New medicines and approaches to treatment of atherosclerosis

Borshch, V. N.; Andreeva, E. R.; Kuzmin, Sergey G.; Vozovikov, I. N.

doi:10.1134/s1070363212030346

Cited by 7 publications

(7 citation statements)

References 52 publications

(49 reference statements)

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“…Because they do not interrupt the blood flow, bare radial/cylindrical diffusers can be used for longer durations in small (<1 mm) vessels, but require that the illumination wavelength be chosen in the longer-wavelength part of the visible spectrum (>650 nm) to minimize light absorption by the blood. This also results in a comparatively deeper light penetration into tissues, and limits the possible side effects associated with intimal hyperplasia [13] or thrombosis [27]. Instances are reported [28] when the PDT effect described is too weak, a side effect that can be ascribed to the blood absorption of light [28][29][30].…”

Section: Radiance Measurementsmentioning

confidence: 99%

Optical Characterization of an Intra-Arterial Light and Drug Delivery System for Photodynamic Therapy of Atherosclerotic Plaque

et al. 2020

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Although the versatility of photodynamic therapy (PDT) is well established, the technical aspects of light delivery systems vary significantly depending on the targeted organ. This article describes the optical properties of a light and drug delivery system (catheter and light diffuser) suitable for intra-arterial PDT by using a planar imaging goniometer to measure the full radiance longitudinal and angular profiles at the surface of the diffuser at 652 nm. The results show that the system emits almost Lambertian and “top hat” profiles, an interesting feature to determine the light dosimetry in the many vascular applications of PDT.

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Section: Radiance Measurementsmentioning

confidence: 99%

Optical Characterization of an Intra-Arterial Light and Drug Delivery System for Photodynamic Therapy of Atherosclerotic Plaque

et al. 2020

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“…In addition, such lasers emit light in a narrow spectral domain, thus minimizing illumination duration for a given total light dose. These qualities along with the widespread availability of cheap, reliable easy‐to‐use semiconductor laser diodes explain why they are ubiquitously selected as illumination sources . It should be noted, however, that each photosensitizer requires relatively specific activation wavelength(s).…”

Section: Light Source and Light Diffusersmentioning

confidence: 99%

“…Indeed, pragmatism indicates that the best way to achieve suitable illumination is through endovascular light delivery, using a cylindrical (radial) diffuser such as the one described in Figure or that described by Mizeret et al . In all instances, the goal is to achieve homogenous light delivery without temperature increase in order to maximize the photodynamic effects while avoiding possibly deleterious thermal effects or other side effects . Generally, however, radial/cylindrical diffusers offer an interesting way to deliver intravascular illumination for the treatment of acute coronary syndromes and regional atherosclerosis, especially for plaque stabilization, as opposed to plaque ablation.…”

Section: Light Source and Light Diffusersmentioning

confidence: 99%

Photodynamic therapy for the treatment of atherosclerotic plaque: Lost in translation?

Jain

Zellweger

Wagnières

et al. 2017

Cardiovascular Therapeutics

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Summary Acute coronary syndrome is a life‐threatening condition of utmost clinical importance, which, despite recent progress in the field, is still associated with high morbidity and mortality. Acute coronary syndrome results from a rupture or erosion of vulnerable atherosclerotic plaque with secondary platelet activation and thrombus formation, which leads to partial or complete luminal obstruction of a coronary artery. During the last decade, scientific evidence demonstrated that when an acute coronary event occurs, several nonculprit plaques are in a “vulnerable” state. Among the promising approaches, several investigations provided evidence of photodynamic therapy (PDT)‐induced stabilization and regression of atherosclerotic plaque. Significant development of PDT strategies improved its therapeutic outcome. This review addresses PDT's pertinence and major problems/challenges toward its translation to a clinical reality.

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“…Most cases of chest pain and almost all heart attacks are caused by atherosclerosis, a narrowing and hardening of the arteries that results from the accumulation of fatty deposits known as atheromas or plaques. 1 The plaques typically comprise cholesterol-containing low-density lipoproteins (LDLs), smooth muscle cells, brous tissue, and occasionally calcium. 2 Plaques are not deposited homogeneously in the arteries.…”

Section: A Introductionmentioning

confidence: 99%

Liquid biopsy of atherosclerosis using protoporphyrin IX as a biomarker

Silva

Sicchieri

Silva

et al. 2014

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Protoporphyrin IX (PPIX), a derivative of hematoporphyrin, can accumulate in rapidly growing tissues, including tumors and atherosclerotic plaques. The objective of this study is to employ PPIX fluorescence to detect the changes in blood caused by the formation of atheromatous plaques in arteries; this measurement can function as a liquid biopsy. For this purpose twenty four rabbits were randomly divided into groups: control group (CG)--fed with a normal diet, and an experimental group (EG)--fed with a hypercholesterolemic diet (1% cholesterol). Blood samples were collected before (0 time) and after 22, 43, 64 days to measure biochemical factors. The aortas were removed after 22, 43 and 64 days to assess the atherosclerotic plaques. PPIX was extracted from the blood and fluorescence was measured in the 550-750 nm range from samples that were excited at 405 nm. Aminolevulinic acid (ALA) was administered intravenously to increase the PPIX fluorescence intensity in the arteries and consequently in the liquid biopsy of the atherosclerotic plaques. The results have shown that the PPIX fluorescence increased as the atheromatous plaques grew. The aorta fluorescence and the PPIX fluorescence increased in the animals in the experimental group that received ALA. PPIX that accumulates in atheromatous plaques transfers to the blood and can be analyzed by extracting porphyrin from total blood. Therefore, this method can aid in the early diagnosis of atherosclerosis with high sensitivity.

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New medicines and approaches to treatment of atherosclerosis

Cited by 7 publications

References 52 publications

Optical Characterization of an Intra-Arterial Light and Drug Delivery System for Photodynamic Therapy of Atherosclerotic Plaque

Optical Characterization of an Intra-Arterial Light and Drug Delivery System for Photodynamic Therapy of Atherosclerotic Plaque

Photodynamic therapy for the treatment of atherosclerotic plaque: Lost in translation?

Liquid biopsy of atherosclerosis using protoporphyrin IX as a biomarker

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