Antibiotic Resistance in Urinary Isolates of Escherichia coli

Abstract

Objectives:The aim of this study was to examine the presence of antimicrobial resistance / susceptibility strains of Escherichia coli in inpatients and outpatients.Materials and methods:It is a retrospective study carried out at the Department of Microbiology, Parasitology and Virology Faculty of Medicine, University of Sarajevo. In cooperation with the Microbiological laboratory of the Cantonal Hospital Zenica and the Microbiological laboratory of the General Hospital Tesanj, 3863 urine samples were processed in the period from March 1st to March 31st 2016.Results:Our study showed that E. coli had the highest antimicrobial resistance to trimethoprim / sulfamethoxazole (38.61%), followed by amoxicillin / clavulanic acid (19.62%), ciprofloxacin (9.49%), gentamicin (8.86%), cephalexin (8.23%), nitrofurantoin (8.23%), cefuroxime (7.52%), ceftazidime (6.33%), cefuroxime (89.87%), amikacin (4.43%).Conclusions:The isolated strains of E. coli showed the highest resistance to trimethoprim / sulfamethoxazole and amoxicillin / clavulanic acid. The isolated strains of E. coli showed the greatest susceptibility to amikacin and ceftazidime. Gender distribution of positive E. coli isolates showed statistically significant differences in favor of females.

Pattern of Antimicrobial Resistance to <i>Escherichia Coli</i> Among the Urinary Tract Infection Patients in Bangladesh

“…Some studies favor and some goes against the result of 85 our present study. [18,26,27] But less increasing resistance (from 0.7% to 0.9%) and higher susceptibility (>80%) in US support our report. [4,25] c. Ciprofloxacin: The quinolone derivative, Ciprofloxacin is used empirically not only in UTIs but also in various forms infections due to its safety profile and cheap in price.…”

“…[15] It is well postulated that UTI is more common among the woman due to the closer alignment of urethra to the anus and shorter urethra which we have found in our present study at a ratio of 8:1.5. [16][17][18][19] Common risk factors causing UTIs are sexually active premenopausal women, use of spermicides for contraceptive, frequent change of sexual partners, age of the first UTI, maternal history of UTI, wearing tight undergarments, deferred voiding habit, pregnancy, DM and immunosuppression due to any cause. [20][21][22] So, reproductive age plays a vital role as a risk factor for developing UTI in both sex.…”

Prevalence of Multidrug Resistance and Extended-Spectrum β-Lactamase Carriage of Clinical Uropathogenic Escherichia coli Isolates in Riyadh, Saudi Arabia

“…This finding is in agreement with many previous reports [ 30 , 40 – 42 ] showing that ESBL-producing E. coli isolates were more resistant to trimethoprim-sulphamethoxazole, ciprofloxacin, and third-generation cephalosporins compared to non-ESBL-producing E. coli , although this resistance did not affect imipenem. This increased resistance levels of ESBL-producing E. coli isolates to some front-line antibiotics such as cephalosporins, trimethoprim-sulphamethoxazole, and ciprofloxacin, could be ascribed to the inappropriate and excessive use of these agents in the empirical treatment of UTIs [ 43 ]. It has been shown that these antibiotics are commonly used for the treatment of UTIs worldwide [ 44 ], and the currently reported increase in resistance trends among uropathogens, primarily E. coli , has not only led to high rates of morbidity and mortality [ 45 ], but it has also complicated the management of UTIs [ 46 ].…”

The Most Frequent Isolates from Outpatients with Urinary Tract Infection

“…This can be achieved by constant supervision and knowledge of the most common bacterial species as the etiologic agents of urinary tract infections, as well as their resistance profile (19). …”

“…It is essential to maintain the safety and feasibility of empirical therapy, as a strategy for managing urinary tract infections in female. This can be achieved by constant supervision and knowledge of the most common bacterial species as the etiologic agents of urinary tract infections, as well as their resistance profile ( 19 ).…”