New mechanisms and the anti-inflammatory role of curcumin in obesity and obesity-related metabolic diseases

Shehzad, Adeeb; Ha, Taewook; Subhan, Fazli; Lee, Young-Sup

doi:10.1007/s00394-011-0188-1

Cited by 234 publications

(155 citation statements)

References 68 publications

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“…A separating medium was removed and the sediment was saved for measurement on a γ-counter. The activities of AR, G6PD, GPE and GS in the liver were measured spectrophotometrically using chemical kits according to syndrome [9,28]. Moreover, previous studies have reported that curcumin can resist oxidative stress in the liver of high-fat diet (HFD)-induced diabetic rat by increasing oxygen consumption and the activity of SOD, GSH and GPx [25,29,30].…”

Section: Methodsmentioning

confidence: 99%

Curcumin attenuates oxidative stress in liver in Type 1 diabetic rats

Xie

Zeng

et al. 2017

Open Life Sciences

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Abstract:We investigated the effect of curcumin on liver anti-oxidative stress in the type 1 diabetic rat model induced by streptozotocin (STZ). Experimental diabetic rats were induced by STZ intraperitoneally. All rats were fed for 21 days including three groups of control (NC), diabetic model (DC) and curcumin-treated (Cur, 1.5 g/kg by gavage). The results showed that curcumin-treatment significantly decreased the blood glucose and plasma malondialdehyde levels, but significantly increased the plasma superoxide dismutase, glutathione peroxidase and reduced glutathione levels. Curcumin treatment decreased the activity of aldose reductase, but increased the plasma glucose-6-phosphate dehydrogenase, glucose synthetase and glucose-polymerizing activities. Curcumin treatment significantly decreased the protein of protein kinase C (PKC) and poly ADP ribose polymerase (PARP) expression in the Cur group compared with the DC group. Moreover, the sorbitol dehydrogenase activity was significantly decreased and deterred glucose enters into the polyol pathway leading to an increased NADPH content in the Cur group compared with the DC group. Our data provides evidence that oxidative stress in diabetic rats may be attenuated by curcumin by inhibiting polyol pathway associated with down-regulated expression of PKC and PARP, as evidenced by both an increase the antioxidant enzymes levels and glycogen biosynthesis enzymes activities.

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Section: Methodsmentioning

confidence: 99%

Curcumin attenuates oxidative stress in liver in Type 1 diabetic rats

Xie

Zeng

et al. 2017

Open Life Sciences

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“…The interactions of curcumin with several signal transduction pathways should reverse insulin resistance, hyperglycemia, hyperlipidemia, and other inflammatory symptoms associated with obesity and metabolic diseases [59]. Nevertheless, studies in humans are needed to explore the effects of curcumin in the treatment and control of metabolic abnormalities linked to obesity because knowledge at this level is still scarce.…”

Section: Curcuminmentioning

confidence: 99%

Studies on Mechanistic Role of Natural Bioactive Compounds in the Management of Obesity An Overview

Alves¹

2012

TONUTRAJ

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Abstract:Obesity is recognised as a condition of low-grade chronic inflammation resulting from macrophage infiltration of adipose tissue and activation of inflammatory pathways by oxidative stress mechanisms that lead to the development of insulin resistance. Various natural bioactive compounds (NBCs) with anti-inflammatory and anti-oxidant effects may improve adipocyte dysfunction associated with metabolic syndrome. The present review focuses on the effects of phenolic compounds, n-3 long-chain polyunsaturated fatty acids (n-3 LC-PUFA) and lipoic acid (LA) on the pathophysiological mechanisms of obesity. In this review, a total of 120 studies were included, and data thus obtained reflect beneficial physiological effects of n-3 LC-PUFA, LA and different phenolic compounds, including kaempferol, luteolin, apigenin, quercetin, resveratrol, curcumin, catechins, phenolic acids, in the prevention and/or attenuation of metabolic disturbances associated with obesity. Additionally, information from clinical studies provides new insights for defining the doseresponse relationship of dietary compounds, necessary time of exposure and potential side effects of these NBCs in the treatment of obesity and indicates further study is needed to verify these relationships.

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“…and shilajeet (thick exudates of the mountain during summer season) from mineral origin have been selected for testing as antiaflatoxin and antioxidant activity. All the aforementioned drugs have been reported to possess antiinflammatory and antiobesity properties [8,9] . In addition, crude haridra has been reported to be antiallergic [10] ; chitrak to be hepatoprotective [11] ;…”

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confidence: 99%

A Novel Herbomineral Formulation Sahaj Vati as Shelf Life Enhancer of Nutraceuticals Based on Aflatoxin Inhibitory and Antioxidant Activity

Yadav¹,

Dwivedy²,

Chaudhary³

et al. 2017

ijps

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Yadav, et al.: Sahaj Vati a Herbomineral Product as Antiaflatoxin and AntioxidantThe present investigation deals with chemical standardization and aflatoxin inhibitory and antioxidant activity of a herbomineral formulation, sahaj vati prepared in two batches (batch I and II) by mixing shilajeet (thick exudates of the mountain during summer season), guggul (Commiphora mukul (stocks) hook.), haridra (Curcuma longa L) and chitrak (Plumbago zeylanica L) with levigation of Agnimantha kwatha (Premna mucronata L). Batch I was prepared by mixing shilajeet, guggul, haridra and chitrak in equal proportion (25% each by weight) while batch II comprised shilajeet (44.7%), guggul (44.7%), haridra (4.8%) and chitrak (5.8%) by weight. Sahaj vati II showed highest (96%) inhibition of aflatoxin production at concentration of 10 000 µg/ml. Suddha guggul exhibited strong antioxidant activity showing lowest IC 50 at concentration of 20.56 µg/ml. Based on these findings, the newly formulated herbomineral formulation could be recommended for value addition of nutraceuticals by enhancing their shelf life against lipid per oxidation and aflatoxin contamination.

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New mechanisms and the anti-inflammatory role of curcumin in obesity and obesity-related metabolic diseases

Cited by 234 publications

References 68 publications

Curcumin attenuates oxidative stress in liver in Type 1 diabetic rats

Curcumin attenuates oxidative stress in liver in Type 1 diabetic rats

Studies on Mechanistic Role of Natural Bioactive Compounds in the Management of Obesity An Overview

A Novel Herbomineral Formulation Sahaj Vati as Shelf Life Enhancer of Nutraceuticals Based on Aflatoxin Inhibitory and Antioxidant Activity

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