New-Onset Diabetes Mellitus and the Analysis of Dipeptidyl-Peptidase-4 After Liver Transplantation

Gámán, György; Sárváry, Enikő; Gelley, Fanni; Doros, Attila; Görög, Dénes; Fehérvári, Imre; Kopper, László; Wagner, László; Nemes, Balázs

doi:10.1016/j.transproceed.2014.05.062

Cited by 9 publications

(2 citation statements)

References 12 publications

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“…Interest in DPP-4 inhibitors for the management of PTLDM has surged in recent years, as incretins counteract the diabetogenic actions of immunosuppressant drugs [ 141 ]. Notably, increased levels of DPP-4 have been reported in LT patients with HCV but not other etiologies [ 142 ].…”

Section: Management Of Pltdmmentioning

confidence: 99%

Post-Liver Transplantation Diabetes Mellitus: A Review of Relevance and Approach to Treatment

et al. 2018

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Post-liver transplantation diabetes mellitus (PLTDM) develops in up to 30% of liver transplant recipients and is associated with increased risk of mortality and multiple morbid outcomes. PLTDM is a multicausal disorder, but the main risk factor is the use of immunosuppressive agents of the calcineurin inhibitor (CNI) family (tacrolimus and cyclosporine). Additional factors, such as pre-transplant overweight, nonalcoholic steatohepatitis and hepatitis C virus infection, may further increase risk of developing PLTDM. A diagnosis of PLTDM should be established only after doses of CNI and steroids are stable and the post-operative stress has been overcome. The predominant defect induced by CNI is insulin secretory dysfunction. Plasma glucose control must start immediately after the transplant procedure in order to improve long-term results for both patient and transplant. Among the better known antidiabetics, metformin and DPP-4 inhibitors have a particularly benign profile in the PLTDM context and are the preferred oral agents for long-term management. Insulin therapy is also an effective approach that addresses the prevailing pathophysiological defect of the disorder. There is still insufficient evidence about the impact of newer families of antidiabetics (GLP-1 agonists, SGLT-2 inhibitors) on PLTDM. In this review, we summarize current knowledge on the epidemiology, pathogenesis, course of disease and medical management of PLTDM.

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Section: Management Of Pltdmmentioning

confidence: 99%

Post-Liver Transplantation Diabetes Mellitus: A Review of Relevance and Approach to Treatment

et al. 2018

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“…Several factors such as new-onset diabetes, underlying causes of liver failure and nephrotoxicity of immunosuppressants may contribute to renal dysfunction in liver transplant recipients 19 20 21 . There are some studies showed that BKV prevalence plays roles in renal dysfunction in many solid organ transplants with documented cases of BKV nephropathy after receiving heart, lung, and pancreas transplantation.…”

mentioning

confidence: 99%

The association between polyomavirus BK strains and BKV viruria in liver transplant recipients

Wang

Lee

et al. 2016

Sci Rep

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BK virus (BKV) is a polyomavirus that cause of allograft dysfunction among kidney transplant recipients. The role of BKV infection in non-renal solid organ transplant recipients is not well understood neither for the relationship between various BKV strains with occurrence of BKV viral viruria. This study aimed to understand the prevalence of BKV infection and identified of BKV various strains in the urine of liver transplant recipients. There was not significant difference of renal outcome between high BKV viruria and low BKV viruria in the liver transplant recipients. The WW-non-coding control region (NCCR) BKV detected in urine was associated with higher urinary BKV load, whereas the Dunlop-NCCR BKV was detected in the urine of low urinary BKV load. An in vitro cultivation system demonstrated that WW-BKV strain exhibiting the higher viral DNA replication efficiency and higher BKV load. Altogether, this is the first study to demonstrate the impact of BKV strains on the occurrence of BK viruria in the liver transplant recipients.

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Cardiovascular Screening and Management Among Kidney Transplant Candidates in Hungary

Szabó

Вaргa

Balla

et al. 2015

Transplantation Proceedings

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New-Onset Diabetes Mellitus and the Analysis of Dipeptidyl-Peptidase-4 After Liver Transplantation

Cited by 9 publications

References 12 publications

Post-Liver Transplantation Diabetes Mellitus: A Review of Relevance and Approach to Treatment

Post-Liver Transplantation Diabetes Mellitus: A Review of Relevance and Approach to Treatment

The association between polyomavirus BK strains and BKV viruria in liver transplant recipients

Cardiovascular Screening and Management Among Kidney Transplant Candidates in Hungary

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