New‐onset pemphigus foliaceus following SARS‐CoV‐2 infection and unmasking multiple sclerosis: A case report

Abstract

Development of pemphigus foliaceus (PF) following SARS-CoV-2 infection has only been reported in one patient who had received Bamlanivimab and thus might be considered as a drug-induced case of PF. Here, we reported the first case of PF arising solely after COVID infection without taking any culprit drug.

Two asymptomatic facial erythematous macules in an adult male

“…Systemic corticosteroids are still the mainstay and first‐line treatment of pemphigus. However, in moderate‐to‐severe cases, oral azathioprine or a mycophenolate compound is added 7 . Based on the benign and limited course of disease in our patient, a topical corticosteroid was initiated for him, which led to complete resolution of skin lesions in 2 months.…”

COVID outcome in pemphigus: Does rituximab make pemphigus patients susceptible to more severe COVID‐19?

“…1 Moreover, this infection has led to exacerbation of many dermatoses, including psoriasis, lichen planus, and pemphigus. 2,3 Therapeutics chosen to manage the infection have also had dermatologic adverse events. 4 Finally, COVID vaccines have given rise to many new-onset or flares of dermatologic disorders.…”

COVID‐19 vaccines and filler reactions: Should it be considered as a concern?

“…Since the beginning of the coronavirus disease 2019 (COVID- 19) pandemic, abundant cases of dermatologic reactions have been reported in the settings of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection which many of them have been the result of exacerbation of previously recognized dermatoses, while the new-onset adverse events have not been uncommon. 1,2 With progresses made in cosmetic dermatology and surgery, a great majority of the world population are being interested in cosmetic and aesthetic procedures, particularly minimally invasive ones. Liposuction, dermal filler injection, platelet rich plasma treatment (PRP), mesotherapy, microdermabrasion, ablative resurfacing lasers, and botulinum toxin injection are among the related procedures.…”

“…Since the beginning of the coronavirus disease 2019 (COVID‐19) pandemic, abundant cases of dermatologic reactions have been reported in the settings of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection which many of them have been the result of exacerbation of previously recognized dermatoses, while the new‐onset adverse events have not been uncommon 1,2 …”