New medications for the treatment of acne

Abstract

Several new medications, both with novel molecules and modified delivery systems, have been developed for the treatment of acne vulgaris. Trifarotene 0.005% cream, tretinoin 0.05% lotion, and tazarotene 0.045% lotion expand topical retinoid options while minocycline 4% foam and systemic sarecycline provide new antibiotic choices for patients. Clascoterone 1% cream is a first in class topical antiandrogen recently FDA approved for acne. This review provides an update on these medications, including their mechanism of action, clinical data, and where they currently fit in the acne treatment algorithm as well as practical application tips.

Treatment of Acne Vulgaris During Pregnancy and Lactation: A Narrative Review

“…There are currently no data on the safety of clascoterone during human pregnancy and lactation. Some sources advise avoiding clascoterone, while others suggest clascoterone is likely safe because of minimal systemic absorption and rapid metabolism to cortexolone [ 61 , 62 ]. Due to uncertainty of risks associated with clascoterone, alternative treatments should be considered for acne during pregnancy and lactation.…”