Nocardiopsisspecies: a potential source of bioactive compounds

Abstract

Summary Members of the genus Nocardiopsis are an ecologically versatile and biotechnologically important group of Actinomycetes. Most of the isolates are halotolerant or halophilic and they prevail in soils, marine environments or hypersaline locations. To aid their survival under these conditions, they mainly produce extremozymes, compatible solutes, surfactants and bioactive compounds. The current review details the bioactive compounds obtained for this genus. Important antimicrobial agents obtained from this genus include polyketides, phenzines, quinoline alkaloids, terphenyls, proteins, thiopeptides and amines. Polyketides and peptides displaying potent anticancer activities are also significant. Tumour promoting agents, P‐glycoprotein (P‐gp) inhibitors, immunomodulators and protein kinase inhibitors are other relevant products obtained from Nocardiopsis species. Structurally, polyketides (synthesized by polyketide synthases) and peptides (made by nonribosomal peptide synthetases or cyclodipeptide synthases) are important compounds. Considered here are also toxins, anti photoaging and adipogenic agents produced by this genus. The gene clusters mediating the synthesis of bioactive compounds have been described. Commercially available products (Apoptolidins and K‐252a) derived from this genus have also been described. This review highlights the significance of a single genus in producing an assortment of compounds with varied biological activities. On account of these features, the members of this genus have established a place for themselves and are of considerable value in producing compounds with profound bio‐medical applications.

Sequencing rare marine actinomycete genomes reveals high density of unique natural product biosynthetic gene clusters

“…S5), the added variety of clusters from the RMA genomes may be due to their marine nature. A recent review details the current natural products from Nocardiopsis species and the unique potential of marine Nocardiopsis strains (Bennur et al, 2016). This genomic analysis corroborates their assertion that marine Nocardiopsis strains are promising in the pursuit of novel bioactive small molecules.…”

Antibiotic Resistance in Urinary Isolates of Escherichia coli

“…The majority of strains of E. coli were identified as resistant to the antibiotics such as ampicillin, amoxicillin / clavulanic acid, norfloxacin, cefuroxime, ceftriaxone, and trimethoprim/sulfamethoxazole (13). The emergence of antibiotic resistance is a major threat to public health, which is driven by excessive use of antibiotics.…”

Bioactivity and genetic screening of marine actinobacteria associated with red algae Gelidiella acerosa

“…Nocardiopsis has been isolated from marine sediments, marine invertebrates association, and hyper saline environments (He et al 2015). Nocardiopsis produce bioactive compounds with various activities such as antibiotics, anticancer, and immunomodulator agent (Bennur et al 2016). Macrocyclic thiopeptide antibiotics TP-1161 produced by marine Nocardiopsis sp.…”