Follicular stromal cells and lymphocyte homing to follicles

doi:10.1034/j.1600-065x.2000.00618.x

Cited by 367 publications

(129 citation statements)

References 95 publications

Supporting

Mentioning

123

Contrasting

Unclassified

Order By: Relevance

“…The factors determining the distribution of CCL21 are not clear, but it seems likely that the chemokine is distributed along stromal cells that are present throughout the follicle [36]. Previous studies have shown that T-zone CCL21 is concentrated on the stromal cell surface [23,37].…”

Section: Discussionmentioning

confidence: 99%

“…Contrary to our observations, a recent study using confocal laser scanning microscopy to image interactions between naive DO11.10 T cells and peptide-loaded B cells concluded that B cells were being pushed by actively migrating T cells [47]. However, most of those data were obtained by imaging cells in a collagen matrix, and although this system provides information on the spectrum of B-T interactions that are possible, these conditions differ substantially from the environment within a lymph node, in which much of the collagen is sheathed by stromal cells (reviewed in [36]). Moreover, no BCR stimulus was included in the experiments performed by Gunzer et al [47], and this could also explain the differences in our observations.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Antigen-Engaged B Cells Undergo Chemotaxis toward the T Zone and Form Motile Conjugates with Helper T Cells

et al. 2005

View full text Add to dashboard Cite

Interactions between B and T cells are essential for most antibody responses, but the dynamics of these interactions are poorly understood. By two-photon microscopy of intact lymph nodes, we show that upon exposure to antigen, B cells migrate with directional preference toward the B-zone–T-zone boundary in a CCR7-dependent manner, through a region that exhibits a CCR7-ligand gradient. Initially the B cells show reduced motility, but after 1 d, motility is increased to approximately 9 μm/min. Antigen-engaged B cells pair with antigen-specific helper T cells for 10 to more than 60 min, whereas non-antigen-specific interactions last less than 10 min. B cell–T cell conjugates are highly dynamic and migrate extensively, being led by B cells. B cells occasionally contact more than one T cell, whereas T cells are strictly monogamous in their interactions. These findings provide evidence of lymphocyte chemotaxis in vivo, and they begin to define the spatiotemporal cellular dynamics associated with T cell–dependent antibody responses.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Antigen-Engaged B Cells Undergo Chemotaxis toward the T Zone and Form Motile Conjugates with Helper T Cells

et al. 2005

View full text Add to dashboard Cite

show abstract

“…It is well established that chemokines and chemokine receptors play an essential role in the homing of lymphocytes. Homing of B cells to the lymphoid follicles in the spleen is regulated by the chemokine CXCL13, and mice lacking CXCL13 or its receptor CXCR5 fail to generate lymphoid follicles (17, 48). CXCL13 is constitutively expressed by cells in both the peritoneal and pleural cavities, including macrophages, and mice lacking CXCL13 have a severe deficiency of B cells in the peritoneal and pleural cavities (48).…”

Section: Discussionmentioning

confidence: 99%

“…The presence of such potentially auto-reactive B cells dictates the requirement for tightly regulated mechanisms to control their activation. Increasing evidences suggests that loss of cellular lipid homeostasis plays an essential role in regulating lymphocyte and hematopoietic cell proliferation, lymphocyte movement within the follicular regions of the spleen and immune responses (12–17). …”

Section: Introductionmentioning

confidence: 99%

ABCG1 Is Required for Pulmonary B-1 B Cell and Natural Antibody Homeostasis

Baldán

Gonen

Choung

et al. 2014

The Journal of Immunology

View full text Add to dashboard Cite

Many metabolic diseases, including atherosclerosis, type 2 diabetes, pulmonary alveolar proteinosis (PAP), and obesity, have a chronic inflammatory component involving both innate and adaptive immunity. Mice lacking the ATP binding cassette (ABC) transporter ABCG1 develop chronic inflammation in the lungs, associated with lipid accumulation (cholesterol, cholesterol ester, and phospholipid) and cholesterol crystal deposition, characteristic of atherosclerotic lesions and PAP. Here we demonstrate that specific lipids, likely oxidized (Ox) phospholipids and/or sterols, elicit a lung-specific immune response in Abcg1−/− mice. Loss of ABCG1 results in increased levels of specific oxysterols, phosphatidylcholines and oxidized phospholipids, including 1-palmitoyl-2-(5’-oxovaleroyl)-sn-glycero-3-phosphocholine (POVPC), in the lungs. Further, we identify a niche-specific increase in natural antibody (NAb)-secreting B-1 B cells in response to this lipid accumulation that is paralleled by increased titers of IgM, IgA and IgG against oxidation specific epitopes such as those on OxLDL and malondialdehyde-modified LDL (MDA-LDL). Finally we identify a cytokine/chemokine signature reflective of increased B cell activation, antibody secretion and homing. Collectively, these data demonstrate that the accumulation of lipids in Abcg1−/− mice induces the specific expansion and localization of B-1 B cells, which secrete NAbs that may help protect against the development of atherosclerosis. Indeed, despite chronic lipid accumulation and inflammation, hyperlipidemic mice lacking ABCG1 develop smaller atherosclerotic lesions compared to controls. These data also suggest that Abcg1−/− mice may represent a new model in which to study the protective functions of B-1 B cells/NAbs, and suggest novel targets for pharmacologic intervention and treatment of disease.

show abstract

“…In addition to their role in retention of antigen, FDC are a major source of the B cell chemoattractant CXCL-13 which is required for migration of B cells into the follicles (Cyster et al, 2000). FDC differentiate from ubiquitous perivascular precursors (preFDC) that have been recently identified in an elegant report by Aguzzi and colleagues (Krautler et al, 2012).…”

Section: Fdc Maintain Germinal Centersmentioning

confidence: 99%

Regulation of Humoral Immunity by Complement

2012

View full text Add to dashboard Cite

Summary The complement system of innate immunity plays an important role in regulating humoral immunity in large part through the complement receptor CR2 which forms a co-receptor on B cells during antigen-induced activation and retains antigens on follicular dendritic cells, which are critical for maintenance of germinal centers. Recent studies, identify a third important pathway in which naïve B cells pick-up complement C3-coated immune complexes within the lymphatics via CR2 and deliver them to follicular dendritic cells in the B cell compartment. These findings, combined with the recent report on the co-crystal structure of CR2 and its ligand C3d, present additional opportunities for dissecting a possible role for this pathway in regulating autoimmune responses.

show abstract

Follicular stromal cells and lymphocyte homing to follicles

Cited by 367 publications

References 95 publications

Antigen-Engaged B Cells Undergo Chemotaxis toward the T Zone and Form Motile Conjugates with Helper T Cells

Antigen-Engaged B Cells Undergo Chemotaxis toward the T Zone and Form Motile Conjugates with Helper T Cells

ABCG1 Is Required for Pulmonary B-1 B Cell and Natural Antibody Homeostasis

Regulation of Humoral Immunity by Complement

Contact Info

Product

Resources

About