1969
DOI: 10.1016/s0021-9258(18)83453-6
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New Observations on the Substrate Specificity of Cathepsin C (Dipeptidyl Aminopeptidase I)

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Cited by 219 publications
(19 citation statements)
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“…Antibodies against cathepsin C were provided by E Mainferme and prepared as described previously (33). Briefly, rabbits were immunized with cathepsin C purified from rat liver according to the method of McDonald et al (34). The IgG fraction was subsequently used and specifically immunoprecipitated multiple forms of the enzymes (see reference 33 for a detailed description of the antigen).…”
Section: Antibodiesmentioning
confidence: 99%
“…Antibodies against cathepsin C were provided by E Mainferme and prepared as described previously (33). Briefly, rabbits were immunized with cathepsin C purified from rat liver according to the method of McDonald et al (34). The IgG fraction was subsequently used and specifically immunoprecipitated multiple forms of the enzymes (see reference 33 for a detailed description of the antigen).…”
Section: Antibodiesmentioning
confidence: 99%
“…The anion binding site is a lysyl residue which apparently has a counterpart in ACE (Lifschitz & Levitzki, 1976;Bünning et al, 1978;Bünning & Riordan, 1981b). Cathepsin C belongs to a second group of anionactivated enzymes (McDonald et al, 1966(McDonald et al, , 1969Gorter & Gruber, 1970) where anions solely affect Ku. Whether anions activate by affecting kQil or KM, in all cases studied the activation is accompanied by a shift of the pH-activity profile toward the alkaline pH region.…”
Section: Easmentioning
confidence: 99%
“…The comparison of the substrate specificity of the porcine brain DAP and the four previously described DAPs is another important discriminating feature. DAP I (Me Donald et al, 1969b) and DAP III (Lee et al, 1982) both hydrolyze angiotensin II whereas the porcine brain DAP does not degrade this peptide. DAP II is inhibited by cations such as Na+, K+, and Tris (Me Donald et al, 1968), and its substrate specificity is restricted to tripeptides.…”
Section: Discussionmentioning
confidence: 99%