New prenylated flavonoid and neuroprotective compounds from <i>Tephrosia purpurea</i> subsp. <i>dunensis</i>

Sallam, Amal; Mira, Amira; Sabry, Mohamed; Abdel-Halim, Osama B.; Gedara, Sahar R.; Galala, Amal A.

doi:10.1080/14786419.2020.1815739

Cited by 4 publications

(5 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, compared with the control group, pilocarpine injection significantly increased brain MDA and NO levels; however, (-) pseudosemiglabrin pretreatment resulted in a dose-dependent reduction in raised MDA and NO levels compared with the PIL group. These findings support prior research on the antioxidant potentiality of (-) pseudosemiglabrin and Tephrosia species, in which (-) pseudosemiglabrin is the predominant biologically active component [ 22 , 23 , 25 , 26 , 27 ]. Additionally, these effects are comparable to those of diazepam, a medicine known to decrease oxidative stress; nevertheless, (-) pseudosemiglabrin considerably lowered the elevated NO level, but diazepam did not [ 42 , 43 ].…”

Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

“…The major potential bioactive flavanone identified in Tephrosia species’ aerial portions is (-) pseudosemiglabrin [ 20 , 21 , 22 ]. It was recently discovered to have pivotal potentialities, including anti-inflammatory, neuroprotective, analgesic, antioxidant, antiplatelet, antidyslipidemic, diuretic, anti-cancer, and anti-angiogenic properties [ 20 , 21 , 22 , 23 , 24 , 25 ]. Additionally, Tephrosia purpurea extract, whose primary bioactive component is (-) pseudosemiglabrin, demonstrated potent anticonvulsant efficacy via antioxidant, anti-inflammatory, and GABAergic transmission modulation [ 26 , 27 ].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Ameliorative Potential of (-) Pseudosemiglabrin in Mice with Pilocarpine-Induced Epilepsy: Antioxidant, Anti-Inflammatory, Anti-Apoptotic, and Neurotransmission Modulation

Balaha

Alamer

Abdel-Kader

et al. 2023

IJMS

View full text Add to dashboard Cite

One prevalent neurological disorder is epilepsy. Modulating GABAergic/glutamatergic neurotransmission, Nrf2/HO-1, PI3K/Akt, and TLR-4/NF-B pathways might be a therapeutic strategy for epilepsy. Eight-week-old BALB/c mice were administered 12.5, 25, or 50 mg/kg (-) pseudosemiglabrin orally one hour before inducing epilepsy with an i.p. injection of 360 mg/kg pilocarpine. (-) Pseudosemiglabrin dose-dependently alleviated pilocarpine-induced epilepsy, as revealed by the complete repression of pilocarpine-induced convulsions and 100% survival rate in mice. Furthermore, (-) pseudosemiglabrin significantly enhanced mice’s locomotor activities, brain GABA, SLC1A2, GABARα1 levels, glutamate decarboxylase activity, and SLC1A2 and GABARα1mRNA expression while decreasing brain glutamate, SLC6A1, GRIN1 levels, GABA transaminase activity, and SLC6A1 and GRIN1 mRNA expression. These potentials can be due to the suppression of the TLR-4/NF-κB and the enhancement of the Nrf2/HO-1 and PI3K/Akt pathways, as demonstrated by the reduction in TLR-4, NF-κB, IL-1β, TNF-α mRNA expression, MDA, NO, caspase-3, Bax levels, and Bax/Bcl-2 ratio, and the enhancement of Nrf2, HO-1, PI3K, Akt mRNA expression, GSH, Bcl-2 levels, and SOD activity. Additionally, (-) pseudosemiglabrin abrogated the pilocarpine-induced histopathological changes. Interestingly, the (-) pseudosemiglabrin intervention showed a comparable effect to the standard medication, diazepam. Therefore, (-) pseudosemiglabrin can be a promising medication for the management of epilepsy.

show abstract

Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Ameliorative Potential of (-) Pseudosemiglabrin in Mice with Pilocarpine-Induced Epilepsy: Antioxidant, Anti-Inflammatory, Anti-Apoptotic, and Neurotransmission Modulation

