New metal complexes of sulfonamide: Synthesis, characterization, in‐vitro anticancer, anticholinesterase, antioxidant, and antibacterial studies

Abstract

In this research work a sulfonamide from tranexamic acid has been synthesized followed by its metal complexation. p-Bromo benzene sulfonyl chloride was used to synthesize sulfonamide using eco-friendly atmosphere. The sulfonamide prepared from tranexamic acid has been utilized for the preparation of metal complexes with various metals like Ni, Cu, Co, Mn, Pb, Cd, Cr, Fe, Sn, and Sr. All synthesized compounds were characterized by applying different spectral techniques such as Fourier-transform infrared (FTIR), mass spectrometry, and X-ray diffraction (XRD) analysis. The biological activities such as radical scavenging activity, enzyme inhibition, antifungal, antibacterial, and anticancer were performed. It was concluded from the results that compounds showed moderate to good activity. Cu complex of sulfonamide showed the highest antioxidant potential (87.69 ± 1.8% with IC 50 137 ± 1.0 μg) while Cr complex depicted the highest activity against both enzymes; AChE (73.51 ± 1.7% with IC 50 165 ± 1.1 μg) and BChE (70.05 ± 1.3% with IC 50 152 ± 1.8 μg). Mn complex showed good results against six bacterial strains comparable with standard drug. Cr complex depicted highest anticancer activity against MCF7 and human corneal epithelial cell (HCEC) cell lines 45.73% and 25.40%, respectively. These results concluded that metal complexes of sulfonamide may be good induction in the future for medical purposes.

Synthesis, characterization, DNA binding, and biological action of dimedone arylhydrazone chelates

“…Transition metal complexes of sulfonamides and hydrazides, meanwhile, offer a wide range of applications in chemotherapy. [ 19 ]…”

“…Transition metal complexes of sulfonamides and hydrazides, meanwhile, offer a wide range of applications in chemotherapy. [19] In this paper, we keep track of the construction and clarification of 2-(4-sulfadiazine)hydrazono dimedone (HL) and its Co 2+ , Ni 2+ , and Cu 2+ chelates (1-3) utilizing several spectrophotometric methods. Bond angles, bond lengths, and parameters of quantum chemical have all been tuned in the chelates.…”

A Comprehensive Approach to Derivatization: Elemental Composition, Biochemical, and In Silico Studies of Metformin Derivatives Containing Copper and Zinc Complexes

“…The strongest correlation with diabetes and cancer has been observed in breast, pancreas, and endometrial tumors [ 16 ]. Copper complexes of metformin have been synthesized, showing great levels of antidiabetic and antioxidant defense effects [ 17 , 18 ]. Various metals such as copper and zinc have been used to form metal complexes with metformin [ 19 , 20 ].…”

Synthesis, spectroscopic, in vitro, in silico, and in vivo studies of binuclear Cu (II), Ni (II), Ru (II), and Zn (II) complexes with tetradentate Schiff base ligand

“…The antioxidant and antimicrobial activities of the ligand and metal complexes are also investigated. [ 15–17 ]…”

“…The antioxidant and antimicrobial activities of the ligand and metal complexes are also investigated. [15][16][17] 2 | EXPERIMENTAL Chemicals and reagents, instrumentation details, and experimental techniques for biological studies are provided in the supporting information. S C H E M E 1 Synthesis of Schiff base ligand 2.1.2 | Synthesis of metal complexes About 2:1 proportion of the ethanolic solution of the hydrated metal salts and the imine base ligand was stirred and then refluxed for 13 h to get a colored precipitate which was collected by filtration, washed with cold ethanol (Scheme 2).…”