New Methods of Assessment of Subclinical Changes in the Cardiovascular System in Arterial Hypertension

Kobalava, Zh. D.; Kotovskaya, Yu. V.; Bogomaz, Anna

doi:10.20996/1819-6446-2016-12-3-317-324

Cited by 6 publications

(2 citation statements)

References 40 publications

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“…The difference in pressure in the aorta and at the periphery is associated with the phenomenon of amplification: the result of an early merger of the reflected wave with the systolic component of the direct wave due to the proximity of the reflection points. This phenomenon does not allow estimation of the true pressure in the aorta through the measurement of peripheral BP [36]. These changes increase afterload in the left ventricle, resulting in myocardial hypertrophy, increased oxygen consumption, decreased systolic volume and CO, impaired diastolic function, and heart failure (HF).…”

Section: Features Of Target Organ Damages In Young People With Hypert...mentioning

confidence: 99%

Arterial hypertension in young adults

Bazdyreva

Shavarova

Ezhova

et al. 2023

Vestn. Ross. univ. družby nar., Ser. Med.

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Arterial hypertension (AH) is associated with the development of pathological changes in target organs, which leads to an increase in morbidity and mortality. The aim of the review was to discuss the peculiarity of AH in young people, in particular risk factors for developing AH, associations between the risk of cardiovascular events and elevated blood pressure in young adults, blood pressure phenotypes in young people, the role of traditional cardiovascular diseases risk factors in young people with AH, features of target organ damages in young people with AH and optimal blood pressure for target organ protection. Threshold values of blood pressure, from which the cycle of pathological changes starts, have not been finally determined, however, it is likely that they are significantly lower than the blood pressure values that are currently used to diagnose AH n in Europe and Russia. Reclassification of AH using more strict criteria in the United States resulted in an increase in the prevalence of AH from 29 % to 43 %, and affected mainly young people. Obesity, increased daily sodium excretion, increased consumption of meat products, dyslipidemia, hyperinsulinemia, hyperuricemia, high levels of depression and low social status are among the potential risk factors for developing AH at a young age, while a low-salt diet, eating a large amount of plant foods, high in carotenoids and folate, and a high level of physical activity may have a preventive effect on the development of AH. The results of recent studies indicate a high prevalence of AH, including masked, in young people, which often remains underestimated in real clinical practice. The strategy for the treatment of AH in young patients has not been determined, which is associated with an insufficient evidence base. Studies are needed to identify additional arguments for initiating or withholding antihypertensive therapy in this population, including the study of early signs of hypertension-associated target organ damage. Conclusion. The results of recent studies indicate a high prevalence of hypertension, including masked, in young people, which often remains underestimated in real clinical practice. Further research is required to identify additional arguments for initiating or withholding antihypertensive therapy in this population, including the study of early signs of hypertension-associated target organ damage.

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Section: Features Of Target Organ Damages In Young People With Hypert...mentioning

confidence: 99%

Arterial hypertension in young adults

Bazdyreva

Shavarova

Ezhova

et al. 2023

Vestn. Ross. univ. družby nar., Ser. Med.

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“…данной модели исследователи оценивают ЛЖАВ у здоровых людей, у пожилых, при сердечной недостаточности, заболеваниях клапанов сердца, ИБС, артериальной гипертонии и сахарном диабете [15][16][17][18]. Тем не менее, исследования ЛЖАВ при сочетании ИКМП с ХОБЛ в доступной литературе не представлены.…”

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Influence of concomitant chronic obstructive pulmonary disease on left ventricular-arterial interaction in patients with ischemic cardiomyopathy

Мясоедова¹,

Шварц²,

Полунина³

et al. 2019

Russ J Cardiol

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Aim. To assess the influence of concomitant chronic obstructive pulmonary disease (COPD) on the parameters of left ventricular-arterial interaction in patients with ischemic cardiomyopathy (ICMP).Material and methods. We examined 130 patients with ICMP and 42 patients with ICMP and COPD. All patients underwent transthoracic echocardiography using the MyLab 70 (Italy) according standard method, followed by calculation of the left ventricular-arterial interaction and left ventricular (LV) energy. Statistical data processing was performed using the program “Statistica 12.0” (Stat Soft, Inc., USA).Results. We found that patients with isolated ICMP and in combination with COPD often have a functional imbalance between the activity of LV and arterial system, as evidenced by an increase in the left ventricular-arterial interaction ratio. The increase in the left ventricular-arterial interaction ratio is due to an insufficient increase in left ventricular stiffness, but not a change in the elastic properties of the arterial system. This is indicated by a pronounced decrease in left ventricular elasticity against the background of the relative constancy of arterial elasticity. At the same time, in patients with ICMP and COPD we detected significantly more severe impairment in the parameters of left ventricular-arterial interaction and LV energy than in isolated pathology.Conclusion. The presence of COPD in patients with ICMP allows us to consider it as a significant negatively modifying factor that has a negative impact on the functionality of LV and parameters of left ventricular-arterial interaction.

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