New polymer–halloysite hybrid materials—potential controlled drug release system

Ghebaur, Adi; Gârea, Sorina Alexandra; Iovu, Horia

doi:10.1016/j.ijpharm.2012.07.014

Cited by 67 publications

(36 citation statements)

References 18 publications

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“…Some sources claim that molecules can penetrate also into the interlamellar space . The majority of the groups using halloysite as carrier material for active molecules assume that these latter are located within the tubes and released from there to achieve prolonged effect [2][3][4][5][6][7][8][9][10][11][12][13][14]. Unfortunately, usually not much proof is supplied for this assumption and further study and model calculations must be carried out to define the location and distribution of quercetin molecules on the surface of the halloysite unambiguously.…”

Section: Discussion Consequencesmentioning

confidence: 99%

“…Halloysite is a naturally occurring mineral, which is available both in platelet like and tubular form. Numerous attempts have been made to use halloysite nanotubes as carriers for all kinds of bioactive molecules including drugs [2][3][4][5][6][7][8][9][10][11][12][13][14]. However, besides medical applications, halloysite nanotubes are used as supports in other areas as well.…”

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confidence: 99%

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Competitive interactions and controlled release of a natural antioxidant from halloysite nanotubes

Hári

Gyürki

Sárközi

et al. 2016

Journal of Colloid and Interface Science

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Halloysite nanotubes used as potential carrier material for a controlled release stabilizer in polyethylene were thoroughly characterized with several techniques including the measurement of specific surface area, pore volume and surface energy. The high surface energy of the halloysite results in the strong bonding of the additive to the surface.Dissolution experiments carried out with eight different solvents for the determination of the effect of solvent characteristics on the amount of irreversibly bonded quercetin proved that adsorption and dissolution depend on competitive interactions prevailing in the system. Solvents with low polarity dissolve only surplus quercetin adsorbed in multilayers.Polyethylene is a very apolar polymer forming weak interactions with every substance; quercetin dissolves into it only above a critical concentration. Stabilization experiments confirmed that strong adhesion prevents dissolution and results in limited stabilization efficiency. At larger adsorbed amounts better stability and extended effect were measured indicating dissolution and controlled release.

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Section: Discussion Consequencesmentioning

confidence: 99%

mentioning

confidence: 99%

Competitive interactions and controlled release of a natural antioxidant from halloysite nanotubes

Hári

Gyürki

Sárközi

et al. 2016

Journal of Colloid and Interface Science

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“…The applications of HNTs as drug release vehicles were broadly reported in publications [65][66][67] and the drug release rate can be further delayed by coating polymers onto the drug-loaded HNTs 11,68 . HNTs-polymer nanocomposites can be used as drug containers 69,70 .…”

Section: Hnts As a Potential Drug Delivery Vehicle Bone Implants Andmentioning

confidence: 99%

“…HNTs-polymer nanocomposites can be used as drug containers 69,70 . Coating of PVA on the HNTs can slow down diphenhydramine hydrochloride release 11 . Furthermore, the chitosanand PEI-coated HNTs exhibit show a radically reduced release comparatively to the uncoated HNTs.…”

Section: Hnts As a Potential Drug Delivery Vehicle Bone Implants Andmentioning

confidence: 99%

Escalating Applications of Halloysite Nanotubes

Saif

Asif

2015

J. Chil. Chem. Soc.

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In nanotechnology different nano materials are used like carbon nanotubes, nanofluids, nanoparticles, nanoemulsions, nanocapsules, etc. Due to their toxic effects the results of these nano materials are not considered safe for humans and for the environment as well. Halloysite nanotubules (HNTs) having low cost are naturally occurring environmental friendly nanotubules. These are distinctive and handy materials formed by face weathering of aluminosilicate minerals having definite ratio of aluminum, silicon, hydrogen, and oxygen. HNTs have high mechanical strength and modulus. Due to these properties it is ideal for various applications; remediation of ecological contaminants, these are acting as a career for the delivery of drugs and various macro molecules, storage of H 2 gas, for catalytic conversions and for the processing of hydrocarbons. These are also used in anticancer therapy, sustained delivery for certain agents, as a template or nanoreactor for biocatalyst, in personal care, cosmetics and as environment caring. They are also used in the fabrication of high quality white-ware ceramics, nanotemplates and nano scale reaction bottles. Due to easy dispersability in polymer matrix, abundant availability and biocompatibility, HNTs are also used in different epoxy (EP) composites. In this review, we have tried to recap the different aspects of halloysites nanotubes for their use in different research fields.

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“…Halloysite is a natural material with demonstrated low toxicity both in vitro [10] and in vivo [11]. Incorporation of 5-aminosalicylic acid [12], diphenhydramine hydrochloride [13], diltiazem HCl, propranolol HCl [14], tetracycline hydrochloride [15], dexamethasone, furosemide and nifedipine [16] and cardanol [17] into halloysite was investigated and encouraging results were obtained. Recently, pH 3 and thermo-responsive [18] nanocarriers for curcumin were successfully prepared though the modification of halloysite surfaces.…”

Section: Introductionmentioning

confidence: 99%

Direct chemical grafted curcumin on halloysite nanotubes as dual-responsive prodrug for pharmacological applications

Massaro

Amorati

Cavallaro

et al. 2016

Colloids and Surfaces B: Biointerfaces

145

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New polymer–halloysite hybrid materials—potential controlled drug release system

Cited by 67 publications

References 18 publications

Competitive interactions and controlled release of a natural antioxidant from halloysite nanotubes

Competitive interactions and controlled release of a natural antioxidant from halloysite nanotubes

Escalating Applications of Halloysite Nanotubes

Direct chemical grafted curcumin on halloysite nanotubes as dual-responsive prodrug for pharmacological applications

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