New Isoquinoline Alkaloids from Paraphaeosphaeria sporulosa F03, a Fungal Endophyte Isolated from Paepalanthus planifolius

Amorim, Marcelo R. de; Paz, Tiago Antunes; Pinto, Luciano da Silva; Hilário, Felipe; Zanini, Camila Lima; Aguiar, Anna Caroline Campos; Silva, Débora E. S.; Furlan, Maysa; Güido, Rafael Victório Carvalho; Bauab, Taís Maria; Netto, Adelino Vieira de Godoy; Santos, Lourdes Campaner dos

doi:10.1055/a-1706-4642

Cited by 3 publications

(1 citation statement)

References 41 publications

(59 reference statements)

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“…El-Sayed et al optimized the biological process of Astragalus endophyte and tested its anticancer activity [ 1 ]. Amorim et al isolated antioxidant compounds from endophytic fungi of Luo Han Guo [ 2 ]. Kma et al identified the active metabolites of Luo Han Guo endophytic fungi, and verified its anti-inflammatory and analgesic effects through experiments [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Endophytic Fungi and Secondary Metabolites of Rehmannia Glutinosa Based on Traditional Chinese Medicine Fingerprints

Geng

2022

Contrast Media & Molecular Imaging

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Research on the active components of medicinal plants has always been the focus of research, and research on the active components of medicinal plant endophytic fungi and their secondary metabolites has also attracted widespread attention. Endophytic fungi of medicinal plants are widely distributed and are ubiquitous in various biological groups in nature. Rehmannia glutinosa contains a variety of active ingredients, which are regarded as the top grade of Chinese medicinal materials. It is of certain significance to study endophytic fungi and their metabolites of Rehmannia glutinosa. In this paper, endophytic fungi and their secondary metabolites of Rehmannia glutinosa were studied using fingerprint technology, which initially understands the diversity of endophytic fungi in Rehmannia glutinosa. In this paper, the roots and leaves of Rehmannia glutinosa were used as experimental materials. The fungi were cultured in the medium, the fungi were isolated and purified by the tissue block method, the fungal growth of Rehmannia glutinosa in different parts was determined, and the types of endophytic fungi were identified by microscopic identification and fingerprinting. The isolated strains were tested for biological activity using oryza oryzae spores, and highly active strains were screened. Fermentation products of endophytic fungi were separated and purified by chromatography, and the structure of the compounds was identified by nuclear magnetic resonance spectroscopy. Through the above studies, the population structure of endophytic fungi of Rehmannia glutinosa was determined, 3 highly active strains were found, and the structures of 7 endophytic fungi metabolites were identified, of which 3 were newly discovered compounds.

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Section: Introductionmentioning

confidence: 99%

Endophytic Fungi and Secondary Metabolites of Rehmannia Glutinosa Based on Traditional Chinese Medicine Fingerprints

Geng

2022

Contrast Media & Molecular Imaging

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Biologically active isoquinoline alkaloids covering 2019–2022

Wang,

Qin,

Jing

et al. 2024

Bioorganic Chemistry

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First report of Paraphaeosphaeria angularis as endophyte in sugarcane (Saccharum officinarum) from India

Malarvizhi¹,

Murali

Kumaresan

2022

Indian J Agri Sci

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Sugarcane (Saccharum officinarum L.) is considered to be an important crop that is utilized for production of molasses, sugar and ethanol. Thus, identifying microbes associated with this crop plant will give more insight into plant-microbe interaction. Further, there are limited studies on sugarcane fungal endophytes. Therefore, sugarcane leaves obtained from approximately 3 month old sugarcane plants growing in Puducherry were screened for the presence of fungal endophytes, during March 2022. The study conducted to identify fungal endophytes of sugarcane resulted in isolation of a sterile form which was identified as Paraphaeosphaeria angularis, an ascomycetous fungal species, based on sequencing of the internal transcribed spacer and the 5.8S rDNA region. Maximum Likelihood method was used to infer the evolutionary history. It is the first report of this fungus, as endophyte, from sugarcane host from India. The genus Paraphaeosphaeria is known to include plant pathogens, biocontrol agents and endophytic fungi. This study highlights the importance of studying and assigning taxa to the sterile forms especially from crop plants, since a species belonging to Paraphaeosphaeria, viz. P. michotii is reported as a pathogen from sugarcane from other countries. Further studies will reveal the potential of P. angularis as fungal species known to occur just as an endophyte or a capable pathogen.

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New Isoquinoline Alkaloids from Paraphaeosphaeria sporulosa F03, a Fungal Endophyte Isolated from Paepalanthus planifolius

Cited by 3 publications

References 41 publications

Endophytic Fungi and Secondary Metabolites of Rehmannia Glutinosa Based on Traditional Chinese Medicine Fingerprints

Endophytic Fungi and Secondary Metabolites of Rehmannia Glutinosa Based on Traditional Chinese Medicine Fingerprints

Biologically active isoquinoline alkaloids covering 2019–2022

First report of Paraphaeosphaeria angularis as endophyte in sugarcane (Saccharum officinarum) from India

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