New knowledge of chondrocalcinosis

Calcium pyrophosphate dihydrate deposition disease: morphological and microanalytical features

“…The sections were carbon-coated and inserted into the specimen chamber of a JSM-3 5C scanning electronmicroscope equipped with a JEOL BEIS backscattered electron detector and a Kevex X-ray energy dispersive spectrometer (Cases 1-7). A Hitachi S520 microscope equipped with an S4548 high efficiency scintillator type backscatter detector and a Kevex 4460 delta class analyser was used for cases [8][9][10][11][12][13][14][15][16][17][18]. Secondary electron images and backscatter images (providing atomic number related as well as topographic contrast) of the crystals were photographed.…”

Diseases of connective tissue: a consensus

“…Ali (Ali, 1978) at page 191) argument still rages on the nature of the first alteration in joint function and in hyaline articular cartilage structure and composition that may precede the clinical disease (Gardner et al, 1978). It is certainly possible (Ali, 1978) that altered calcium hydroxyapatite metabolism can promote cartilage injury; the analogy with the accumulation in cartilage of the calcium pyrophosphate of chondrocalcinosis is very close (see P. Dieppe (Dieppe, 1978) at page 214). However, it seems to many that the progressive lesions of selected areas of hyaline cartilage are distinct from the non-progressive alterations that deform hip joints examined at necropsy (Byers et al, 1970).…”

Lysosomes and the connective tissue diseases

“…Long, needle-shaped crystals of monosodium urate monohydrate are found in the fluid from joints during acute attacks of gout (see J. T. Scott (Scott, 1978) at p. 205, and P. A. Dieppe (Dieppe, 1978) at p. 214). It was known in the last century that crystals occurred at the sites of gouty necrosis and that the subcutaneous injection into animals of microcrystals of various urates, xanthine, hypoxanthine, and creatinine-and even of calcium carbonate-provoked acute inflammatory responses copyright.…”