New perspectives in tetracycline resistance

Salyers, Abigail A.; Speer, Brenda S.; Shoemaker, Nadja B.

doi:10.1111/j.1365-2958.1990.tb02025.x

Cited by 89 publications

(58 citation statements)

References 31 publications

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“…This antibiotic remained a useful antianaerobic agent until the early 1970s (134); today, nearly all clinical isolates of Bacteroides are resistant (80 to 90%). tetQ is one of several tetracycline resistance genes that codes for a cytoplasmic protein that interacts with the ribosome, making it insensitive to tetracycline blocking (232). TetQ is the most common type of tetracycline resistance in Bacteroides (140).…”

Section: Continued On Facing Pagementioning

confidence: 99%

Bacteroides: the Good, the Bad, and the Nitty-Gritty

2007

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SUMMARY Summary: Bacteroides species are significant clinical pathogens and are found in most anaerobic infections, with an associated mortality of more than 19%. The bacteria maintain a complex and generally beneficial relationship with the host when retained in the gut, but when they escape this environment they can cause significant pathology, including bacteremia and abscess formation in multiple body sites. Genomic and proteomic analyses have vastly added to our understanding of the manner in which Bacteroides species adapt to, and thrive in, the human gut. A few examples are (i) complex systems to sense and adapt to nutrient availability, (ii) multiple pump systems to expel toxic substances, and (iii) the ability to influence the host immune system so that it controls other (competing) pathogens. B. fragilis, which accounts for only 0.5% of the human colonic flora, is the most commonly isolated anaerobic pathogen due, in part, to its potent virulence factors. Species of the genus Bacteroides have the most antibiotic resistance mechanisms and the highest resistance rates of all anaerobic pathogens. Clinically, Bacteroides species have exhibited increasing resistance to many antibiotics, including cefoxitin, clindamycin, metronidazole, carbapenems, and fluoroquinolones (e.g., gatifloxacin, levofloxacin, and moxifloxacin).

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Section: Continued On Facing Pagementioning

confidence: 99%

Bacteroides: the Good, the Bad, and the Nitty-Gritty

2007

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“…Four of these isolates were studied further and found to harbour plasmids that did not hybridize with the tet(S) probe, suggesting that the resistance gene was located in the chromosome. In Gram-positive bacteria, tetracycline resistance genes are borne by a variety of mobile genetic elements including transposons, both conjugative and non-conjugative, and self-transferable plasmids (Salyers et al, 1990(Salyers et al, , 1995Courvalin & Carlier, 1986;Bedzyk et al, 1992).…”

Section: Introductionmentioning

confidence: 99%

Conjugative transfer of tet(S) between strains of Enterococcus faecalis is associated with the exchange of large fragments of chromosomal DIMA

Francois¹,

Charles

Courvalin

1997

Microbiology

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The tetracycline resistance determinant tet(S) was first detected in antibiotic multiresistant Listeria monocytogenes BM4210 and subsequently in strains of Enterococcus faecalis. Transfer of tet(S) from clinical isolate E. faecalis BM4242 to E. faecalis strains JH2-2 and OGlRF was found to require the presence in the donor strain of the 55 kb conjugative plasmid plP825. Comparison of restriction endonuclease generated maps of the donor, the two recipients, and of four transconjugants indicated that transfer of tet(S) (i) was from chromosome to chromosome, (ii) resulted in the acquisition of an approximately 40 kb element in the same chromosomal region and (iii) was associated with the exchange of large chromosomal fragments. Similar observations were made following conjugal transfer of tet(S) from four other E. faecalis clinical isolates. ~~

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“…Tetracycline resistance genes have been grouped into 12 classes based on their failure to cross-hybridize under stringent conditions [18,19]. In Gram-negative bacteria, the outer membrane exhibits a strong permeability barrier to many lipophilic compounds and the primary mechanism of tetracycline resistance is based on active efflux of the drug [20].…”

Section: Transport Properties Of Orctl2mentioning

confidence: 99%

Functional characterization of ORCTL2 ‐ an organic cation transporter expressed in the renal proximal tubules

et al. 1998

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Chromosome 11p15.5 harbors a gene or genes involved in Beckwith-Wiedemann syndrome that confer(s) susceptibility to Wilms' tumor, rhabdomyosarcoma, and hepatoblastoma. We have previously identified a transcript at 1 lp15.5 which encodes a putative membrane transport protein, designated organic cation transporter-like 2 (ORCTL2), that shares homology with tetracycline resistance proteins and bacterial multidrug resistance proteins. In this report, we have investigated the transport properties of ORCTL2 and show that this protein can confer resistance to ehloroquine and quinidine when overexpressed in bacteria. Immunohistochemistry analyses performed with anti-ORCTL2 polycional antibodies on human renal sections indicate that ORCTL2 is localized on the apical membrane surface of the proximal tubules. These results suggest that ORCTL2 may play a role in the transport of chloroquine and quinidine related compounds in the kidney.

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New perspectives in tetracycline resistance

Cited by 89 publications

References 31 publications

Bacteroides: the Good, the Bad, and the Nitty-Gritty

Bacteroides: the Good, the Bad, and the Nitty-Gritty

Conjugative transfer of tet(S) between strains of Enterococcus faecalis is associated with the exchange of large fragments of chromosomal DIMA

Functional characterization of ORCTL2 ‐ an organic cation transporter expressed in the renal proximal tubules

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