New platinum (II) and palladium (II) complexes of coumarin-thiazole Schiff base with a fluorescent chemosensor properties: Synthesis, spectroscopic characterization, X-ray structure determination, in vitro anticancer activity on various human carcinoma cell lines and computational studies

Şahin, Ömer; Özdemir, Uğur; Seferoğlu, Nurgül; Genç, Zuhal Karagöz; Kaya, Kerem; Aydıner, Burcu; Tekin, Suat; Seferoğlu, Zeynel

doi:10.1016/j.jphotobiol.2017.11.030

Cited by 67 publications

(22 citation statements)

References 52 publications

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“…The antiproliferative activities of metal complexes were high which was determined by IC50 value. The results showed that Pd(II) complex as higher antitumor effects [34].…”

Section: Introductionmentioning

confidence: 95%

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Schiff Base Metal Complexes as Anticancer Agents

Sridevi

Antony

R³

2019

Asian J. Chem.

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Cutting-edge practices in bioinorganic chemistry are pivotal for enhancing the layout of compounds to lessen poisonous facet effect and recognize their mechanism of action. A powerful anticancer agent should own inherent, inhibitory property and also delivery, dosage and residence time in vivo. Organic function and conformation of mutated gene may be altered by way of binding of metal ions. Upswing of activities counting on the structural data, intending in enhancing and growing different forms of metal based compounds, continuous seek of extra metal based compounds have been synthesized via revamping the prevailing chemical shape via ligand substitution. The prevailing paper addresses the trendy development in the design of novel antitumor agents primarily based on transition metal complex via highlighting the near dating among their structural alternatives and cytotoxic ability.

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“…The antiproliferative activities of metal complexes were high which was determined by IC50 value. The results showed that Pd(II) complex as higher antitumor effects [34].…”

Section: Introductionmentioning

confidence: 95%

“…Schiff base metal complexes containing thiazole based coumarin compounds were synthesized and reported by Sahin et al [34] (Fig. 25).…”

Section: Introductionmentioning

confidence: 99%

Schiff Base Metal Complexes as Anticancer Agents

Sridevi

Antony

R³

2019

Asian J. Chem.

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“… Coordination of metal ions to azomethine nitrogens led to υ(M‐N) stretching vibrations at 490–498 cm ‐1. From IR data, it could be concluded that the free L act as neutral bidentate ligand.…”

Section: Characterization Of Metal Complexesmentioning

confidence: 99%

Theoretical studies of new Schiff base ligand derived from 1,3‐diaminopropane and 2‐acetyl ferrocene and studying some applications of its metal complexes

Sayed

Mahmoud

Omar

2019

Applied Organom Chemis

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A novel bidentate Schiff base ligand (L) and some d‐transition metal chelates (Cr (III), Mn (II), Fe (III), Co (II), Ni (II), Cu (II), Zn (II) and Cd (II)) were synthesized and characterized using various physicochemical and spectroscopic techniques like elemental analysis, IR, mass, UV–visible and thermal analysis. The spectroscopic data suggested that the parent Schiff base ligand coordinated to the metal ions through both imine nitrogen atoms. The molecular and electronic structure of the free ligand was optimized theoretically, and the quantum chemical parameters were calculated. The molecular structure can be used to investigate the coordination sites and the total charge density around each atom. The free ligand and its complexes were screened for their antimicrobial activities for various pathogenic bacteria and fungi. The anticancer activities of the free ligand, Cr (III), Mn (II) and Fe (III) complexes were screened against MCF‐7 cell line and found that Mn (II) complex has the lowest IC50 (15.90 μg/ml). Molecular docking was used to predict the binding between the free ligand with receptor of mutant human androgen (ARccr) derived from androgen‐independent prostate cancer (1GS4), crystal structure of yeast‐specific serine/threonine protein phosphatase (ppz1) of Candida Albicans (5JPE) and crystal structure of renal tumor suppressor protein, folliculin (3 V42) and to identify the binding mode and the crucial functional groups interacting with the three proteins.

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“…Aromatik yapıdaki karbon-hidrojen (νAr-H) arasındaki gerilme bandı 3059 cm -1 de düşük şiddetli olarak görülmüştür. Alifatik yapıdaki karbon-hidrojen (νC-H) arasındaki zayıf gerilme frekansları 2973 ve 2933 cm -1 de tespit edilmiştir (Gupta et al, 2013;Şahin et al, 2018).1719, 1681 ve 1655 cm -1 deki güçlü IR frekansları sırasıyla kumarinin yapısındaki ester, benzoil ve pirimidin grubuna ait karbonil (νC=O) gruplarıyla ilişkilendirilmiştir (Sen et al, 2017;Ozdemir et al, 2017;Nuñez-Dallos et al, 2017). Bunlara ilave olarak, molekül yapısında bulunan azometin (νN=C-H) ve aromatik karbon-karbon çift bağ (C=C) titreşim bantları sırasıyla 1615 ve 1593 cm -1 de kaydedilmiştir (Wang et al, 2012;Özdemir et al, 2015).…”

Section: Kemosensör C1'in Senteziunclassified

A New, Colorimetric and Fluorescent Chemosensor for The Selective Detection of Fe2+ in Aqueous Media

Özdemir¹

2018

AKU-J. Sci. Eng.

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Son zamanlarda, kolorimetrik ve floresan sensörler, sulu ortamdaki ağır ve geçiş metal iyonlarının duyarlı ve seçici olarak tayin çalışmalarında düşük maliyet, kolay kullanım, yüksek performans, karmaşık olmayışı, test kiti olarak hazırlanma gibi avantajlar sağladıkları için önemli derecede ilgi çekmiştir. Bu çalışmada, kumarin temelli yeni bir kemosensör sentezlenmiş ve elementel analiz, FT-IR, Tandem kütle, 1 H NMR ve 13 C NMR spektroskopileri kullanılarak karakterize edilmiştir. Daha sonra, sensör C1'in seçicilik ve duyarlılık özelliği, biyolojik ve çevresel açıdan öneme sahip bazı metal iyonlarına karşı DMSO-H2O (v/v, 2:1) ortamında araştırılmıştır. UV-vis absorpsiyon ve floresan deneylerinden elde edilen sonuçlar, kemosensör C1'in sadece demir (II) iyonlarına yönelik seçicilik ve duyarlılık gösterdiğini ortaya çıkarmıştır.

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New platinum (II) and palladium (II) complexes of coumarin-thiazole Schiff base with a fluorescent chemosensor properties: Synthesis, spectroscopic characterization, X-ray structure determination, in vitro anticancer activity on various human carcinoma cell lines and computational studies

Cited by 67 publications

References 52 publications

Schiff Base Metal Complexes as Anticancer Agents

Schiff Base Metal Complexes as Anticancer Agents

Theoretical studies of new Schiff base ligand derived from 1,3‐diaminopropane and 2‐acetyl ferrocene and studying some applications of its metal complexes

A New, Colorimetric and Fluorescent Chemosensor for The Selective Detection of Fe2+ in Aqueous Media

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