New Pyran‐2‐ones from Alkalophilic Actinomycete, <i>Nocardiopsis alkaliphila</i> sp. Nov. YIM‐80379

Wang, Zhiying; Fu, Peng; Li, Peipei; Wang, Pei; Hou, Jiabo; Li, Wenjun; Zhu, Weiming

doi:10.1002/cbdv.201200086

Cited by 22 publications

(13 citation statements)

References 26 publications

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“…Additionally, the IR displays the characteristic absorptions of a secondary amide group at 3441, 1650, and 1540 cm À l . 1 H, 1 H-COSY Correlations HÀC(1)/HÀC(2)/HÀC(3) and HÀC(5)/HÀC(6)/HÀC (7), and HMBCs from HÀC (13) to C(3), from HÀC (14) to C(5), from HÀC(23) to C(7), from HÀC (15) to C(1), C (9), and C(10), from HÀC(5) to C(4) and C (6), from HÀC(6) to C (8) and C(10), from HÀC(1) to C(3) and C (10), and from HÀC (11) to C(8) and C(9) further corroborated the alleged drimane-type sesquiterpene lactone moiety (Fig. These NMR data suggested the presence of a drimane-type sesquiterpene skeleton with an Nacetylvaline side chain similar to purpuride (4) [10].…”

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confidence: 99%

Purpurides B and C, Two New Sesquiterpene Esters from the Aciduric Fungus Penicillium purpurogenum JS03‐21

Wang

et al. 2013

Chemistry & Biodiversity

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Purpurides B and C (1 and 2, resp.), two new sesquiterpene alcohol esters generated from a drimane-type sesquiterpenoid lactone and an amino acid, together with two known analogs, berkedrimane B (3) and purpuride (4), were isolated from the aciduric fungus Penicillium purpurogenum JS03-21. Their structures were elucidated by spectroscopic analysis, X-ray single-crystal diffraction, and application of Marfey's method. Compounds 1-4 showed modest antifungal activities against Candida albicans with MIC values in the range of 1.2-3.3 μM. Compounds 1 and 2 showed moderate antimicrobial activities against Enterobacter aerogenes and Pseudomonas aeruginosa with MIC values in the range of 1.2-2.6 μM.

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confidence: 99%

Purpurides B and C, Two New Sesquiterpene Esters from the Aciduric Fungus Penicillium purpurogenum JS03‐21

Wang

et al. 2013

Chemistry & Biodiversity

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“…9 : compound 1–6). They affiliate to four groups: diketopiperazines (DKPs) group 24 (compound 1–3), phenoxazine derivatives 25 (compound 4), alpha-pyrone group 26 (compound 5), and pyranonaphthoquinone (PNQ) group 27 (compound 6). Concretely speaking, three diketopiperazines (DKPs) compounds (1–3) produced by a deep-sea-derived Nocardiopsis alba SCSIO 03039 formerly reported did not showed any antibacterial activities against four indicator strains Escherichia coli ATCC 25922, Staphylococcus aureus ATCC 29213, Bacillus subtilis SCSIO BS01 and Bacillus thuringiensis SCSIO BT01 24 .…”

Section: Resultsmentioning

confidence: 99%

“…236 against M. smegmatis was tested, yet it didn’t show any antibacterial activity 28 . Nocardiopyrones A (5) produced by Nocardiopsis alkaliphila , an alkalophilic actinomycete showed weak antibacterial activities against Pseudomonas aeruginosa , Enterobacter aerogenes and Escherichia coli with MIC values of 20, 40 and 40 μM and showed no activity against both Staphylococcus aureus and Candida albicans with more than 100 μM of MIC values 26 . Griseusins G (6) produced by Nocardiopsis sp.…”

Section: Resultsmentioning

confidence: 99%

Genome-guided Investigation of Antibiotic Substances produced by Allosalinactinospora lopnorensis CA15-2T from Lop Nor region, China

Huang

Leung

Guo

et al. 2016

Sci Rep

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Microbial secondary metabolites are valuable resources for novel drug discovery. In particular, actinomycetes expressed a range of antibiotics against a spectrum of bacteria. In genus level, strain Allosalinactinospora lopnorensis CA15-2T is the first new actinomycete isolated from the Lop Nor region, China. Antimicrobial assays revealed that the strain could inhibit the growth of certain types of bacteria, including Acinetobacter baumannii and Staphylococcus aureus, highlighting its clinical significance. Here we report the 5,894,259 base pairs genome of the strain, containing 5,662 predicted genes, and 832 of them cannot be detected by sequence similarity-based methods, suggesting the new species may carry a novel gene pool. Furthermore, our genome-mining investigation reveals that A. lopnorensis CA15-2T contains 17 gene clusters coding for known or novel secondary metabolites. Meanwhile, at least six secondary metabolites were disclosed from ethyl acetate (EA) extract of the fermentation broth of the strain by high-resolution UPLC-MS. Compared with reported clusters of other species, many new genes were found in clusters, and the physical chromosomal location and order of genes in the clusters are distinct. This study presents evidence in support of A. lopnorensis CA15-2T as a potent natural products source for drug discovery.

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“…b) along with other identified compounds, (three known pyridinols and 1‐acetyl‐β‐carboline) were obtained from Nocardiopsis alkaliphila YIM‐80379 that was isolated from a desert soil sample (Wang et al . ). Nocardiopyrone A was active against Pseudomonas aeruginosa , Enterobacter aerogenes and Escherichia coli .…”

Section: Polyketide Structure‐based Antibioticsmentioning

confidence: 97%

Nocardiopsisspecies: a potential source of bioactive compounds

et al. 2015

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Summary Members of the genus Nocardiopsis are an ecologically versatile and biotechnologically important group of Actinomycetes. Most of the isolates are halotolerant or halophilic and they prevail in soils, marine environments or hypersaline locations. To aid their survival under these conditions, they mainly produce extremozymes, compatible solutes, surfactants and bioactive compounds. The current review details the bioactive compounds obtained for this genus. Important antimicrobial agents obtained from this genus include polyketides, phenzines, quinoline alkaloids, terphenyls, proteins, thiopeptides and amines. Polyketides and peptides displaying potent anticancer activities are also significant. Tumour promoting agents, P‐glycoprotein (P‐gp) inhibitors, immunomodulators and protein kinase inhibitors are other relevant products obtained from Nocardiopsis species. Structurally, polyketides (synthesized by polyketide synthases) and peptides (made by nonribosomal peptide synthetases or cyclodipeptide synthases) are important compounds. Considered here are also toxins, anti photoaging and adipogenic agents produced by this genus. The gene clusters mediating the synthesis of bioactive compounds have been described. Commercially available products (Apoptolidins and K‐252a) derived from this genus have also been described. This review highlights the significance of a single genus in producing an assortment of compounds with varied biological activities. On account of these features, the members of this genus have established a place for themselves and are of considerable value in producing compounds with profound bio‐medical applications.

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New Pyran‐2‐ones from Alkalophilic Actinomycete, Nocardiopsis alkaliphila sp. Nov. YIM‐80379

Cited by 22 publications

References 26 publications

Purpurides B and C, Two New Sesquiterpene Esters from the Aciduric Fungus Penicillium purpurogenum JS03‐21

Purpurides B and C, Two New Sesquiterpene Esters from the Aciduric Fungus Penicillium purpurogenum JS03‐21

Genome-guided Investigation of Antibiotic Substances produced by Allosalinactinospora lopnorensis CA15-2T from Lop Nor region, China

Nocardiopsisspecies: a potential source of bioactive compounds

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