Diseases of connective tissue: a consensus

Gardner, D. L.

doi:10.1136/jcp.31.suppl_12.223

Cited by 6 publications

(2 citation statements)

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“…Benign connective and soft‐tissue neoplasms (CSTNs) develop from structures of the connective and subcutaneous tissue. These neoplasms are denominated in accordance with their cell of origin and, as benign tumors, do not invade or metastasize to other organs 1‐5 . Benign CSTNs of the oral and maxillofacial region are a heterogeneous group of adipocytic, neural, vascular, osseous, cartilaginous, muscular, fibrohistiocytic, fibroblastic, and myofibroblastic tumors 4,5 .…”

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confidence: 99%

“…These neoplasms are denominated in accordance with their cell of origin and, as benign tumors, do not invade or metastasize to other organs. [1][2][3][4][5] Benign CSTNs of the oral and maxillofacial region are a heterogeneous group of adipocytic, neural, vascular, osseous, cartilaginous, muscular, fibrohistiocytic, fibroblastic, and myofibroblastic tumors. 4,5 Some of these neoplasms are rare in head and neck region, whereas others have a preference for this region.…”

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Benign connective and soft‐tissue neoplasms of the oral and maxillofacial region: Cross‐sectional study of 1066 histopathological specimens

et al. 2020

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Background: Benign connective and soft-tissue neoplasms (CSTNs) are unusual in the head and neck region. The aim of the present study was to evaluate the demographic and clinicopathological features of these neoplasms. Methods: A cross-sectional study was conducted of cases diagnosed as benign CSTNs, with data collected from biopsy records. The chi-square test was used. A p-value <0.05 was considered indicative of statistical significance. Results: Among the 38 119 specimens, 1066 (2.79%) were benign CSTNs: 369 fibroblastic/myofibroblastic, 250 adipocytic, 179 vascular, 130 neural, 94 osseous/cartilaginous, 19 muscular, and two fibrohistiocytic. Most patients were female (62.8%) and white-skinned (45.8%). Mean age was 42 years. The tongue (25.2%) was the most affected site for extraosseous neoplasms. Conclusion: This study had the largest sample of benign oral and maxillofacial CSTNs. Although these tumors have similar clinical features, the characterization and differentiation detailed here may help clinicians with regards to the correct diagnosis. K E Y W O R D S connective tissue, diagnosis, neoplasms, oral pathology, soft-tissue neoplasms 1 | INTRODUCTION Benign connective and soft-tissue neoplasms (CSTNs) develop from structures of the connective and subcutaneous tissue. These neoplasms are denominated in accordance with their cell of origin and, as benign tumors, do not invade or metastasize to other organs. 1-5 Benign CSTNs of the oral and maxillofacial region are a heterogeneous group of adipocytic, neural, vascular, osseous, cartilaginous, muscular, fibrohistiocytic, fibroblastic, and myofibroblastic tumors. 4,5 Some of these neoplasms are rare in head and neck region, whereas others have a preference for this region. 6-55 Importantly, benign oral and maxillofacial CSTNs are associated with systemic diseases. Neural neoplasms are seen in neurofibromatosis, Noonan syndrome, and multiple endocrine neoplasia type 2B. 6 Gardner syndrome is related to bone tumors, especially osteomas, 7 and myofibromatosis is associated with myofibromas. 8 From the clinical standpoint, many oral and maxillofacial CSTNs have overlapping characteristics, which poses a challenge with regards to establishing the correct clinical diagnosis. These CSTNs usually appear as nodular or tumoral, painless, slow-growing, pink lesions

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Benign connective and soft‐tissue neoplasms of the oral and maxillofacial region: Cross‐sectional study of 1066 histopathological specimens

et al. 2020

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Clinical spectrum of fascial inflammation

1982

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The diverse clinical manifestations of fascial inflammation are reviewed including the entities of eosinophilic fasciitis, fascial inflammation in association with connective tissue diseases, fibrositis, nodular fasciitis, and necrotizing fasciitis. The neuromuscular clinician is encouraged to consider the possibility of fascial inflammation when evaluating patients with painful, aching extremities. A simple technique for including a fascial specimen when performing a routine muscle biopsy is described.

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Demonstration of fibronectin in human articular cartilage by an indirect immunoperoxidase technique

et al. 1982

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Fresh frozen tissue sections of human articular cartilage was treated without and with human testicular hyaluronidase (2 x 10(6) units/l) for 60 min at 37 degrees C and stained by the indirect immunoperoxidase technique with rabbit antihuman fibronectin. The rabbit antihuman fibronectin was purified by affinity chromatography on human fibronectin-Sepharose. Fibronectin was only found on the acellular surface of the articular cartilage in tissue sections not treated with hyaluronidase. In this surface layer, probably identical to "lamina splendens", the arrangement of fibronectin was as a membrane. No collagen was seen in this area by van Gieson staining. No staining for fibronectin was found in the cartilage matrix or in the chondrocytes. Treatment of the cartilage tissue with hyaluronidase resulted in visualization of high amount of fibronectin in the cartilage matrix, with the highest intensity around the chondrocytes. The staining of the acellular surface layer of the articular cartilage was identical with the results obtained without hyaluronidase treatment. These results indicate that articular cartilage is rich in fibronectin probably in complex with hyaluronic acid, and that the chondrocytes produce fibronectin in situ. It also demonstrates the steric hindrance of hyaluronic acid aggregates in diffusion of the antibody and the value of hyaluronidase treatment of tissue before demonstration of fibronectin.

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Diseases of connective tissue: a consensus

Cited by 6 publications

References 72 publications

Benign connective and soft‐tissue neoplasms of the oral and maxillofacial region: Cross‐sectional study of 1066 histopathological specimens

Benign connective and soft‐tissue neoplasms of the oral and maxillofacial region: Cross‐sectional study of 1066 histopathological specimens

Clinical spectrum of fascial inflammation

Demonstration of fibronectin in human articular cartilage by an indirect immunoperoxidase technique

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