New polylactic acid/ cellulose acetate-based antimicrobial interactive single dose nanofibrous wound dressing mats

Gomaa, Salma F.; Madkour, Tarek M.; Moghannem, Saad A.; El‐Sherbiny, Ibrahim M.

doi:10.1016/j.ijbiomac.2017.07.145

Cited by 101 publications

(48 citation statements)

References 27 publications

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“…The presence of this ingredient accelerated the rate of wound closure and re-epithelialization and promoted cell proliferation. [43] In another study Aytac et al Produced thymol/Cyclodextrin inclusion complex encapsulated electrospun zein nanofibrous webs for food packaging application. It was reported that zein-THY/CD with the ratios of 2:1 was most effective in inhibiting the growth of bacteria and webs show potential application as an antibacterial food packaging material.…”

Section: Introductionmentioning

confidence: 99%

Electrospun PCL and PLA hybrid nanofibrous scaffolds containing Nigella sativa herbal extract for effective wound healing

Sharifi

Bahrami

Nejad

et al. 2020

J of Applied Polymer Sci

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Black seed (Nigella sativa [NS]) is used in traditional medicine as an antibacterial agent. In this study, novel hybrid scaffolds were manufactured from poly(ɛ‐caprolactone[PCL])/ Poly(lactic acid [PLA]) with NS extract by double‐nozzle electrospinning for wound healing application. Optimal conditions were found using response surface methodology including feed rate 0.8 ml/hr, voltage 20 kV and PLA 8% /PCL 10% concentrations. The effect of NS extract on the properties of the scaffold was evaluated by scanning electron microscopy, contact angle, and mechanical test. The PLA‐PCL/NS 20% beadles, and smooth nanofibrous web was obtained as the optimum scaffold with an average diameter of 638 ± 69 nm and the contact angle of 44°. In addition, the biological properties of the scaffolds such as antibacterial against Staphylococcus aureus (gram‐positive) and Escherichia coli (gram‐negative) bacteria, MTT assay, extract release, and cell growth (human mesenchymal stem cells) were examined. Incorporation of NS extract into the nanofibers caused to enhance the biological properties, cell viability and cell proliferation without toxicity.

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Section: Introductionmentioning

confidence: 99%

Electrospun PCL and PLA hybrid nanofibrous scaffolds containing Nigella sativa herbal extract for effective wound healing

Sharifi

Bahrami

Nejad

et al. 2020

J of Applied Polymer Sci

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“…Potential use of BC modified with carboxymethyl groups and loaded with chitosan particles with encapsulated curcumin as material for healing skin wounds was shown in a study by Rojewska et al [11]. Gelatin/BC scaffolds accelerated healing of skin wounds in mice [12]; BC composites with silk fibroin effectively healed model skin wounds in rats [13], and that was confirmed by measuring the levels of expression of wound healing markers. Singla et al [14] used hydrogels prepared from bamboo cellulose nanocrystals loaded with silver particles to heal skin wounds in streptozotocin induced diabetic mice.…”

Section: In Vivo Experimentsmentioning

confidence: 93%

“…Full-thickness skin wounds in rats healed effectively under a film of BC nanocrystals/chitosan incorporating silver and curcumin particles [10]. BC scaffolds with curcumin particles encapsulated in chitosan and in composition with gelatin and fibrin were used to manage skin wounds in mice and rats [11][12][13]. Singla et al [14] investigated hydrogels prepared from bamboo cellulose nanocrystals loaded with silver particles, which successfully healed skin wounds in diabetic mice.…”

Section: Introductionmentioning

confidence: 99%

Biotechnological wound dressings based on bacterial cellulose and degradable copolymer P(3HB/4HB)

Volova

Shumilova

Nikolaeva

et al. 2019

International Journal of Biological Macromolecules

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Hybrid wound dressings have been constructed using two biomaterials: bacterial cellulose (BC) and copolymer of 3-hydroxybutyric and 4-hydroxybutyric acids [P(3HB/4HB)]a biodegradable polymer of microbial origin. Some of the experimental membranes were loaded with drugs promoting wound healing and epidermal cells differentiated from multipotent adipose-derived mesenchymal stem cells. A study has been carried out to investigate the structure and physical/mechanical properties of the membranes. The in vitro study showed that the most effective scaffolds for growing fibroblasts were composite BC/P(3HB/4HB) films loaded with actovegin. Two types of the experimental biotechnological wound dressings-BC/P(3HB/4HB)/actovegin and BC/P(3HB/ 4HB)/fibroblastswere tested in vivo, on laboratory animals with model third-degree skin burns. Wound planimetry, histological examination, and biochemical and molecular methods of detecting factors of angiogenesis, inflammation, type I collagen, and keratin 10 and 14 were used to monitor wound healing. Experimental wound dressings promoted healing more effectively than VoskoPrana commercial wound dressing.

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“…Natural products can overcome some of the key issues with the widespread use of synthetic antimicrobial agents by reducing side effects and the occurrence of drug resistant pathogens [60]. Natural components including aloe, cellulose, natural plant extracts, and fish skin collagen have been studied as chronic and burn wound dressings [90][91][92][93][94][95][96].…”

Section: Alternative Antimicrobial Treatmentsmentioning

confidence: 99%

Antibiotic Delivery Strategies to Treat Skin Infections When Innate Antimicrobial Defense Fails

et al. 2020

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The epidermal skin barrier protects the body from a host of daily challenges, providing protection against mechanical insults and the absorption of chemicals and xenobiotics. In addition to the physical barrier, the epidermis also presents an innate defense against microbial overgrowth. This is achieved through the presence of a diverse collection of microorganisms on the skin (the “microbiota”) that maintain a delicate balance with the host and play a significant role in overall human health. When the skin is wounded, the local tissue with a compromised barrier can become colonized and ultimately infected if bacterial growth overcomes the host response. Wound infections present an immense burden in healthcare costs and decreased quality of life for patients, and treatment becomes increasingly important because of the negative impact that infection has on slowing the rate of wound healing. In this review, we discuss specific challenges of treating wound infections and the advances in drug delivery platforms and formulations that are under development to improve topical delivery of antimicrobial treatments.

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New polylactic acid/ cellulose acetate-based antimicrobial interactive single dose nanofibrous wound dressing mats

Cited by 101 publications

References 27 publications

Electrospun PCL and PLA hybrid nanofibrous scaffolds containing Nigella sativa herbal extract for effective wound healing

Electrospun PCL and PLA hybrid nanofibrous scaffolds containing Nigella sativa herbal extract for effective wound healing

Biotechnological wound dressings based on bacterial cellulose and degradable copolymer P(3HB/4HB)

Antibiotic Delivery Strategies to Treat Skin Infections When Innate Antimicrobial Defense Fails

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