New merosesquiterpenes from a Vietnamese marine sponge of Spongia sp. and their biological activities

Nguyen, Hien Minh; Ito, Takuya; Kurimoto, Shin-ichiro; Ogawa, Mikako; Win, Nwet Nwet; Hung, Vo Quoc; Nguyen, Hoai Thi; Kubota, Takaaki; Kobayashi, Jun’ichi; Morita, Hiroyuki

doi:10.1016/j.bmcl.2017.05.060

Cited by 21 publications

(22 citation statements)

References 23 publications

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“…Merosesquiterpenoids were isolated from the genera Dactylospongia 1092, 1093, 443 Hyrtios 1094-1097, 444,445 Smenospongia 1098-1103 (ref. 446 and 447) and Spongia 1104-1107, 448 1108-1119. 449 Naturally occurring blue pigments are rare and hence are desirable for the food and beverage industry.…”

Section: Spongesmentioning

confidence: 99%

Marine natural products

et al. 2019

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Section: Spongesmentioning

confidence: 99%

Marine natural products

et al. 2019

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“…On the other hand, compounds 248 and 249 were inactive against K. pneumoniae and E. coli, compared to the positive control Kanamycin ((MIC = 6.25 and 12.5 µM, respectively) [82]. In another investigation, Nguyen et al [83] further isolated sesquiterpene-based meroterpenoids, langconols A-C (250-252) (Figure 27) and langcoquinone C (253) from the same sponge viz., Spongia sp. Furthermore, compounds 250-252 bear the 4,9-friedodrimane skeleton along with phenolic functionality while langcoquinone C (253) has an hydroxyquinone instead of the phenolic group.…”

Section: Sesquiterpene-based Meroterpenoidsmentioning

confidence: 99%

Meroterpenoids: A Comprehensive Update Insight on Structural Diversity and Biology

et al. 2021

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Meroterpenoids are secondary metabolites formed due to mixed biosynthetic pathways which are produced in part from a terpenoid co-substrate. These mixed biosynthetically hybrid compounds are widely produced by bacteria, algae, plants, and animals. Notably amazing chemical diversity is generated among meroterpenoids via a combination of terpenoid scaffolds with polyketides, alkaloids, phenols, and amino acids. This review deals with the isolation, chemical diversity, and biological effects of 452 new meroterpenoids reported from natural sources from January 2016 to December 2020. Most of the meroterpenoids possess antimicrobial, cytotoxic, antioxidant, anti-inflammatory, antiviral, enzyme inhibitory, and immunosupressive effects.

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“…MC025 [48]; two new polyketides engyodontochones A and B (37,38) isolated from the Croatian marine sponge Cacospinga scalaris-derived fungus Engyodontium album LF069 [49]; five new polyhydroxylated hydroanthraquinone derivates (39)(40)(41)(42)(43) isolated from the Chinese marine red alga Laurencia okamurai-derived fungus Talaromyces islandicus EN-501 [50]; a novel sesquiterpene hydroxyquinone langcoquinone C (44) isolated from a Vietnamese marine sponge Spongia sp. [51]; the sesterterpene luffariellolide (45) isolated from the Philippine marine sponge Suberea sp. [52]; three new manzamine alkaloids (46)(47)(48) isolated from an Indonesian marine sponge Acanthostrongylophora sp.…”

Section: Antibacterial Activitymentioning

confidence: 99%

“…Further 2016-2017 preclinical pharmacology for marine compounds (49,51) as well as that of 79 compounds (235-313) with miscellaneous mechanisms of action is shown in Table 3, with their corresponding structures, presented in Figure 3. Given that, at the time of publication, a comprehensive pharmacological characterization of these compounds remained unavailable, their assignment to a particular drug class will probably require further investigation into their molecular mechanism of action.…”

Section: Marine Compounds With Miscellaneous Mechanisms Of Actionmentioning

confidence: 99%

Marine Pharmacology in 2016–2017: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis and Antiviral Activities; Affecting the Immune and Nervous Systems, and Other Miscellaneous Mechanisms of Action

et al. 2021

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The review of the 2016–2017 marine pharmacology literature was prepared in a manner similar as the 10 prior reviews of this series. Preclinical marine pharmacology research during 2016–2017 assessed 313 marine compounds with novel pharmacology reported by a growing number of investigators from 54 countries. The peer-reviewed literature reported antibacterial, antifungal, antiprotozoal, antituberculosis, and antiviral activities for 123 marine natural products, 111 marine compounds with antidiabetic and anti-inflammatory activities as well as affecting the immune and nervous system, while in contrast 79 marine compounds displayed miscellaneous mechanisms of action which upon further investigation may contribute to several pharmacological classes. Therefore, in 2016–2017, the preclinical marine natural product pharmacology pipeline generated both novel pharmacology as well as potentially new lead compounds for the growing clinical marine pharmaceutical pipeline, and thus sustained with its contributions the global research for novel and effective therapeutic strategies for multiple disease categories.

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New merosesquiterpenes from a Vietnamese marine sponge of Spongia sp. and their biological activities

Cited by 21 publications

References 23 publications

Marine natural products

Marine natural products

Meroterpenoids: A Comprehensive Update Insight on Structural Diversity and Biology

Marine Pharmacology in 2016–2017: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis and Antiviral Activities; Affecting the Immune and Nervous Systems, and Other Miscellaneous Mechanisms of Action

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