1995
DOI: 10.1248/cpb.43.872
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New Oral Dosage Form for Elderly Patients. II. Release Behavior of Benfotiamine from Silk Fibroin Gel.

Abstract: Silk fibroin gel (SFG) containing benfotiamine (BTMP) was prepared. The release behavior of BTMP from SFG was studied as a function of silk fibroin (SF) content and glycerol content, and the influence of the existence of beta-cyclodextrin (beta-CD) on the physicochemical properties of SFG were investigated. The release rate of BTMP from SFG was retarded by an increase in SF concentration. The addition of beta-CD affected both the release properties and rheological properties of the SFG. It was found from the r… Show more

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Cited by 47 publications
(31 citation statements)
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“…It is also available for similar indications as a homeopathic medicine and as a dietary supplement. The typical oral dose recommended is 40-450 mg/day [63,64]. The topical application of benfotiamine may allow more prodrug to be introduced into the target tissues and, as a result, potentially generate a greater therapeutic effect.…”
Section: Introductionmentioning
confidence: 99%
“…It is also available for similar indications as a homeopathic medicine and as a dietary supplement. The typical oral dose recommended is 40-450 mg/day [63,64]. The topical application of benfotiamine may allow more prodrug to be introduced into the target tissues and, as a result, potentially generate a greater therapeutic effect.…”
Section: Introductionmentioning
confidence: 99%
“…Silk fibroin (SF) consists of heavy chain (~390 kDa) and light chain (~25 kDa) polypeptides linked by a disulfide bond (Zhou et al, 2001). Many researchers consider that silk is one of the promising materials for application in delivery of hydrophobic drugs and enzymes (Hanawa et al, 1995;Oh and Lee, 2013;Kuzuhara et al, 1987).…”
Section: Introductionmentioning
confidence: 99%
“…Traditionally, silkworm cocoon has been used to make a textile fiber and surgical suture for several thousand years. Recently useful biological properties of silk protein have been reported by researchers; acceleration of collagen formation, and proliferation of cultured human skin fibroblasts (Yeo et al, 2000;Yamada et al, 2004), matrix for mammalian cell culture and enzyme immobilization (Minoura et al, 1995), scaffold for bone substitution (Sofia et al, 2001), and drug delivery carrier (Hanawa et al, 1995), oxygen and water vapor permeability Minoura et al, 1990;Kweon et al, 2001, and blood compatibility (Sakabe et al, 1989).…”
Section: Introductionmentioning
confidence: 99%