedside kit test for phIGFBP-1 and cervical length measurement by TVS, individually and in combination, for prediction of preterm birth in patients with threatened preterm labor.

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“…phIGFBP-1 test: positive (X10 mg l À1 ) versus negative (<10 mg l À1 ) test, as recommended by Lembet et al 11 and the manufacturer of the test (Medix Biochemica). fFN test: positive (X50 ng ml À1 ) versus negative (<50 ng ml À1 ), as defined by the manufacturer (Adeza Biomedical Corporation, Sunnyvale, CA, USA).…”

Section: Main Data Itemsmentioning

confidence: 99%

“…Nonetheless, available research suggested that a negative phIGFBP-1 test would rule out imminent delivery in B90 to 95% of patients. [7][8][9][10][11] The negative predictive value (NPV) of phIGFBP-1 was therefore felt to be comparable to fFN, although there was little evidence directly comparing the two tests in the same population. 12 Our prospective cohort study set out to examine the sensitivity, specificity, positive predictive value (PPV) and NPV of phIGFBP-1 test in predicting preterm delivery in women with symptoms of preterm labor.…”

Section: Introductionmentioning

confidence: 99%

Diagnostic accuracy of rapid phIGFBP-I assay for predicting preterm labor in symptomatic patients

et al. 2011

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Objective: To estimate sensitivity, specificity, positive and negative predictive values (PPV, NPV) of insulin-like growth factor binding protein-1 (phIGFBP-1) test in predicting preterm delivery in women with symptoms of preterm labor. Secondary objectives were to compare test characteristics of the phIGFBP-1 and fetal fibronectin (fFN) tests.Study Design: Labor and delivery units in two Calgary hospitals. Subjects were 349 women with suspected labor between 24 and 35 weeks gestational age (GA). Women had cervical phIGFBP-1 test þ /À and fFN testing. Sensitivity, specificity, PPV and NPV were estimated. Primary outcome was birth <37 weeks GA.Result: Sensitivity of phIGFBP-1 test for delivery <37 weeks was 0.39; specificity, 0.76; PPV, 0.24; NPV, 0.86. NPV of phIGFBP-1 did not differ greatly from that of fFN testing (0.88).Conclusion: NPV did not differ between phIGFBP-1 and fFN for delivery <37 weeks. Neither test improves on pretest probability of delivery <37 weeks, so clinicians must decide whether the use of either test is justified.

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New rapid bed-side test to predict preterm delivery: phosphorylated insulin-like growth factor binding protein-1 in cervical secretions

Cited by 19 publications

References 0 publications

Diagnostic Accuracy of PremaQuick versus Actim Partus in Prediction of Preterm Labor in Symptomatic Women within 14 Days

Diagnostic Accuracy of PremaQuick versus Actim Partus in Prediction of Preterm Labor in Symptomatic Women within 14 Days

Evaluation of Phosphorylated Insulin like Growth Factor Binding Protein-1 and Sonographically Measured Cervical Length for Prediction of Preterm Birth in Threatened Preterm Labor: A Clinical Approach

Diagnostic accuracy of rapid phIGFBP-I assay for predicting preterm labor in symptomatic patients

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