New membranes based on polyethersulfone – SlipSkin™ polymer blends with low fouling and high blood compatibility

Beek, O. ter; Pavlenko, Denys; Suck, Meina; Helfrich, S.; Bolhuis-Versteeg, Lydia A.M.; Snisarenko, Dmytro; Causserand, Christel; Bacchin, Patrice; Aimar, Pierre; Oerle, René van; Wetzels, Rick; Verhezen, Paul W M; Henskens, Yvonne; Stamatialis, Dimitrios

doi:10.1016/j.seppur.2019.05.049

Cited by 24 publications

(7 citation statements)

References 36 publications

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“…Furthermore, helpful methods to eliminate fouling can be, for example, heat and plasma treatment [ 4 , 34 , 35 , 36 , 37 ], coating or grafting of hydrophilic polymers onto membranes’ surfaces [ 33 , 35 , 38 , 39 , 40 , 41 , 42 , 43 ], or through the addition of hydrophilic pore precursors to a polymer solution or other admixture like nanoparticles [ 6 , 19 , 25 , 44 , 45 , 46 , 47 , 48 ]. The modification could be influenced by an increase of the hydraulic permeability and/or the hydrophilicity of membranes.…”

Section: Introductionmentioning

confidence: 99%

Chemical Degradation of PSF-PUR Blend Hollow Fiber Membranes—Assessment of Changes in Properties and Morphology after Hydrolysis

et al. 2021

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In this study, we focused on obtaining polysulfone-polyurethane (PSF-PUR) blend partly degradable hollow fiber membranes (HFMs) with different compositions while maintaining a constant PSF:PUR = 8:2 weight ratio. It was carried out through hydrolysis, and evaluation of the properties and morphology before and after the hydrolysis process while maintaining a constant cut-off. The obtained membranes were examined for changes in ultrafiltration coefficient (UFC), retention, weight loss, morphology assessment using scanning electron microscopy (SEM) and MeMoExplorer™ Software, as well as using the Fourier-transform infrared spectroscopy (FT-IR) method. The results of the study showed an increase in the UFC value after the hydrolysis process, changes in retention, mass loss, and FT-IR spectra. The evaluation in MeMoExplorer™ Software showed the changes in membranes’ morphology. It was confirmed that polyurethane (PUR) was partially degraded, the percentage of ester bonds has an influence on the degradation process, and PUR can be used as a pore precursor instead of superbly known polymers.

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Section: Introductionmentioning

confidence: 99%

Chemical Degradation of PSF-PUR Blend Hollow Fiber Membranes—Assessment of Changes in Properties and Morphology after Hydrolysis

et al. 2021

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“…We have developed membranes based on blends of PES and SlipSkin, which have very good haemocompatibility (e.g. low cell adhesion and low complement system activation) and provide high removal of uraemic toxins 77 , 78 . SlipSkin is a random copolymer consisting of hydrophilic N-vinylpyrrolidone and hydrophobic N-butylmethacrylate) moieties that does not elute from the membrane within 24 h of filtration 78 .…”

Section: Membranes For Artificial Kidneysmentioning

confidence: 99%

Portable, wearable and implantable artificial kidney systems: needs, opportunities and challenges

Ramada,

de Vries,

Vollenbroek

et al. 2023

Nat Rev Nephrol

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Haemodialysis is life sustaining but expensive, provides limited removal of uraemic solutes, is associated with poor patient quality of life and has a large carbon footprint. Innovative dialysis technologies such as portable, wearable and implantable artificial kidney systems are being developed with the aim of addressing these issues and improving patient care. An important challenge for these technologies is the need for continuous regeneration of a small volume of dialysate. Dialysate recycling systems based on sorbents have great potential for such regeneration. Novel dialysis membranes composed of polymeric or inorganic materials are being developed to improve the removal of a broad range of uraemic toxins, with low levels of membrane fouling compared with currently available synthetic membranes. To achieve more complete therapy and provide important biological functions, these novel membranes could be combined with bioartificial kidneys, which consist of artificial membranes combined with kidney cells. Implementation of these systems will require robust cell sourcing; cell culture facilities annexed to dialysis centres; large-scale, low-cost production; and quality control measures. These challenges are not trivial, and global initiatives involving all relevant stakeholders, including academics, industrialists, medical professionals and patients with kidney disease, are required to achieve important technological breakthroughs.

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“…In 2019, Stamatialis et al 42 proposed a methodology to prepare flat hemodialysis membranes by blending PES with SlipSkin™ (PES-SS). SlipSkin™ (SS) is a random copolymer of hydrophilic N -vinylpyrrolidone (NVP) and hydrophobic N -butyl methacrylate (BMA) in a 50 : 50 ratio.…”

Section: Dialysis Membranes (Artificial Kidney)mentioning

confidence: 99%

The separation membranes in artificial organs

Sheng

Sun

et al. 2023

Mater. Chem. Front.

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New membranes based on polyethersulfone – SlipSkin™ polymer blends with low fouling and high blood compatibility

Cited by 24 publications

References 36 publications

Chemical Degradation of PSF-PUR Blend Hollow Fiber Membranes—Assessment of Changes in Properties and Morphology after Hydrolysis

Chemical Degradation of PSF-PUR Blend Hollow Fiber Membranes—Assessment of Changes in Properties and Morphology after Hydrolysis

Portable, wearable and implantable artificial kidney systems: needs, opportunities and challenges

The separation membranes in artificial organs

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