<scp>COVID</scp>‐19 vaccines and filler reactions: Should it be considered as a concern?

Aryanian, Zeinab; Balighi, Kamran; Emadi, Seyed Naser; Razavi, Zahra; Hatami, Parvaneh; Afshar, Zeinab Mohseni

doi:10.1111/jocd.15428

Cited by 3 publications

(2 citation statements)

References 46 publications

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“…Patients who have received prosthetic implants or filler injections may choose a vaccine with a relatively low incidence of adverse reactions and be closely monitored for any immune reactions associated with the implant after receiving the vaccine. If adverse reactions occur after the first dose of the vaccine, we can take preventive measures such as pretreatment with antihistamines or corticosteroids before the patient receives the second or third dose 86 . As for the general people, Rice et al 42 recommends they need to wait at least 4–8 weeks after vaccination before receiving cosmetic implants because it takes 3 weeks for the immune response to peak.…”

Section: Discussionmentioning

confidence: 99%

“…If adverse reactions occur after the first dose of the vaccine, we can take preventive measures such as pretreatment with antihistamines or corticosteroids before the patient receives the second or third dose. 86 As for the general people, Rice et al 42 recommends they need to wait at least 4-8 weeks after vaccination before receiving cosmetic implants because it takes 3 weeks for the immune response to peak. The Waiting time interval may be longer for those at risk for autoimmune disease, those taking chemotherapy or immunomodulatory drugs, and those with a history of allergy to implants to minimize the risk of reactions.…”

Section: Prevention and Recommendationsmentioning

confidence: 99%

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Adverse reactions to cosmetic implants after COVID‐19 vaccination: A literature review

Cheng,

Cai,

Tang

2023

J of Cosmetic Dermatology

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BackgroundAs the world's population of people vaccinated with the COVID‐19 vaccine increases, adverse reactions are increasingly being reported. There have been progressive reports of the effects of COVID‐19 vaccination on cosmetic fillers or prostheses, but they have not been reviewed based on their clinical morphologic patterns. This article reviewed the progress of research on adverse reactions to cosmetic implants after COVID‐19 vaccination.MethodsWe researched the English‐language literature up to October 15, 2022, using predefined keywords to identify relevant studies about adverse reactions to cosmetic implants after the COVID‐19 vaccination, collecting patient characteristics, implant type, the time interval between vaccination and implantation or injection, time of onset, symptoms, treatments, and outcomes.ResultsAmong the adverse reactions to implants associated with COVID‐19 vaccination, we distinguished between (1) injectable fillers and (2) surgical prosthetic implants. The most common adverse reactions were at the site of hyaluronic acid injection and breast prosthesis after Pfizer vaccination, mainly DIRs, and mainly manifested as edema, rash, fever, and capsular contracture. This paper also reported the possible causes, treatments of DIRs, and limitations of current studies.ConclusionsIn this article, we attempted to investigate and discuss all the adverse reactions of cosmetic implants related to COVID‐19 vaccination in the current literature, to unmask these reactions and make a more accurate assessment of vaccine safety.

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Section: Discussionmentioning

confidence: 99%

Section: Prevention and Recommendationsmentioning

confidence: 99%

Adverse reactions to cosmetic implants after COVID‐19 vaccination: A literature review

Cheng,

Cai,

Tang

2023

J of Cosmetic Dermatology

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Facial Dermal Filler Injection and Vaccination: A 12-Year Review of Adverse Event Reporting and Literature Review

Sun¹,

Tiongco²,

Manahan³

2023

Aesthetic Surgery Journal

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Background Following authorization of two COVID-19 vaccinations in December 2020, media attention increased towards post-vaccine adverse events (AEs) in patients with facial dermal filler injections. Objectives The purpose was to characterize vaccine-related facial dermal filler AEs using the FDA’s Manufacturer and User Facility Device Experience (MAUDE) database. Methods The MAUDE database was queried from January 1, 2011 to January 28, 2023 for facial dermal filler reports discussing vaccination-related AEs. A PubMed (National Institutes of Health, Bethesda, MD) literature review on dermal filler AEs was then conducted. Data were analyzed with descriptive statistics. Results Of 10,637 reports identified, 33 were included. There were 25 reports (75.8%) related to COVID-19 vaccination. Six reports (18.1%) were received before December 2020. There were 13 reports (39.4%) from February to June 2021 and 14 (42.4%) from September to December 2022. Hyaluronic acid-based fillers were described in 31 reports (93.9%). AEs were mostly reported within days post-injection (n=7, 21.2%), but ranged from immediately (n=2, 6.1%) to months (n=6, 18.2%) post-injection. Most AEs were reported post-vaccine (n=17, 51.5%) versus post-filler (n=14, 42.4%). In 26 reports (78.8%), AEs occurred at the site of filler injection. Most reports described inflammation/swelling (n=21, 28.0%). The literature review returned 302 articles, of which 14 were included. Only 1 article (7.1%) was published in a plastic surgery journal. Conclusions While the pandemic brought attention to COVID-19 vaccine-related facial dermal filler AEs, our study shows a low incidence compared to millions of vaccine and filler injections administered. The authors also document reactions with non-COVID-19 vaccines. Increased awareness may help providers counsel patients undergoing vaccination and dermal filler implantation.

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Hyaluronic Acid in Facial Rehabilitation—A Narrative Review

2023

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Background: Hyaluronic acid fillers (HAF) are a versatile tool in esthetic medicine. They also have a potential for medical indications including facial rehabilitation. Materials and methods: We performed a literature search on PUBMED and Google Scholar until December 2022. Clinical trials, clinical studies, review articles, systematic reviews, meta-analyses, case series, and case reports were considered for review. Keywords “facial rehabilitation”, “acne scars”, “traumatic scars”, “oral restoration”, “facial lipoatrophy”, “facial asymmetry”, “periocular correction”, “nasal obstruction”, “ear lobe restoration”, “morphea”, AND “hyaluronic acid filler” were used to select articles. Results: We prepared a narrative review on the use of HAF for correction of facial asymmetry and asymmetric lips, improvement of different types of scars, improvement of the jaw line, improvement of ear lobes, periocular and oral restoration, and the treatment of nasal obstruction and morphea en coub de sabre. The amount of HA used in these indications is often less than 1 mL. The bolus technique, fanning, and dual-plane injections can be utilized for treatment. Duration of clinical effects depends upon the anatomical region and is usually maintained between 2 months and 2 years. Adverse events are often mild and temporary. Vascular occlusion is a severe adverse event, but it has not been reported yet for these medical indications. Repeated injections are recommended to obtain a longer-lasting improvement. In cases of morphea, only stable and non-inflammatory plaques should be treated. The advantage of HAF compared to permanent and semipermanent fillers is the availability of hyaluronidase for rapid removal of filler material and to revise overcorrection. Conclusions: HAF play an auxiliary role in facial rehabilitation. Knowledge of filler qualities, anatomy, and underlying diagnoses is important for their safe application. More prospective controlled trials are necessary to improve evidence.

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COVID‐19 vaccines and filler reactions: Should it be considered as a concern?

Cited by 3 publications

References 46 publications

Adverse reactions to cosmetic implants after COVID‐19 vaccination: A literature review

Adverse reactions to cosmetic implants after COVID‐19 vaccination: A literature review

Facial Dermal Filler Injection and Vaccination: A 12-Year Review of Adverse Event Reporting and Literature Review

Hyaluronic Acid in Facial Rehabilitation—A Narrative Review

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