New macromolecular carriers for drugs. I. Preparation and characterization of poly(oxyethylene‐b‐isoprene‐b‐oxyethylene) block copolymer aggregates

Abstract

SYNOPSISThis work describes the formation of discrete micelles (= 0.1 pm) from ABA poly-(oxyethylene-b-isoprene-b-oxyethylene) block copolymers in water. An efficient labeling of the micelles by polymerization of [ 14C] -styrene within the hydrophobic core is also described. These micellar nanoparticles are being considered as promising materials for controlled release and/or site-specific drug delivery systems. In experimental animals the micelles remained in circulation with a half-life in excess of 50 h. Our results demonstrate the advantages of using block copolymers for the preparation of "perfect" biocompatible surfaces such as are required for well-tolerated, long-circulating particulate drug carriers.

Unimolecular micelles: Synthesis and characterization of amphiphilic polymer systems

“…Samples (ϳ 5-10 mg/mL) were dissolved in either CDCl 3 , DMSO-d 6 , or D 2 O, with the solvent used as an internal reference. IR spectra were recorded on a Mattson Series spectrophotometer by solvent casting samples onto a KBr pellet.…”

Aggregation Behavior of Polystyrene/Poly(acrylic acid) Heteroarm Star Copolymers in 1,4-Dioxane and Aqueous Media

“…[7][8][9][10][11][12] The majority of research has been devoted to ionic diblock and triblock copolymers in aqueous environments, [13 -16] in organic solvents [17 -19] and in aqueous/ organic solvent mixtures. [20 -23] The extreme incompatibility between the ionic and hydrophobic blocks results in a strong driving force for microphase separation.…”

Self‐Assembly of Poly(γ‐benzyl L‐glutamate)‐graft‐Poly(ethylene glycol) and Its Mixtures with Poly(γ‐benzyl L‐glutamate) Homopolymer

“…That is to say, the aggregation of PBLG chains makes the PBLG homopolymer and PBLGgraft-PEG assemble to form polymeric micelles with the PBLG chains of both homopolymer and graft copolymer as the interior of the micelles surrounded by PEG chains. PBLG-PEG block copolymer as described by Cho et al [8,15] Figure 4b gives an example of the morphology of the micelles based on the mixture of PBLG-graft-PEG and PBLG homopolymer. Some micelles change from a spindly shape to a cylindrical shape, while the length of the micelles remains almost the same on the whole.…”

“…[1] The self-assembly of amphiphilic molecules has received much attention both experimentally [2,3] and theoretically. [4][5][6] The nanoscale structures possess a range of potential applications such as catalysis, [7] drug delivery, [8] nanoreactors etc. [9] Recently, much interest has been focused on the selfassembly behavior of the block copolymers composed of polypeptide segments and hydrophilic polymer chains.…”