2021
DOI: 10.3390/ijerph18136961
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New Onset of Hepatic Steatosis Post-Severe Multisystem Inflammatory Syndrome in Children (MIS-C): A Case Report

Abstract: The emergence of Multisystem Inflammatory Syndrome (MIS-C) following SARS-CoV-2 infection in children and adolescents provided a new diagnostic and management challenge as there is limited knowledge about this condition and its natural history. In existing literature on MIS-C, there are currently no data about long-term outcomes. We report the case of a 14-year-old boy, with no significant past medical history, who presented a condition of multiorgan dysfunction due to MIS-C, after a SARS CoV-2 infection, and … Show more

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Cited by 9 publications
(5 citation statements)
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“…Laboratory findings of our case are in keeping with similar publications on leukopenia and thrombocytopenia [ 20 , 62 , 63 ] high ferritin, abnormal D-dimer, and elevated troponin [ 20 , 46 , 64 , 65 ]. In contrast to other findings, acute kidney injury (AKI) [ 64 , 66 69 ], prolonged coagulation profile, abnormal fibrinogen, and abnormal liver function[ 70 73 ] were not observed in our case.…”
Section: Discussioncontrasting
confidence: 99%
“…Laboratory findings of our case are in keeping with similar publications on leukopenia and thrombocytopenia [ 20 , 62 , 63 ] high ferritin, abnormal D-dimer, and elevated troponin [ 20 , 46 , 64 , 65 ]. In contrast to other findings, acute kidney injury (AKI) [ 64 , 66 69 ], prolonged coagulation profile, abnormal fibrinogen, and abnormal liver function[ 70 73 ] were not observed in our case.…”
Section: Discussioncontrasting
confidence: 99%
“…Giannattasio et al [ 53 ] reviewed 55 pediatric patients (mean age 6.5 ± 3.7 years) with MIS-C and showed that 16 patients had acute liver injury (ALI) at admission and 10 more patients developed ALI during observation, ALI was defined by the presence of ALT elevation > 40 U/L. Furthermore, a 14-year-old boy developed MIS-C after SARS-COV-2 infection which was followed by hepatic steatosis, and the researchers also found elevated levels of ALT, AST and indices of cholestasis[ 54 ]. Another 10-month-old boy developed fulminant acute liver failure due to MIS-C[ 55 ].…”
Section: Indirect Pathophysiological Mechanismsmentioning
confidence: 99%
“…This indicates the presence of acute hepatitis with clinical jaundice without biliary obstruction in SARS-CoV-2 infection. 5 Sica et al demonstrated a new onset of hepatic steatosis in a 14-year-old boy patient with SARS-CoV-2 infection, which may be one of the sequelae of severe manifestations of COVID-19, known as MIS-C. 17 Fulminant acute hepatitis was also declared in an The acute liver laceration was found in confirmed COVID-19 infants aged 55 days, with recorded AST levels of 100 U/dL, ALT 84 U/dL, total bilirubin 33.7 mg/dL, and direct 25.2 mg/dL. 18 Moreover, Zhu et al mentioned that 2 of 10 newborns from mothers with confirmed COVID-19 had elevated liver enzyme levels.…”
Section: Manifestations Of Liver Injury In Pediatric Covid-19 Patientsmentioning
confidence: 99%