New optofluidic based lab-on-a-chip device for the real-time fluoride analysis

Bhat, Mahesh P.; Kurkuri, Mahaveer D.; Lošić, Dušan; Kigga, Madhuprasad; Altalhi, Tariq

doi:10.1016/j.aca.2021.338439

Cited by 29 publications

(11 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Optofluidic sensor platforms are being intensely studied for their unique combination of optical precision and sensitivity and lab-on-a-chip ease-of-use and efficiency [1][2][3]. Many recently reported optofluidic devices exploit the straight-forward integration of optical components (light emitting diodes, lenses, optical filters) and fluidics (microfluidic channels, capillaries, droplets) [4][5][6]. However, some of the most promising optical and fluidic phenomena are not easily integrated, due to incompatibility of physical or chemical constraints, and, when achieved, are anchored to the laboratory by the necessary infrastructure [7].…”

Section: Introductionmentioning

confidence: 99%

Caged-Sphere Optofluidic Sensors: Whispering Gallery Resonators in Wicking Microfluidics

Riesen

Peterkovic

Guan

et al. 2022

Sensors

View full text Add to dashboard Cite

The rapid development of optofluidic technologies in recent years has seen the need for sensing platforms with ease-of-use, simple sample manipulation, and high performance and sensitivity. Herein, an integrated optofluidic sensor consisting of a pillar array-based open microfluidic chip and caged dye-doped whispering gallery mode microspheres is demonstrated and shown to have potential for simple real-time monitoring of liquids. The open microfluidic chip allows for the wicking of a thin film of liquid across an open surface with subsequent evaporation-driven flow enabling continuous passive flow for sampling. The active dye-doped whispering gallery mode microspheres placed between pillars, avoid the use of cumbersome fibre tapers to couple light to the resonators as is required for passive microspheres. The performance of this integrated sensor is demonstrated using glucose solutions (0.05–0.3 g/mL) and the sensor response is shown to be dynamic and reversible. The sensor achieves a refractive index sensitivity of ~40 nm/RIU, with Q-factors of ~5 × 103 indicating a detection limit of ~3 × 10−3 RIU (~20 mg/mL glucose). Further enhancement of the detection limit is expected by increasing the microsphere Q-factor using high-index materials for the resonators, or alternatively, inducing lasing. The integrated sensors are expected to have significant potential for a host of downstream applications, particularly relating to point-of-care diagnostics.

show abstract

Section: Introductionmentioning

confidence: 99%

Caged-Sphere Optofluidic Sensors: Whispering Gallery Resonators in Wicking Microfluidics

Riesen

Peterkovic

Guan

et al. 2022

Sensors

View full text Add to dashboard Cite

show abstract

“…In order to produce this sensor family for health care, pathogen detection, and clinical reasons, many fabrication processes have been developed throughout the years. [13][14][15][16] Wearable technology has grown in three phases, according to early studies: a first phase from the 1980s to 1997; a second phase between 1998 and 2000; and a third phase between 2001 and 2004. 17 It is described as follows: the first period is driven by technology, with an emphasis on wearable computing applications; the second is a period of integration with the fashion and textiles sector, with more extensive garment integration; and the third is a period of growth in smart clothing and garment integration in the commercial sector.…”

Section: Wearable Healthcare Devices and Their Historical Perspectivementioning

confidence: 99%

Advancements and future prospects of wearable sensing technology for healthcare applications

et al. 2022

View full text Add to dashboard Cite

show abstract

“…On the other hand, sensors would be ideal for the detection of these rare CTCs. Currently, several techniques such as flow cytometry, enzyme-linked immunosorbent assay (ELISA), Western blotting, quantitative polymerase chain reaction (Q-PCR), magnetic-activated cell sorting (MACS), fluorescence-activated cell sorting (FACS) and centrifugation techniques, and laserbased technology are widely used for the biomolecular or cellular analysis of cancer [18][19][20][21][22][23][24][25][26]. Although these techniques have several limitations, such as substantial sample consumption, low throughput, lack of real-time monitoring, and high overall operational expenses, there are no other alternative simple techniques available for CTC isolation.…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in Microfluidic Platform for Physical and Immunological Detection and Capture of Circulating Tumor Cells

et al. 2022

Self Cite

View full text Add to dashboard Cite

CTCs (circulating tumor cells) are well-known for their use in clinical trials for tumor diagnosis. Capturing and isolating these CTCs from whole blood samples has enormous benefits in cancer diagnosis and treatment. In general, various approaches are being used to separate malignant cells, including immunomagnets, macroscale filters, centrifuges, dielectrophoresis, and immunological approaches. These procedures, on the other hand, are time-consuming and necessitate multiple high-level operational protocols. In addition, considering their low efficiency and throughput, the processes of capturing and isolating CTCs face tremendous challenges. Meanwhile, recent advances in microfluidic devices promise unprecedented advantages for capturing and isolating CTCs with greater efficiency, sensitivity, selectivity and accuracy. In this regard, this review article focuses primarily on the various fabrication methodologies involved in microfluidic devices and techniques specifically used to capture and isolate CTCs using various physical and biological methods as well as their conceptual ideas, advantages and disadvantages.

show abstract

New optofluidic based lab-on-a-chip device for the real-time fluoride analysis

Cited by 29 publications

References 30 publications

Caged-Sphere Optofluidic Sensors: Whispering Gallery Resonators in Wicking Microfluidics

Caged-Sphere Optofluidic Sensors: Whispering Gallery Resonators in Wicking Microfluidics

Advancements and future prospects of wearable sensing technology for healthcare applications

Recent Advances in Microfluidic Platform for Physical and Immunological Detection and Capture of Circulating Tumor Cells

Contact Info

Product

Resources

About