New Plastoquinones Isolated from the Brown Alga, Sargassum micracanthum.

Abstract

New Plastoquinones Isolated from the Brown Alga, Sargassum micracanthum. -Theplastoquinones (I)-(III), isolated from the brown alga Sargassum micracanthum, exhibit significant antioxidant activities such as an inhibitory effect on lipid peroxidation and a radical-scavenging effect on DPPH. Some of them show cytotoxic activity. -(MORI, J.; IWASHIMA*, M.; WAKASUGI, H.; SAITO, H.; MATSUNAGA, T.; OGASAWARA, M.; TAKAHASHI, S.; SUZUKI, H.; HAYASHI, T.; Chem. Pharm. Bull. 53 (2005) 9, 1159-1163; Fac. Pharm. Sci., Toyama Med. Pharm. Univ., Toyama 930, Japan; Eng.) -M. Bohle 08-202

Ameliorative effect of polyphenols from Padina boergesenii against ferric nitrilotriacetate induced renal oxidative damage: With inhibition of oxidative hemolysis and in vitro free radicals

“…(Mandal et al, ; Liao et al, ). Similar results observed in both the extracts, where M extract exhibited comparatively higher activity than DEE extract, the solvent extractions had a dramatic effect on the chemical species (Mori et al, ; Esmaeili and Khakpoor, ). The highest inhibition of DPPH radical was observed in M extract, which is based on the ability of hydrogen donor species in extract like phenolic metabolites (flavonoid and flavonols) react with DPPH radical (Chu et al, ; Formagio et al, ).…”

“…The presence of phenolic metabolites in P. boergesenii extracts (DEE & M) were attributed for radical scavenging properties. Vogel et al () and Mori et al () reported for the occurrence of active metabolites with upright radical scavenging activities in M extract. The DPPH, deoxyribose, and FRAP assays gave comparable results for the antioxidant activity measured in M extract.…”

Towards a better understanding of medicinal uses of the brown seaweed Sargassum in Traditional Chinese Medicine: A phytochemical and pharmacological review

“…The fucoidan can inhibit the initial stages of viral infection, attachment to and penetration into host cells (Sinha et al, 2010), and replication stages after virus penetration (Preeprame et al, 2001), however, the exact mechanism remains Segawa and Shirahama (1987) 2,5-Cyclohexadiene-1,4-dione, 2-[(2E,6E,10E)-15-hydroxy-3,7,11,15-tetramethyl-14-oxo-2,6,10-hexadecatrien-1-yl]-6-methyl-S. micracanthum Mori et al (2005) 1,4-Benzenediol, 2-[(2E,6E,10E,14R)-14,15-dihydroxy-3,7,11,15-tetramethyl-2,6,10-hexadecatrien-1-yl]-6-methyl-S. micracanthum Mori et al (2005) 6,10,14-Hexadecatrien-3-one, 16-(2,5-dihydroxy-3-methylphenyl)-2-hydroxy-2,6,10,14-tetramethyl-, (6E,10E,14E)- Mori et al (2005) 9-Octadecenoic acid (9Z)-, 3-[(2E,6E,10E,14R)-14,15-dihydroxy-3,7,11,15-tetramethyl-2,6,10-hexadecatrien-1-yl]-4-hydroxy-5-methylphenyl ester S. micracanthum Mori et al (2005) Octadecanoic acid, 3-[(2E,6E,10E,14R)-14,15-dihydroxy-3,7,11,15-tetramethyl-2,6,10-hexadecatrien-1-yl]-4-hydroxy-5-methylphenyl ester S. micracanthum Mori et al (2005) 13-(3,4-dihydro-6-hydroxy-2,8-dimethy-2H-1-benzopyran-2-yl)-2,6,10-trimethyl-trideca-(2E,6E)-diene-4,5,10-triol.…”

Biological Importance of Marine Algae

“…Compound 181 displayed significant antioxidant activity while in contrast, 182 was potentely active against human cytomegalo virus (HCMV) in vitro (Iwashima et al, 2005). S. micracanthum (brown alga) was the source of strongly antioxidant plastoquinones 183-186, while compounds 184-186 showed antiproliferative effects against 26-L5 cells (Mori et al, 2005).…”