&lt;p&gt;Berberine-Loaded Thiolated Pluronic F127 Polymeric Micelles for Improving Skin Permeation and Retention&lt;/p&gt;

Niu, Jiangxiu; Yuan, Ming; Chen, Chenchen; Wang, Liye; Tang, Zigui; Fan, Yanli; Liu, Xianghui; Yu, Jianqun; Gan, Yu

doi:10.2147/ijn.s270336

Cited by 43 publications

(36 citation statements)

References 67 publications

(70 reference statements)

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“…More interestingly, the optimal ratio of chitosan-poloxamer conjugates and poloxamer for the most efficient skin penetration of drugs was 8:2, regardless of the type of chitosan. Poloxamers are surfactants that might increase flexibility and mechanical strength, leading to an enhanced permeability through an optimized ratio [ 9 , 45 , 46 ]. These results suggest that the penetration of the lipophilic model drug across the skin barrier was improved using CNSs composed of chitosan as an effective enhancer and poloxamer to improve skin permeability [ 13 , 37 , 45 , 46 ].…”

Section: Resultsmentioning

confidence: 99%

“…Poloxamers are surfactants that might increase flexibility and mechanical strength, leading to an enhanced permeability through an optimized ratio [ 9 , 45 , 46 ]. These results suggest that the penetration of the lipophilic model drug across the skin barrier was improved using CNSs composed of chitosan as an effective enhancer and poloxamer to improve skin permeability [ 13 , 37 , 45 , 46 ].…”

Section: Resultsmentioning

confidence: 99%

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A Novel Chitosan Nanosponge as a Vehicle for Transepidermal Drug Delivery

Lee

Kim

et al. 2021

Pharmaceutics

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Transepidermal drug delivery achieves high drug concentrations at the action site and ensures continuous drug delivery and better patient compliance with fewer adverse effects. However, drug delivery through topical application is still limited in terms of drug penetration. Chitosan is a promising enhancer to overcome this constraint, as it can enhance drug diffusion by opening the tight junctions of the stratum corneum. Therefore, here, we developed a novel chitosan nanosponge (CNS) with an optimal ratio and molecular weight of chitosan to improve drug penetration through skin. To prepare the CNS, two types of chitosan (3 and 10 kDa) were each conjugated with poloxamer 407 using para-nitrophenyl chloroformate, and the products were mixed with poloxamer 407 at ratios of 5:5, 8:2, and 10:0. The resulting mixtures were molded to produce flexible soft nanosponges by simple nanoprecipitation. The CNSs were highly stable in biological buffer for four weeks and showed no toxicity in human dermal fibroblasts. The CNSs increased drug permeability through human cadaver skin in a Franz-type diffusion cell, with substantially higher permeability with 3 kDa chitosan at a ratio of 8:2. This suggests the applicability of the novel CNS as a promising carrier for efficient transepidermal drug delivery.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

A Novel Chitosan Nanosponge as a Vehicle for Transepidermal Drug Delivery

Lee

Kim

et al. 2021

Pharmaceutics

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“…It remains in the tissue for a short time after 24 h because of drug metabolization and clearance. To overcome these issues, the development of targeted drug delivery based on nanotechnology presents a new approach for the loading and delivery of Ber to improve its bioavailability ( Wu et al, 2014 ; Mirhadi Rezaee, et al, 2018 ; Li et al, 2019 ; Lu et al, 2019 ; Niu et al, 2020 ). But Ber based on nanotechnology in asthma treatment has not been reported until now.…”

Section: Discussionmentioning

confidence: 99%

Berberine-Loaded Biomimetic Nanoparticles Attenuate Inflammation of Experimental Allergic Asthma via Enhancing IL-12 Expression

Jin

Zhang

et al. 2021

Front. Pharmacol.

