2017
DOI: 10.1590/0074-02760170098
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New perspectives on the nutritional factors influencing growth rate of Candida albicans in diabetics. An in vitro study

Abstract: BACKGROUND The link between Candida albicans and diabetes mellitus is well-acknowledged, but incompletely elucidated.OBJECTIVES The purpose of this study is to assess the growth rate of C. albicans (CA) in the presence of different concentrations of glucose and fructose, two of the main pathophysiologic and nutritionally relevant sugars in diabetic patients, in order to obtain a better understanding of the nutrient acquisition strategy and its possible relation to the hyperglycemic status of diabetic patients.… Show more

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Cited by 37 publications
(25 citation statements)
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“…C. albicans cells have the ability to modify their transcriptome by inhibiting the genes involved in gluconeogenesis, in the Krebs cycle or in the glyoxylate pathway, encouraging glycolysis and fermentation [ 86 ]. Other sugars such as fructose may change the outcome of an infection by increasing the generation time of Candida, thus inhibiting its growth rate [ 87 ].…”
Section: The Virulence Of Candida Sppmentioning
confidence: 99%
“…C. albicans cells have the ability to modify their transcriptome by inhibiting the genes involved in gluconeogenesis, in the Krebs cycle or in the glyoxylate pathway, encouraging glycolysis and fermentation [ 86 ]. Other sugars such as fructose may change the outcome of an infection by increasing the generation time of Candida, thus inhibiting its growth rate [ 87 ].…”
Section: The Virulence Of Candida Sppmentioning
confidence: 99%
“…in DM patients. Man et al [50] evaluated the growth rate of C. albicans in the presence of different concentrations of glucose and fructose to obtain a better understanding of the nutrient acquisition strategy and its possible relation to the hyperglycemic status of diabetic patients. The authors determined that the glucose concentration is directly related to C. albicans growth, which may be linked to the frequent yeast infections that occur in non-controlled diabetic patients.…”
Section: Introductionmentioning
confidence: 99%
“…This is an important outcome in oral Candida sp. biofilms, especially for patients who use prosthesis [50]. In fact, other carbon compounds such as sucrose, maltose, and lactose increase the fungal population density [43,51,52] and decrease the activity of antifungal agents.…”
Section: Introductionmentioning
confidence: 99%
“…A diet during the gestational period and in the 2 months following birth, therefore, during lactation, rich in L. rhamnosus and Bifidobacterium lactis brings beneficial effects on maternal health, fetal growth, and morbidity of the baby [15]. The same use of probiotics can guarantee, even in part, good bone regeneration and prevent mothers from any pathologies related to bone and dental loss [16], [17], [18].…”
Section: Discussionmentioning
confidence: 99%