Balaha

Alamer

Abdel-Kader

et al. 2023

IJMS

View full text Add to dashboard Cite

show abstract

“…The presented results were in agreement that cytotoxicity of SO was mediated by oxidative stress and apoptosis, necrosis, and necroptosis mechanisms, and at the same time, quercetin delivered the neuroprotection [114]. Quercetin 3, 7-O-α-L-dirhamnoside, a quercetin derivative, was found actively in providing a protective effect against induced neurotoxicity [115]. The brain targeting of quercetin-loaded exosomes enhanced its bioavailability in Alzheimer's disease (AD) and further relieved the symptoms of AD via inhibition of biochemical pathways such as cyclin-dependent kinase 5 (CDK5)-mediated phosphorylation of phosphoprotein Tau and decrease of the formation of insoluble neurofibrillary tangles (NFTs) [116].…”

Section: Quercetin As a Neuroprotective Agentsupporting

confidence: 84%

Quercetin: A Bioactive Compound Imparting Cardiovascular and Neuroprotective Benefits: Scope for Exploring Fresh Produce, Their Wastes, and By-Products

Bhat

2021

Biology

View full text Add to dashboard Cite

Quercetin, a bioactive secondary metabolite, holds incredible importance in terms of bioactivities, which has been proved by in vivo and in vitro studies. The treatment of cardiovascular and neurological diseases by quercetin has been extensively investigated over the past decade. Quercetin is present naturally in appreciable amounts in fresh produce (fruits and vegetables). However, today, corresponding to the growing population and global demand for fresh fruits and vegetables, a paradigm shift and focus is laid towards exploring industrial food wastes and/or byproducts as a new resource to obtain bioactive compounds such as quercetin. Based on the available research reports over the last decade, quercetin has been suggested as a reliable therapeutic candidate for either treating or alleviating health issues, mainly those of cardiovascular and neurological diseases. In the present review, we have summarized some of the critical findings and hypotheses of quercetin from the available databases foreseeing its future use as a potential therapeutic agent to treat cardiovascular and neurological diseases. It is anticipated that this review will be a potential reference material for future research activities to be undertaken on quercetin obtained from fresh produce as well as their respective processing wastes/byproducts that rely on the circular concept.

show abstract

“…Phenolic compounds from natural sources have shown anticholinesterase activity in several studies [ 34 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 ]. Phenolic compounds whose anticholinesterase activities have been reported are given in the Supplementary Material ( Table S2 ).…”

Section: Discussionmentioning

confidence: 99%

Non-Alkaloid Cholinesterase Inhibitory Compounds from Natural Sources

et al. 2021

View full text Add to dashboard Cite

Alzheimer’s disease (AD) is a severe neurodegenerative disorder of different brain regions accompanied by distresses and affecting more than 25 million people in the world. This progressive brain deterioration affects the central nervous system and has negative impacts on a patient’s daily activities such as memory impairment. The most important challenge concerning AD is the development of new drugs for long-term treatment or prevention, with lesser side effects and greater efficiency as cholinesterases inhibitors and the ability to remove amyloid-beta(Aβ) deposits and other related AD neuropathologies. Natural sources provide promising alternatives to synthetic cholinesterase inhibitors and many have been reported for alkaloids while neglecting other classes with potential cholinesterase inhibition. This review summarizes information about the therapeutic potential of small natural molecules from medicinal herbs, belonging to terpenoids, coumarins, and phenolic compounds, and others, which have gained special attention due to their specific modes of action and their advantages of low toxicity and high efficiency in the treatment of AD. Some show superior drug-like features in comparison to synthetic cholinesterase inhibitors. We expect that the listed phytoconstituents in this review will serve as promising tools and chemical scaffolds for the discovery of new potent therapeutic leads for the amelioration and treatment of Alzheimer’s disease.

show abstract

New prenylated flavonoid and neuroprotective compounds from Tephrosia purpurea subsp. dunensis

Cited by 4 publications

References 17 publications

Ameliorative Potential of (-) Pseudosemiglabrin in Mice with Pilocarpine-Induced Epilepsy: Antioxidant, Anti-Inflammatory, Anti-Apoptotic, and Neurotransmission Modulation

Ameliorative Potential of (-) Pseudosemiglabrin in Mice with Pilocarpine-Induced Epilepsy: Antioxidant, Anti-Inflammatory, Anti-Apoptotic, and Neurotransmission Modulation

Quercetin: A Bioactive Compound Imparting Cardiovascular and Neuroprotective Benefits: Scope for Exploring Fresh Produce, Their Wastes, and By-Products

Non-Alkaloid Cholinesterase Inhibitory Compounds from Natural Sources

Contact Info

Product

Resources

About