New metal based drugs: Spectral, electrochemical, DNA-binding, surface morphology and anticancer activity properties

Çeşme, Mustafa; Gölcü, Ayşegül; Demirtaş, İbrahim

doi:10.1016/j.saa.2014.06.144

Cited by 34 publications

(11 citation statements)

References 52 publications

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“…Hence it has attracted a great attention in medicine field [10] and many studies have been carried out on Zn(II) complex and its biological properties such as antimicrobial [11] and antitumor [12], [13], [14] activity. Some studies reported the bigger DNA binding constant for Zn in comparison to the other metals such as Cu and Ni [15].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization, crystal structure, DNA- and HSA-binding studies of a dinuclear Schiff base Zn(II) complex derived from 2-hydroxynaphtaldehyde and 2-picolylamine

Kazemi

Rudbari

Mirkhani

et al. 2015

Journal of Molecular Structure

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Section: Introductionmentioning

confidence: 99%

Synthesis, characterization, crystal structure, DNA- and HSA-binding studies of a dinuclear Schiff base Zn(II) complex derived from 2-hydroxynaphtaldehyde and 2-picolylamine

Kazemi

Rudbari

Mirkhani

et al. 2015

Journal of Molecular Structure

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“…Synergistic action and structural modification due to the encapsulation of metal ions between ligand drug molecules cast a huge difference in overall drug efficacy. In order to advance further in this direction, the study was designed to biologically analyze the Zn‐Complex and Mn‐Complex and evaluate wholly for detailed therapeutic potential [43,78–81] . The stability of the complexes was evinced by treating them under acidic pH (more precisely, pH 1).…”

Section: Resultsmentioning

confidence: 99%

“…In order to advance further in this direction, the study was designed to biologically analyze the Zn-Complex and Mn-Complex and evaluate wholly for detailed therapeutic potential. [43,[78][79][80][81] The stability of the complexes was evinced by treating them under acidic pH (more precisely, pH 1). The peaks were shifted to the shorter wavelength.…”

Section: Discussionmentioning

confidence: 99%

Comprehensive Biological, Photodegradation, Density Functional Theory, and Docking Exploration of Zn(II) and Mn(II) complexes of Piroxicam

Maha,

Tajammal,

Samra

et al. 2023

ChemistrySelect

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The biological evaluation of coordination complexes is an active research area ascribed to structural modification and synergistic action due to metal ions. The mononuclear complexes of Zn(II) and Mn(II) piroxicam were evaluated for their encyclopedic biological activities, DFT, and docking exploration. Different antioxidant methods were used to assess their antioxidant potential. DNA cleavage and protein binding properties of the complexes were monitored through gel electrophoresis and UV‐visible spectrophotometry. The low IC50 value of both complexes implies more potency than the piroxicam. The percent cleavage and binding constant values indicated that the complexes bind with DNA and BSA more efficiently than the piroxicam. In SD rats, complexes were screened for analgesic, anti‐anxiety, anti‐inflammatory, and anti‐hyperglycemic effects. The complexes demonstrated statistically significant results for in‐vivo analysis. Photodegradation results of the metal complexes under UV lamp exhibited abrupt degradation than the piroxicam. Docking results also validate a better propensity of both complexes to bind with DNA and BSA. Hydrogen bonding and Van der Waals forces play a key role in stabilizing complexes in DNA and BSA binding pockets. These metal complexes have evident therapeutic potential more than piroxicam and could be promising drugs for relieving pain, anxiety, inflammation, and associated comorbidities with good pharmacodynamic properties.

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“…8 The interaction of DNA with metal complexes has been well studied and has led to the development of new metal-based drugs and DNA cleavage agents. 9 Several metal ions play a vital role in human physiological and biological processes by controlling and stabilizing the cellular events 10,11 and also act as cofactors in protein functions. To facilitate the role of metal ions during various cellular events, a highly sensitive and selective inbuilt system has been developed by the human body for their proper route and specific target.…”

Section: Introductionmentioning

confidence: 99%

Varying structural motifs in the salen based metal complexes of Co(ii), Ni(ii) and Cu(ii): synthesis, crystal structures, molecular dynamics and biological activities

et al. 2016

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Herein, we report the structural and biological activities of a deprotonated Schiff base ligand (HL) {HL = 1,1'-(1E,1'E)-(2,4,6-trimethyl-1,3-phenylene)bis(azan-1-yl-1-ylidene)bis(methan-1-yl-1-ylidene)dinaphthalen-2-ol} towards Co(ii), Ni(ii) and Cu(ii) complexes obtained under different conditions. Four new metal complexes have been synthesized: isostructural dimers [Co(L)] (1)/[Cu(L)] (3), a monomer (ClNiHL)·(EtNH) (2) and a tetramer [Cu(L)] (4). The bioactivity of 1-3 has been investigated through molecular docking with DNA and various proteins, known to be involved in the proliferation of viral diseases or progression of cancer. Complex 1 shows the best results, through a strong binding affinity with NS2B/NS3 protease (dengue virus) in terms of binding energy (-11.21 kcal mol) and inhibition constant (6.02 nM). The experimental evidence for the effective binding of 1-4 with the Bovine Serum Albumin (BSA) protein and calf thymus DNA (CT-DNA) is in agreement with our molecular docking results. In addition, the cytotoxicity and antibacterial activity of 1-4 were examined and found to be compatible with biological systems, with 4 showing the highest antibacterial activity. All four complexes were analyzed by elemental analysis and UV/vis analysis, and their molecular structures were authenticated by single crystal X-ray studies.

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New metal based drugs: Spectral, electrochemical, DNA-binding, surface morphology and anticancer activity properties

Cited by 34 publications

References 52 publications

Synthesis, characterization, crystal structure, DNA- and HSA-binding studies of a dinuclear Schiff base Zn(II) complex derived from 2-hydroxynaphtaldehyde and 2-picolylamine

Synthesis, characterization, crystal structure, DNA- and HSA-binding studies of a dinuclear Schiff base Zn(II) complex derived from 2-hydroxynaphtaldehyde and 2-picolylamine

Comprehensive Biological, Photodegradation, Density Functional Theory, and Docking Exploration of Zn(II) and Mn(II) complexes of Piroxicam

Varying structural motifs in the salen based metal complexes of Co(ii), Ni(ii) and Cu(ii): synthesis, crystal structures, molecular dynamics and biological activities

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