New monoclonal antibodies directed against mouse follicular dendritic cells.

Imazeki, Nobuo; Takeuchi, Akiteru; Senoo, Akira; Fuse, Yusuke

doi:10.1177/42.3.8308249

Cited by 8 publications

(7 citation statements)

References 1 publication

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“…While several ontogenetical observations with immunohistochemical procedures regarding the phenotypic evolution of FDC have been recently reported in murine systems (Imaseki et al 1994;Balogh et al 2001;Hoshi et al 2001;Maeda et al 2001), similar observations have not yet been published for the human system except for one study (Muretto 1995). In this report, the author described that a few CD21 + or CD35 + dendritic cells with thin long processes enveloping interposed lymphocytes (probably FDC) initially emerged within the aggregation of B-cells in the cortical area of superficial lymph nodes of the newborns, and inferred that they may have derived from endothelial cells because they frequently appeared in continuity with CD34 + endothelial cells.…”

Section: Introductionmentioning

confidence: 79%

Development, maturation and subsequent activation of follicular dendritic cells (FDC): immunohistochemical observation of human fetal and adult lymph nodes

Kasajima-Akatsuka

Maeda

2006

Histochem Cell Biol

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To elucidate the processes involved in development and activation of human follicular dendritic cells (FDC), immunohistochemistry was performed on paraffin sections of fetal lymph nodes (FLN) obtained from archived autopsy material, and of adult reactive lymph nodes (ARLNs) excised for diagnostic purpose, using a panel of antibodies. Our study showed that tiny clusters of CNA.42(+ )KiM4p(+) cells, surrounded by some B-lymphocytes, initially arose in the cortical area of underdeveloped FLN around the 20th gestational week. No co-expression of CD21 and CD35 was found. In the relatively developed FLN of the same gestational age, small eddies of immature FDC, which expressed CD21, CD35, and nerve growth factor receptor (NGFR), as well as CNA.42 and KiM4p, were observed within ill-defined aggregations of B-lymphocytes. As gestation progressed, more B-lymphocytes assembled in a compact manner and formed primary lymphoid follicles containing an extending web of mature FDC, which expressed CNA.42, KiM4p, CD21, CD35, NGFR, and sometimes CD23 and X-11. In well-developed secondary follicles of ARLNs, activated FDC expressed additional molecules such as CD55, CD106, and S100alpha. Our observations identified the processes of phenotypic alteration of human FDC and established practical indicators determining their developmental stage and functional phase.

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Section: Introductionmentioning

confidence: 79%

Development, maturation and subsequent activation of follicular dendritic cells (FDC): immunohistochemical observation of human fetal and adult lymph nodes

Kasajima-Akatsuka

Maeda

2006

Histochem Cell Biol

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“…The time required for completion of immune maturation differs widely among mammalian species. In mice, where postnatal immune maturation only requires ϳ6 -8 wk, FDC first appear as immune complex-retaining cells at 2 wk (16,58) and GC are absent from spleen and nodes until 3-4 wk of age (Ref. 59 and this report).…”

Section: Discussionmentioning

confidence: 99%

Unresponsiveness to Lymphoid-Mediated Signals at the Neonatal Follicular Dendritic Cell Precursor Level Contributes to Delayed Germinal Center Induction and Limitations of Neonatal Antibody Responses to T-Dependent Antigens

Pihlgren

Tougne

Bozzotti

et al. 2003

The Journal of Immunology

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The factors limiting neonatal and infant IgG Ab responses to T-dependent Ags are only partly known. In this study, we assess how these B cell responses are influenced by the postnatal development of the spleen and lymph node microarchitecture. When BALB/c mice were immunized with alum-adsorbed tetanus toxoid at various stages of their immune development, a major functional maturation step for induction of serum IgG, Ab-secreting cells, and germinal center (GC) responses was identified between the second and the third week of life. This correlated with the development of the follicular dendritic cell (FDC) network, as mature FDC clusters only appeared at 2 wk of age. Adoptive transfer of neonatal splenocytes into adult SCID mice rapidly induced B cell follicles and FDC precursor differentiation into mature FDC, indicating effective recruitment and signaling capacity of neonatal B cells. In contrast, adoptive transfer of adult splenocytes into neonatal SCID mice induced primary B cell follicles without any differentiation of mature FDC and failed to correct limitations of tetanus toxoid-induced GC. Thus, unresponsiveness to lymphoid-mediated signals at the level of neonatal FDC precursors delays FDC maturation and GC induction, thus limiting primary Ab-secreting cell responses to T-dependent Ags in early postnatal life.

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“…These include FcgRs, which confer the ability to bind immune complexes even in the absence of complement (47,53,62), CD23, a low affinity IgE receptor ( Fig. 4) (63, 64) and the molecules recognized by mAbs SKY01 and SKY49 (65). Light zone FDCs also appear to stain more intensely for many of the shared markers, including BP3 and CR1/2 (Fig.…”

Section: Follicular Dendritic Cells Of Primary and Secondary Folliclesmentioning

confidence: 99%

“…In mice and rats, development of immune complex-capturing activity by stromal cells in lymphoid organs occurs between 2 and 3 weeks after birth (46,60,65,66). This event depends critically on the presence of B cells but not T cells (67)(68)(69).…”

Section: Fdc Developmentmentioning

confidence: 99%

Follicular stromal cells and lymphocyte homing to follicles

2000

Immunological Reviews

365

122

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Follicular dendritic cells (FDCs), the best defined stromal cell subset within lymphoid follicles, play a critical role in presenting intact antigen to B lymphocytes. The discovery that many follicular stromal cells make B-lymphocyte chemoattractant (BLC), a CXC chemokine that attracts CXCR5+ cells, provides a basis for understanding how motile B cells come into contact with stationary FDCs. Here we review our work on BLC and discuss properties of BLC-expressing follicular stromal cells. We also review the properties of primary follicle and germinal center FDCs and suggest a model of FDC development that incorporates information about BLC expression. Finally, we consider how antigen recognition causes T and B lymphocytes to undergo changes in chemokine responsiveness that may help direct their movements into, or out of, lymphoid follicles.

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New monoclonal antibodies directed against mouse follicular dendritic cells.

Abstract: Thc follicrrht dendritic adls (PDC) t l w e & & b i n h . T h e P t h a t~~a s i

Cited by 8 publications

References 1 publication

Development, maturation and subsequent activation of follicular dendritic cells (FDC): immunohistochemical observation of human fetal and adult lymph nodes

Development, maturation and subsequent activation of follicular dendritic cells (FDC): immunohistochemical observation of human fetal and adult lymph nodes

Unresponsiveness to Lymphoid-Mediated Signals at the Neonatal Follicular Dendritic Cell Precursor Level Contributes to Delayed Germinal Center Induction and Limitations of Neonatal Antibody Responses to T-Dependent Antigens

Follicular stromal cells and lymphocyte homing to follicles

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