New phenylpropanoid and other compounds from Illicium lanceolatum with inhibitory activities against LPS-induced NO production in RAW 264.7 macrophages

Gui, Xuan; Wang, Guowei; Zhang, Naidan; Huang, Bao‐Kang

doi:10.1016/j.fitote.2014.02.015

Cited by 10 publications

(4 citation statements)

References 18 publications

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“…The anti-inflammatory effect of the developed formulation was assessed in acute inflammation method described with slight modifications. 40,41 Mice were transdermal administered with the formulation after 60 min, dimethyl benzene (40 μL per mouse) was applied to both surfaces of the right ear, and the left ear was used as the control. After 30 min of dimethyl benzene application, the mice were sacrificed by cervical dislocation.…”

Section: Dimethyl Benzene Induced Mice Ear Edemamentioning

confidence: 99%

<p>Berberine-Loaded Thiolated Pluronic F127 Polymeric Micelles for Improving Skin Permeation and Retention</p>

Niu¹,

Yuan²,

Chen³

et al. 2020

IJN

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Section: Dimethyl Benzene Induced Mice Ear Edemamentioning

confidence: 99%

<p>Berberine-Loaded Thiolated Pluronic F127 Polymeric Micelles for Improving Skin Permeation and Retention</p>

Niu¹,

Yuan²,

Chen³

et al. 2020

IJN

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“…The total ion chromatogram of EEIH in positive ion mode was shown in Figure S1. The MS/MS data were extracted from the raw data and manually interpreted based on the previous research [19,20,21,22,23,29,30,31,32,33,34,35,36,37]. A total of 24 peaks in EEIH were attributed to 31 compounds due to the presence of isomer.…”

Section: Resultsmentioning

confidence: 99%

Hepatoprotective Effect of the Ethanol Extract of Illicium henryi against Acute Liver Injury in Mice Induced by Lipopolysaccharide

Islam

Miao

et al. 2019

Antioxidants

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The root bark of Illicium henryi has been used in traditional Chinese medicine to treat lumbar muscle strain and rheumatic pain. Its ethanol extract (EEIH) has been previously reported to attenuate lipopolysaccharide (LPS)-induced acute kidney injury in mice. The present study aimed to evaluate the in vitro antioxidant activities and in vivo protective effects of EEIH against LPS-induced acute liver injury (ALI) in mice as well as explore its molecular mechanisms. The mice were injected intraperitoneally (i.p.) with EEIH at the doses of 1.25, 2.5, and 5.0 mg/kg every day for 5 days. One hour after the last administration, the mice were administered i.p. with LPS (8 mg/kg). After fasting for 12 h, blood and liver tissues were collected to histopathological observation, biochemical assay, enzyme-linked immunosorbent assay (ELISA), quantitative real-time polymerase chain reaction (qRT-PCR), and Western blot analyses. EEIH possessed 2,2-diphenyl-1-picrylhydrazil (DPPH) and 2,2′-azino-bis-(3-ethylbenzothiozoline-6-sulfonic acid) disodium salt (ABTS) radical scavenging activities and ferric-reducing antioxidant capacity in vitro. The histopathological examination, serum biochemical analysis, and liver myeloperoxidase (MPO) activity showed that EEIH pretreatment alleviated LPS-induced liver injury in mice. EEIH significantly dose-dependently decreased the mRNA and protein expression levels of inflammatory factors TNF-α, IL-1β, IL-6, and COX-2 in liver tissue of LPS-induced ALI mice via downregulating the mRNA and protein expressions of toll-like receptor 4 (TLR4) and inhibiting the phosphorylation of nuclear factor-κB (NF-κB) p65. Furthermore, EEIH markedly ameliorated liver oxidative and nitrosative stress burden in LPS-treated mice through reducing the content of thiobarbituric acid reactive substances (TBARS), inducible nitric oxide synthase (iNOS), and nitric oxide (NO) levels, restoring the decreased superoxide dismutase (SOD) and reduced glutathione (GSH) levels, and up-regulating nuclear factor erythroid 2 related factor 2 (Nrf2). These results demonstrate that EEIH has protective effects against ALI in mice via alleviating inflammatory response, oxidative and nitrosative stress burden through activating the Nrf2 and suppressing the TLR4/NF-κB signaling pathways. The hepatoprotective activity of EEIH might be attributed to the flavonoid compounds such as catechin (1), 3′,4′,7-trihydroxyflavone (2), and taxifolin (7) that most possibly act synergistically.

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“…We elected as target the naturally occurring and biologically relevant diaryl ether, named 3-methylobovatol 11 , and we report here its total synthesis based on zeolite-catalyzed steps (Scheme ). Isolated from Magnolia henryi and Illicium lanceolatum , known for the anti-inflammatory and analgesic activities of their extracts, this diaryl ether and its related analogs were found to exhibit an attractive array of biological activities . A single synthesis has so far been accomplished through a classical Ullmann coupling as the key step .…”

Section: Results and Discussionmentioning

confidence: 99%

Copper(I)–USY as a Ligand-Free and Recyclable Catalyst for Ullmann-Type O-, N-, S-, and C-Arylation Reactions: Scope and Application to Total Synthesis

et al. 2018

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The copper(I)-doped zeolite Cu-USY proved to be a versatile, efficient, and recyclable catalyst for various Ullmann-type coupling reactions. Easy to prepare and cheap, this catalytic material enables the arylation and heteroarylation of diverse O-, N-, S-, and C-nucleophiles under ligand-free conditions while exhibiting large functional group compatibility. The facility of this catalyst to promote C-O bond formation was further demonstrated with the total synthesis of 3-methylobovatol, a naturally occurring diaryl ether of biological relevance. From a mechanistic viewpoint, two competitive pathways depending on the nature of the nucleophile and consistent with the obtained results have been proposed.

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New phenylpropanoid and other compounds from Illicium lanceolatum with inhibitory activities against LPS-induced NO production in RAW 264.7 macrophages

Cited by 10 publications

References 18 publications

<p>Berberine-Loaded Thiolated Pluronic F127 Polymeric Micelles for Improving Skin Permeation and Retention</p>

<p>Berberine-Loaded Thiolated Pluronic F127 Polymeric Micelles for Improving Skin Permeation and Retention</p>

Hepatoprotective Effect of the Ethanol Extract of Illicium henryi against Acute Liver Injury in Mice Induced by Lipopolysaccharide

Copper(I)–USY as a Ligand-Free and Recyclable Catalyst for Ullmann-Type O-, N-, S-, and C-Arylation Reactions: Scope and Application to Total Synthesis

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