New Perspective of GABA as an Inhibitor of Formation of Advanced Lipoxidation End-Products: It's Interaction with Malondiadehyde

Deng, Yan; Xu, Lijian; Xin, Zeng; Li, Zhiyang; Qin, Binbing; He, Nongyue

doi:10.1166/jbn.2010.1130

Cited by 52 publications

(32 citation statements)

References 53 publications

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“…11), consistent with previous studies [60][61]23]. GABA was suggested to act as an inhibitor of MDA formation during lipid peroxidation [62]. Liu et al found that GABA exhibits ROS scavenging ability and can contribute to alleviating stress [63], although studies are required to determine whether GABA can directly scavenge ROS to relieve stress.…”

Section: Discussionsupporting

confidence: 85%

Gamma-aminobutyric acid (GABA) alleviates salt damage in tomato by modulating Na+ uptake, the GAD gene, amino acid synthesis and reactive oxygen species metabolism

Jia

et al. 2020

Preprint

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Background: Salt stress is a serious abiotic stress that caused crop growth inhibition and yield decline. Previous studies have reported on the the synthesis of gamma-aminobutyric acid (GABA) and its relationship with plant resistance under various abiotic stress. However, the relationship between exogenous GABA alleviating plant salt stress damage and ion flux, amino acid synthesis, and key enzyme expression remains largely unclear. We investigated plant growth, Na+ transportation and accumulation, reactive oxygen species (ROS) metabolism and evaluated the effect of GABA on amino acids especially SlGADs gene expression and the endogenous GABA content of tomato (Solanum lycopersicum L.) seedlings treated with or without 5 mmol·L-1 GABA under 175 mmol·L-1 NaCl stress. Results: Exogenous application of GABA significantly reduced the salt damage index and increased plant height, chlorophyll content and the dry and fresh weights of tomato plants exposed to NaCl stress. GABA significantly reduced Na+ accumulation in leaves and roots by preventing Na+ influx in roots and transportation to leaves. The transcriptional expression of SlGAD1-3 genes were induced by NaCl stress especially with GABA application. Among them, SlGAD1 expression was the most sensitive and contributed the most to the increase in glutamic acid decarboxylase (GAD) activity induced by NaCl and GABA application; Exogenous GABA increased GAD activity and amino acid contents in tomato leaves compared with the levels under NaCl stress alone, especially the levels of endogenous GABA, proline, glutamate and eight other amino acids. These results indicated that SlGADs transcriptional expression played an important role in tomato plant resistance to NaCl stress with GABA application by enhancing GAD activity and amino acid content. GABA significantly alleviated the active oxygen-related injury of leaves under NaCl stress by increasing the activities of antioxidant enzymes and decreasing the contents of active oxygen species and malondialdehyde.Conclusion: Exogenous GABA had a positive effect on the resistance of tomato seedlings to salt stress, which was closely associated with reducing Na+ flux from root to leaves, increasing amino acid content and strengthening antioxidant metabolism. Endogenous GABA content was induced by salt and exogenous GABA at both the transcriptional and metabolic levels.

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Section: Discussionsupporting

confidence: 85%

Gamma-aminobutyric acid (GABA) alleviates salt damage in tomato by modulating Na+ uptake, the GAD gene, amino acid synthesis and reactive oxygen species metabolism

Jia

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…Also, lipid peroxidation by activation of LOX, which can be evaluated by MDA, is responsible for loss of cell membrane integrity (Wise and Naylor, 1987). GABA was suggested to act as an inhibitor of MDA formation during lipid peroxidation (Deng et al, 2010). A higher tolerance to chilling stress, evidenced by the slower increase of MDA content and electrolyte leakage, was observed in the spathe of anthurium cut flowers treated with GABA at pre and postharvest stage.…”

Section: Discussionmentioning

confidence: 95%

Amelioration of postharvest chilling injury in anthurium cut flowers by γ-aminobutyric acid (GABA) treatments

Aghdam

Naderi

Sarcheshmeh

et al. 2015

Postharvest Biology and Technology

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“…The antioxidant effect of GABA has been widely investigated in animals. Direct evidence has shown that GABA can trap the reactive intermediates during lipid peroxidation and suggests that the scavenging effects of GABA on reactive carbonyl compounds may play an important role in inhibiting the formation of advanced lipoxidation end‐products (Deng et al ). Previous studies showed that injection with a dose of 500 mg/kg GABA could increase the activities of SOD in rats (Deng et al ).…”

Section: Discussionmentioning

confidence: 99%

Effects of Dietary Gamma Aminobutyric Acid on Growth Performance, Antioxidant Status, and Feeding‐related Gene Expression of Juvenile Grass Carp, Ctenopharyngodon idellus

Liu

Chen

et al. 2016

J World Aquaculture Soc

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Gamma aminobutyric acid (GABA) is one of the inhibitory neurotransmitters that may have the ability to regulate the appetite. This study aimed to evaluate the effects of dietary GABA, as a feed additive, on growth performance and antioxidant status of juvenile grass carp. Five isonitrogenous and isoenergetic experimental diets with graded levels of GABA (0, 20, 50, 100 and 200 mg/kg) were fed to grass carp juveniles (mean weight: 2.0 g) for 8 wk. The results showed that the specific growth rate (SGR) increased significantly with dietary GABA level up to the 100 mg/kg diet, and then decreased in the 200 mg/kg group (P < 0.05). The difference in SGR value between the 50 and 100 mg/kg groups was not statistically significant (P > 0.05). The survival rate was not significantly affected by dietary GABA level (P > 0.05). No significant difference was observed in the whole body composition among treatments (P > 0.05). The hepatopancreatic glutathione peroxidase (GPx) activity increased significantly (P < 0.05) with the GABA level, peaked in the group with GABA 100 mg/kg, and then decreased. The hepatopancreatic superoxide dismutase and total antioxidant capacity activities showed the same trend as GPx. Inversely, the hepatopancreatic malondialdehyde content decreased first and then increased with the dietary GABA level (P < 0.05). No significant differences were observed in the gene expression of neuropeptide Y (NPY), cholecystokinin, leptin, and ghrelin in the hepatopancreas among groups. However, the NPY and ghrelin mRNA expression levels in the brain increased significantly with the GABA level, peaked in the groups of 50 mg/kg, and then showed a decreasing trend. On the basis of quadratic regression analysis of SGR, the optimum content of dietary GABA in juvenile grass carp is suggested to be a 87.5 mg/kg diet.

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New Perspective of GABA as an Inhibitor of Formation of Advanced Lipoxidation End-Products: It's Interaction with Malondiadehyde

Cited by 52 publications

References 53 publications

Gamma-aminobutyric acid (GABA) alleviates salt damage in tomato by modulating Na+ uptake, the GAD gene, amino acid synthesis and reactive oxygen species metabolism

Gamma-aminobutyric acid (GABA) alleviates salt damage in tomato by modulating Na+ uptake, the GAD gene, amino acid synthesis and reactive oxygen species metabolism

Amelioration of postharvest chilling injury in anthurium cut flowers by γ-aminobutyric acid (GABA) treatments

Effects of Dietary Gamma Aminobutyric Acid on Growth Performance, Antioxidant Status, and Feeding‐related Gene Expression of Juvenile Grass Carp, Ctenopharyngodon idellus

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