Unimolecular micelles: Synthesis and characterization of amphiphilic polymer systems

Star-Shaped Drug Carriers for Doxorubicin with POEGMA and POEtOxMA Brush-like Shells: A Structural, Physical, and Biological Comparison

“…46 The results obtained within this study confirm the formation of unimers even for [PCL 18 -b-POEtOx 4 MA] 4 polymers with a rather short shell segment. However, the HLB for these systems, according to Uhrich et al, 47 corresponds to the value observed previously for [PCL 18 -b-POEG 9 MA] 4 polymers (Figure 2b). 18 These results confirm the principal applicability of the HLB to different polymer classes on the one hand and support that a HLB value of 0.8 is sufficient to stabilized unimers of star-shaped block copolymers with a brush-like shell in aqueous solution on the other hand.…”

Poly(triazolyl methacrylate) glycopolymers as potential targeted unimolecular nanocarriers

“…For example, Uhrich and co-workers utilised surface tension measurements to prove that the encapsulation of hydrophobic lidocaine molecules into mucic acidfatty acids-PEG branched polymers was caused by individual unimolecular micelles. 54 McCormick's group showed that random copolymers with selected molar ratios of 2-acrylamido-2-methylpropane sulfonic acid (AMPS) and n-dodecyl acrylamide (DDAM) possessed unimolecular micellar features, and, similar to what was observed in our work, induced a continuous decrease of surface tension in the range of concentrations investigated (up to 10 mg mL −1 ). 27 In terms of structure-function relationships, 4-arm star (2) MAN induced a larger decrease in surface tension compared to its linear counterpart (1) MAN , 66.5 vs. 70.2 mN m −1 at the highest concentration tested (5.0 mg mL −1 ), respectively ( Fig.…”

Surface‐active and associative properties of ionic polymeric surfactants based on carboxymethylcellulose

“…observed in all the other RO‐CMC derivatives (Tables 2 and 4) suggested the existence of intermolecular associations, however, intramolecular associations are likely to exist, too. These derivatives displayed low but distinct surface activity indicating that both phenomena occurred simultaneously, similarly as reported for others amphiphilic polysacharides [46, 47]. It has to be noted that also the associative properties of the RO‐CMC derivatives might be affected by the above mentioned composition and distribution of the acyl substituents.…”

“…Such behavior was reported previously for other hydrophobically modified anionic polysaccharides [36, 44, 45]. As polymeric surfactants establishing exclusively intramolecular associations display no “c.m.c.‐like” critical concentration [46], the different critical concentrations (c.m.c. and c.a.c.)…”