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Asthma is one of the most common chronic pulmonary disorders, affecting more than 330 million people worldwide. Unfortunately, there are still no specific treatments for asthma so far. Therefore, it is very important to develop effective therapeutics and medicines to deal with this intractable disease. Berberine (Ber) has fabulous anti-inflammatory and antibacterial effects, while its low water solubility and bioavailability greatly limit its curative efficiency. To improve the nasal mucosa absorption of poorly water-soluble drugs, such as Ber, we developed a platelet membrane- (PM-) coated nanoparticle (NP) system (PM@Ber-NPs) for targeted delivery of berberine to the inflammatory lungs. In vivo, PM@Ber-NPs exhibited enhanced targeting retention in the inflammatory lungs compared with free Ber. In a mouse model of house dust mite- (HDM-) induced asthma, PM@Ber-NPs markedly inhibited lung inflammation, as evident by reduced inflammatory cells and inflammatory cytokines in the lung compared with free Ber. Collectively, our study demonstrated the inhibitory actions of nasally delivered nanomedicines on HDM-induced asthma, primarily through regulating Th1/Th2 balance by enhancing IL-12 expression which could potentially reduce lung inflammation and allergic asthma.

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“…Paclitaxel was effectively delivered to the tumor site with the help of the folic acid-hyaluronic acid-SS-vitamin E succinate polymer which enhanced selective targeted toxicity to the cancer cells without damaging healthy cells by analyzing cytotoxicity, apoptosis and cellular uptake studies in MCF-7 and NIH3T3 cells [ 18 ]. Studying the retention effects and skin penetration of thiolatedpluronic f127 polymeric micelles loaded with berberine using in vitro transdermic and fluorescence microscopy analysis showed that preparations enhanced the therapeutic benefit by decreasing the entry of drugsinto the systemic circulation, thereby preventing side effects and effectively treatinglocal skin diseases [ 19 ]. Curcumin, with effective anticancer potential, possess poor solubility and bioavailability and it was reported to be improved by using PEG–PLA copolymer micelles that act as an effective nanocarrier of curcumin, which could be used for treating non-small lung cancer cells [ 20 ].…”

Section: Types Of Nanoparticlesmentioning

confidence: 99%

Broad-Spectrum Theranostics and Biomedical Application of Functionalized Nanomaterials

Alshamrani

2022

Polymers

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Nanotechnology is an important branch of science in therapies known as “nanomedicine” and is the junction of various fields such as material science, chemistry, biology, physics, and optics. Nanomaterials are in the range between 1 and 100 nm in size and provide a large surface area to volume ratio; thus, they can be used for various diseases, including cardiovascular diseases, cancer, bacterial infections, and diabetes. Nanoparticles play a crucial role in therapy as they can enhance the accumulation and release of pharmacological agents, improve targeted delivery and ultimately decrease the intensity of drug side effects. In this review, we discussthe types of nanomaterials that have various biomedical applications. Biomolecules that are often conjugated with nanoparticles are proteins, peptides, DNA, and lipids, which can enhance biocompatibility, stability, and solubility. In this review, we focus on bioconjugation and nanoparticles and also discuss different types of nanoparticles including micelles, liposomes, carbon nanotubes, nanospheres, dendrimers, quantum dots, and metallic nanoparticles and their crucial role in various diseases and clinical applications. Additionally, we review the use of nanomaterials for bio-imaging, drug delivery, biosensing tissue engineering, medical devices, and immunoassays. Understandingthe characteristics and properties of nanoparticles and their interactions with the biological system can help us to develop novel strategies for the treatment, prevention, and diagnosis of many diseases including cancer, pulmonary diseases, etc. In this present review, the importance of various kinds of nanoparticles and their biomedical applications are discussed in much detail.

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<p>Berberine-Loaded Thiolated Pluronic F127 Polymeric Micelles for Improving Skin Permeation and Retention</p>

Cited by 43 publications

References 67 publications

A Novel Chitosan Nanosponge as a Vehicle for Transepidermal Drug Delivery

A Novel Chitosan Nanosponge as a Vehicle for Transepidermal Drug Delivery

Berberine-Loaded Biomimetic Nanoparticles Attenuate Inflammation of Experimental Allergic Asthma via Enhancing IL-12 Expression

Broad-Spectrum Theranostics and Biomedical Application of Functionalized Nanomaterials

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