New medicinal properties of mangostins: Analgesic activity and pharmacological characterization of active ingredients from the fruit hull of Garcinia mangostana L.

Cui, Jihong; Hu, Wen; Cai, Zhanjun; Liu, Yingxue; Liu, Siyuan; Tao, Wucheng; Xiang, Hui

doi:10.1016/j.pbb.2009.12.021

Cited by 112 publications

(83 citation statements)

References 38 publications

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“…Most promising topical treatments of skin aging includes herbal extracts, vitamins and antioxidant food supplement, which have been accepted widely to scavenge free radicals from skin cells and to restore skin elasticity (Pinnell 2003). The crude ethanol extract of mangosteen peel, α-mangostin and γ-mangostin has been revealed to possess potent peripheral and central antinociceptive effects in mice, suggesting that xanthones from the mangosteen peel may be developed as novel analgesics and anti-inflammatory drugs (Cui et al 2010). Potential therapeutic applications of the bioactive substances from mangosteen peel have also been summarized .…”

Section: Antioxidant Activity Of Bioactive Compounds From Mangosteen mentioning

confidence: 99%

In vitro antioxidant properties of mangosteen peel extract

2012

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The growing interest in the replacement of synthetic food antioxidants by natural ones has fostered research on the screening of plant-derived raw materials for identifying new antioxidants. The special attention of research today is focused on inexpensive or residual sources from agricultural industries. Fruit peels as sources of powerful natural antioxidants are often the waste parts of various fruits from consumption and food industry. Among the fruit peels, mangosteen peel is an important source of natural phenolic antioxidants. The mangosteen peel contains various bioactive substances, i.e., phenolic acids and flavonoids, which possess biological and medicinal properties, especially antioxidant properties. The aim of this review, after presenting analytical techniques for determining in vitro antioxidant activity of mangosteen peel extract, is to summarize available data on the factors affecting antioxidant activity of mangosteen peel extract. In addition, the potential antioxidant activity of mangosteen peel extract, the bioactive compounds identified from mangosteen peel extract and their antioxidant activity are presented. Potential applications of the mangosteen peel extract in food, pharmaceutical and cosmetic products are also discussed.

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Section: Antioxidant Activity Of Bioactive Compounds From Mangosteen mentioning

confidence: 99%

In vitro antioxidant properties of mangosteen peel extract

2012

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“…Consistently, Mahabusarakam et al [45] reported that α-MG and its synthetic derivatives inhibited the decrease of α-tocopherol consumption in copper-induced LDL oxidation, and the structural modifications of α-MG differently affected the antioxidant activity: (i) substitution of C-3 and C-6 hydroxyl groups with aminoethyl increased the activity, and (ii) substitution of C-3 and C-6 hydroxyl groups with methyl, acetate, propanediol, or nitrile reduced the activity. There is substantial evidence supporting the capacity of α-MG to scavenge superoxide anion (O 2 -• ), hydroxyl radicals (OH·), and H 2 O 2 [46][47][48][49]. On the other hand, α-MG was shown to possess peroxynitrite (ONOO − ) scavenging activity using authentic and 3-morpholinosydnonimine-derived peroxynitrite methods [32,46].…”

Section: Antioxidant Activitymentioning

confidence: 99%

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2017

Planta Med

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“…O g ê n e r o G a r c i n i a ( o u R h e e d i a ) pertencente à Clusiaceae tem demonstrado pelos estudos fitoquímicos, ser possuidor de uma grande diversidade de compostos fenólicos como benzofenonas, xantonas e flavonóides (Delle Monache et al, 1983;Cui et al, 2010Cui et al, 1984. Muitos desses constituintes são princípios ativos com propriedades farmacológicas contra várias doenças (Braz-Filho et al, 1970;Delle Monache et al, 1983;1988;Cui et al, 2010;Murata et al, 2010;Pereira et al, 2010).…”

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Estudo farmacobotânico das folhas de Garcinia brasiliensis Mart. (Clusiaceae)

Santa-Cecília

Abreu

Silva³

et al. 2013

Rev. bras. plantas med.

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RESUMO:A espécie Garcinia brasiliensis Mart. (Clusiaceae), nativa da região Amazônica e cultivada em todo o território brasileiro, vem sendo bastante estudada devido seu potencial farmacológico, porém são escassos estudos que tratam da caracterização farmacobotânica desta espécie. Considerando as propriedades terapêuticas para tornar-se um medicamento fitoterápico, o presente trabalho teve como objetivos estudar a anatomia e histoquímica da folha e do pecíolo e elaborar dados macroscópicos e microscópicos que forneçam características marcantes para sua identificação além de dar subsídios para a análise farmacognóstica no controle de qualidade da droga vegetal. O material vegetal foi fixado e submetido às técnicas usuais de microscopia de luz e a testes histoquímicos. As folhas de G. brasiliensis são opostas, simples, descolores, forma elíptica com nervação peninérvia. As células epidérmicas, em vista frontal, apresentam contorno sinuoso e estômatos paracíticos somente na face abaxial. O mesofilo é dorsiventral, a nervura central apresenta contorno biconvexo e feixe vascular em forma de semi-arco fechado envolto por bainha esclerenquimática. Inclusões inorgânicas de cristais na forma de drusas e orgânicas representadas por compostos fenólicos e grãos de amidos estão dispersos ao longo de toda lâmina foliar e pecíolo. Observa-se com frequência a presença de canais secretores preenchidos por um conteúdo lipídico dispersos pelo parênquima fundamental e próximos aos feixes vasculares. Estes dados fornecem subsídios para o controle de qualidade da matéria-prima utilizada para a produção de fitoterápicos.Palavras-chave: bacupari, Garcinia brasiliensis, Clusiaceae, morfodiagnose ABSTRACT: Pharmacobotanical studies of Garcinia brasiliensis Mart. (Clusiaceae) leaves. The Garcinia brasiliensis Mart. (Clusiaceae) species, native of the Amazon region and cultivated throughout the Brazilian territory, has been widely studied due to its pharmacological potential, but there are few studies dealing with the pharmacobotanic characterization of this species. Considering the therapeutic properties in order to become an herbal medicine, the present paper had the purpose of studying the anatomical and histochemical characterization of the leaf and petiole, as well as producing macroscopic and microscopic data that provide important characteristics for its identification, in addition to providing subsidies for the pharmacognostical analysis in order to offer elements for the quality assurance of the drug. The botanical material was prepared through the usual optical and histochemical microtechniques. The leaves of G. brasiliensis are simple, opposed, colorless, and they show an elliptical shape. As seen from the front, the epidermal cells have a sinuous contour, and paracytic stomata occur on the low surface. The leaves are hipostomatic and dorsiventral with heterogeneous mesophile. The mesophile is dorsiventral, the central midrib shows a biconvex contour and vascular system in a semi-closed arch shape surrounded by a sclerenchymatic...

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New medicinal properties of mangostins: Analgesic activity and pharmacological characterization of active ingredients from the fruit hull of Garcinia mangostana L.

Cited by 112 publications

References 38 publications

In vitro antioxidant properties of mangosteen peel extract

In vitro antioxidant properties of mangosteen peel extract

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Estudo farmacobotânico das folhas de Garcinia brasiliensis Mart. (Clusiaceae)

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