New model for adenine-induced chronic renal failure in mice, and the effect of gum acacia treatment thereon: Comparison with rats

Ali, Badreldin H.; Al-Salam, Suhail; Za’abi, Mohammed Al; Waly, Mostafa I.; Ramkumar, Aishwarya; Beegam, Sumyia; Al-Lawati, Intisar; Adham, Sirin A.; Nemmar, Abderrahim

doi:10.1016/j.vascn.2013.05.001

Cited by 91 publications

(93 citation statements)

References 32 publications

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“…Previous studies on adenine-induced renal changes have been qualitative in nature [5]. In this paper, we provide innovative quantitative data that supports above previous observations.…”

Section: Discussionsupporting

confidence: 85%

“…Also, we have recently shown that adenine-treated rats showed by Western blotting a detectable caspase-3 cleavage, which may be considered a possible mechanism involved in the adenine-induced CKD. The induced apoptosis was almost totally suppressed by GA in rat kidney tissue [5]. Recently, it has been reported that the complex inflammatory phenomena associated with adenine -induced CKD at the molecular level, may depend, at least partially, on NF-κB activation [20].…”

Section: Discussionmentioning

confidence: 99%

“…Ali et al [5] have recently demonstrated that gum acacia (GA) treatment was effective in ameliorating several biochemical, physiological and histopathological indices, and motor and behavioral changes in adenine-induced CRF [6]. However, the effect of adenine-induced CKD on cardiac microstructure in rats, and the possible protective effects of GA thereon have not been investigated.…”

Section: Introductionmentioning

confidence: 99%

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Renal and Myocardial Histopathology and Morphometry in Rats with Adenine - Induced Chronic Renal Failure: Influence of Gum Acacia

Ali

Inuwa

Za’abi³

et al. 2014

Cell Physiol Biochem

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Background/Aim: Chronic kidney disease (CKD) is associated with increased occurrence of cardiovascular system dysfunction. Previous studies have revealed a number of alterations in the kidneys and heart during CKD. However, unbiased quantitative studies on these structures in this disease have so far not been addressed. Materials and Methods: We induced CKD in rats by feeding adenine (0.75% ^w/w, four weeks) and using unbiased stereological methods, investigated the effect of the ensuing CKD on the kidneys and left ventricular structure. Since gum acacia (GA) has previously been shown to ameliorate the severity of CKD in humans and rodents, we investigated the effect of giving GA (15% ^w/v in the drinking water concomitantly with adenine) on the kidneys and left ventricular structure using the above model. Results: The CKD was confirmed by standard biochemical indices in plasma and urine and by accumulation of the uremic toxin indoxyl sulfate. Additionally, it increased blood pressure. In rats with CKD absolute volume of left ventricle was significantly increased, and the volume density and absolute volume of myocardial capillaries were decreased, whilst the same parameters of myocardium and interstitial tissue were increased. Renal morphometry demonstrated significant increase in kidney volume and interstitial tissue in adenine- treated rats. Similarly, glomerular Bowman's capsule was significantly thickened. The myocardial and renal changes were significantly mitigated by GA treatment. Conclusions: These results add to our existing knowledge of the pathophysiology of adenine - CKD and provides plausible histopathological and morphometric evidence for the usefulness of GA in CKD.

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“…Previous studies on adenine-induced renal changes have been qualitative in nature [5]. In this paper, we provide innovative quantitative data that supports above previous observations.…”

Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Renal and Myocardial Histopathology and Morphometry in Rats with Adenine - Induced Chronic Renal Failure: Influence of Gum Acacia

Ali

Inuwa

Za’abi³

et al. 2014

Cell Physiol Biochem

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“…Various animal models, including surgically and diet-induced and/or genetic manipulation, are used to study CKD [3,8,9,10]. Nevertheless, the most commonly used is a rat model with progressive renal failure model, also named as the ‘remnant kidney' or 5/6 nephrectomy [11,12]. It is worth noting that this classical model of subtotal nephrectomy closely mimics human CKD, and for this reason, several experimental and novel therapies have been developed using this model [11,13].…”

Section: Introductionmentioning

confidence: 99%

“…Nevertheless, the most commonly used is a rat model with progressive renal failure model, also named as the ‘remnant kidney' or 5/6 nephrectomy [11,12]. It is worth noting that this classical model of subtotal nephrectomy closely mimics human CKD, and for this reason, several experimental and novel therapies have been developed using this model [11,13]. A subtotal nephrectomy model leads to alterations in the bone quantity and quality, which can be evaluated using a variety of diagnostic techniques.…”

Section: Introductionmentioning

confidence: 99%

The Biomechanical Testing for the Assessment of Bone Quality in an Experimental Model of Chronic Kidney Disease

Oksztulska-Kolanek¹,

Znorko²,

Michałowska

et al. 2015

Nephron

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Mineral metabolism disturbances are common in chronic kidney disease (CKD) and have been classified as a new clinical entity, also known as CKD-mineral and bone disorders (CKD-MBD). A decrease in the bone strength, whose clinical manifestation is a tendency for fracture, has been recognized as an important component of CKD-MBD. Because of ethical issues, measurements of the bone strength in the human body are usually limited to noninvasive techniques, such as radiography, dual-energy X-ray absorptiometry and the assays of bone turnover biomarkers. However, it has been postulated recently that the evidence concerning bone strength based solely on the determination of the bone quantity may be insufficient and that bone quality should also be examined. In this regard, an animal model of CKD can represent an experimental tool to test the effectiveness of new therapeutic strategies. Despite the many available methods that are used to diagnose metabolic bone disorders and predict fracture risk especially in small rodents with CKD, it turns out that the most appropriate are biomechanical tests, which can provide information about the structural and material properties of bone. The present review summarizes and discusses the principles for carrying out selected biomechanical tests (3-point bending test and compression test) and their application in clinical practice.

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Acacia nilotica (L.) Delile. (Fabaceae/Leguminosae)

Akbar

2020

Handbook of 200 Medicinal Plants

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New model for adenine-induced chronic renal failure in mice, and the effect of gum acacia treatment thereon: Comparison with rats

Cited by 91 publications

References 32 publications

Renal and Myocardial Histopathology and Morphometry in Rats with Adenine - Induced Chronic Renal Failure: Influence of Gum Acacia

Renal and Myocardial Histopathology and Morphometry in Rats with Adenine - Induced Chronic Renal Failure: Influence of Gum Acacia

The Biomechanical Testing for the Assessment of Bone Quality in an Experimental Model of Chronic Kidney Disease

Acacia nilotica (L.) Delile. (Fabaceae/Leguminosae)

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