New lipophenols prevent carbonyl and oxidative stresses involved in macular degeneration

Abstract

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Bioactive Compounds in Edible Oils and Their Role in Oxidative Stress and Inflammation

“…The biological activity of lipophenols has been assessed in in vitro assays, frequently in non-cellular system, and only few studies have been performed in vivo in experimental animals. The antioxidant activity is a radical scavenging activity, even if the conjugation with FA frequently causes a decrease in the antioxidant properties of phenol, depending on the type of FA and on the phenol site of esterification (Moine et al, 2021). N-acyl dopamine and N-acyl-vanillylamines derivatives (containing a phenolic moiety), have also been shown to inhibit NO, IL-1β, IL-6, and TNF-α production, an effect that was dependent on the nature of FA with major effect for FA with a ketone group, then PUFA, MUFA, and saturated FA (Dang et al, 2011), suggesting a minor role for the phenolic moiety.…”

Distribution of tyrosol fatty acid esters in the gastrointestinal tracts of mice and their hydrolysis characteristics by gut microbiota

“…3 Phenolic lipids also have a variety of health benefits, and may be used as potential ingredients in functional foods. Currently, considerable research indicates that phenolic lipids have multiple health benefits with anti-inflammatory, [4][5][6] hyperglycemic, 7 antioxidant, [8][9][10] anticarbonyl stress 11 and antimicrobial activities. [12][13][14] However, little is known about the digestive absorption and metabolism of phenolic lipids, which is the major constraint on their application in functional foods.…”

Synthesis of Fatty Acid Bioconjugates and Related Derivatives

“…Synthesis of an isopropylated resveratrol lipophenol. [25] tion at the 7-position using toxic PhSH/N-methylpyrolidine conditions. [25] Subsequently, the diphenyldioxole group is replaced by TIPS groups to prevent PUFA instability during final deprotection step.…”