New phenalenone derivatives from the Hawaiian volcanic soil-associated fungus Penicillium herquei FT729 and their inhibitory effects on indoleamine 2,3-dioxygenase 1 (IDO1)
“…In line with ongoing research endeavors focusing on the discovery of structurally new compounds and unique bioactive compounds, 7–11 we focused on investigating the presence of new metabolites in the MeOH extract of a plate culture of the fungus P. cornu-damae . In our recent study of P. cornu-damae , we successfully identified and isolated eight macrocyclic trichothecenes, namely miophytocen D, roridin E, roridin F, roridin L-2, satratoxin H, 12′-episatratoxin H, satratoxin I, and trichoverritone, including three previously unreported compounds (roridin F, miophytocen D, and satratoxin I).…”
A new dipeptide, N-hydroxy-Phe-Phe (1), and three macrocyclic trichothecenes, namely satratoxin H (2), 12′-episatratoxin H (3), and roridin F (4), were isolated from a plate culture of the poisonous mushroom Podostroma cornu-damae.
“…In line with ongoing research endeavors focusing on the discovery of structurally new compounds and unique bioactive compounds, 7–11 we focused on investigating the presence of new metabolites in the MeOH extract of a plate culture of the fungus P. cornu-damae . In our recent study of P. cornu-damae , we successfully identified and isolated eight macrocyclic trichothecenes, namely miophytocen D, roridin E, roridin F, roridin L-2, satratoxin H, 12′-episatratoxin H, satratoxin I, and trichoverritone, including three previously unreported compounds (roridin F, miophytocen D, and satratoxin I).…”
A new dipeptide, N-hydroxy-Phe-Phe (1), and three macrocyclic trichothecenes, namely satratoxin H (2), 12′-episatratoxin H (3), and roridin F (4), were isolated from a plate culture of the poisonous mushroom Podostroma cornu-damae.
The secondary metabolites isolated from soil fungi have received more and more attention, especially new compounds that exhibited good biological activities. In this review, a total of 546 new compounds are included in the relevant literature since 2011. The new compounds are isolated from soil fungi, We divided these compounds into seven categories, including alkaloids, terpenoids, steroids, ketones, phenylpropanoids, quinones, esters, lactones, etc. In addition, the biological activities and structure–activity relationships of these compounds have also been fully discussed. The activities of these compounds are roughly divided into eight categories, including anticancer activity, antimicrobial activity, anti-inflammatory activity, antioxidant activity, antiviral activity, antimalarial activity, immunosuppressive activity and other activities. Since natural products are an important source of new drugs, this review may have a positive guiding effect on drug screening.
“…Frontiers in Pharmacology frontiersin.org herqueinone has an IC 50 of 19.1 μM against IDO1, peniciherquinone inhibits IDO1 with IC 50 of 24.2 μM, and ent-12-methoxyisoherqueinone has an IC 50 of 32.6 μM against IDO1 (Yu et al, 2022). So far, the polyphenols only reported with moderate IDO1 inhibitory activities.…”
L-tryptophan metabolism is involved in the regulation of many important physiological processes, such as, immune response, inflammation, and neuronal function. Indoleamine 2, 3-dioxygenase 1 (IDO1) is a key enzyme that catalyzes the first rate-limiting step of tryptophan conversion to kynurenine. Thus, inhibiting IDO1 may have therapeutic benefits for various diseases, such as, cancer, autoimmune disease, and depression. In the search for potent IDO1 inhibitors, natural quinones were the first reported IDO1 inhibitors with potent inhibitory activity. Subsequently, natural compounds with diverse structures have been found to have anti-IDO1 inhibitory activity. In this review, we provide a summary of these natural IDO1 inhibitors, which are classified as quinones, polyphenols, alkaloids and others. The overview of in vitro IDO1 inhibitory activity of natural compounds will help medicinal chemists to understand the mode of action and medical benefits of them. The scaffolds of these natural compounds can also be used for further optimization of potent IDO1 inhibitors.
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