New Isocoumarins and Related Metabolites from <i>Talaromyces flavus</i>

He, Junwei; Xu, Huai-Shuang; Yang, Li; He, Weiwei; Wang, Chuanxi; Feng, Lei; Lian, Yang-Yun; Sun, Bohang; Zhong, Guoyue

doi:10.1177/1934578x1601100627

Cited by 3 publications

(3 citation statements)

References 19 publications

(36 reference statements)

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“…Conventional separation and identification processes were time and plant material consuming [9,10,11,12,13], whereas the use of a rapid, efficient, and prescise method focused on identification chemical components was very important for TCMs. Over the past decade, UHPLC coupled with high-resolution mass spectrometry (HRMS) has become the prime tool for investigating the chemical profiling of TCMs, because of its advantages on the peak capacity, resolution, separation time, and detection sensitivity, all of which are suitable for addressing the complicated characteristics of the constituents in TCMs [14,15,16,17].…”

Section: Introductionmentioning

confidence: 99%

Rapid Analysis of the Chemical Compositions in Semiliquidambar cathayensis Roots by Ultra High-Performance Liquid Chromatography and Quadrupole Time-of-Flight Tandem Mass Spectrometry

Yang

Liu

2019

Molecules

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Semiliquidambar cathayensis Chang was a traditional medicinal plant and used to treat rheumatism arthritis and rheumatic arthritis for centuries in China with no scientific validation, while only 15 components were reported. Thus, a rapid, efficient, and precise method based on ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry (UHPLC-Q-TOF-MS/MS) was applied in both positive- and negative-ion modes to rapidly analysis the main chemical compositions in S. cathayensis for the first time. Finally, a total of 85 chemical compositions, including 35 alkaloids, 12 flavonoids, 7 terpenoids, 5 phenylpropanoids, 9 fatty acids, 7 cyclic peptides, and 10 others were identified or tentatively characterized in the roots of S. cathayensis based on the accurate mass within 5 ppm error. Moreover, alkaloid, flavonoid, phenylpropanoid, and cyclic peptide were reported from S. cathayensis for the first time. This rapid and sensitive method was highly useful to comprehend the chemical compositions and will provide scientific basis for further study on the material basis, mechanism and clinical application of S. cathayensis roots.

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Section: Introductionmentioning

confidence: 99%

Rapid Analysis of the Chemical Compositions in Semiliquidambar cathayensis Roots by Ultra High-Performance Liquid Chromatography and Quadrupole Time-of-Flight Tandem Mass Spectrometry

Yang

Liu

2019

Molecules

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“…96 Two new metabolites, talaflavuols B 368 and C 369 ( Figure 4G ) were isolated from the wetland soil-derived fungus Talaromyces flavus BYD07-13. 125 Aspereusin B 370 ( Figure 4G ) was isolated from the culture of Aspergillus terreus YIM PH30711. 93 Compounds Pyrenochaetayu 371 and compound Galinsogisoliyu 372 ( Figure 4G and H ) were successfully separated from the fermentation broth of Seltsamia galinsogisoli sp.…”

Section: Structure Types Of New Compounds Derived From Soil Fungimentioning

confidence: 99%

“… 132 Two new isocoumarin derivatives, talaisocoumarins A 413 and B 414 ( Figure 5A ), and one new related metabolite, talaflavuol A 415 ( Figure 5A ) were isolated from the wetland soil-derived fungus Talaromyces flavus BYD07-13. 125 Penicipyrans C 416 and D 417 ( Figure 5A ), were isolated from Penicillium raistrickii . 85 In research on novel secondary metabolites from microorganisms, two new 418 – 419 ( Figure 5B ) were derived from soil fungus Hypoxylon sp.…”

Section: Structure Types Of New Compounds Derived From Soil Fungimentioning

confidence: 99%

The Novel Compounds with Biological Activity Derived from Soil Fungi in the Past Decade

Zhang¹,

Li²,

Fan³

et al. 2022

DDDT

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The secondary metabolites isolated from soil fungi have received more and more attention, especially new compounds that exhibited good biological activities. In this review, a total of 546 new compounds are included in the relevant literature since 2011. The new compounds are isolated from soil fungi, We divided these compounds into seven categories, including alkaloids, terpenoids, steroids, ketones, phenylpropanoids, quinones, esters, lactones, etc. In addition, the biological activities and structure–activity relationships of these compounds have also been fully discussed. The activities of these compounds are roughly divided into eight categories, including anticancer activity, antimicrobial activity, anti-inflammatory activity, antioxidant activity, antiviral activity, antimalarial activity, immunosuppressive activity and other activities. Since natural products are an important source of new drugs, this review may have a positive guiding effect on drug screening.

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Plicatin C: A New Cinnamate Derivative from Mangrove-derived Fungus Aspergillus terreus DM62

Tian,

Chen,

Ding

et al. 2024

NPJ

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Background: Marine fungi have been proven to be a new arsenal for the discovery of valuable secondary metabolites. background: Marine fungi have been proved to be new arsenal for discovery of valuable secondary metabolites. The discovery of new bioactive secondary metabolites from Aspergillus sp. still possesses vast potential. Method:: Here, a new cinnamate derivative, plicatin C (1), together with 18 known compounds, was isolated from the solid and liquid state fermentations of a mangrove-derived fungus Aspergillus terreus DM62. Their chemical structures were elucidated by extensive spectroscopic analyses and optical rotations. Subsequently, the α-glucosidase inhibitory activity of isolated compounds was assessed to investigate their hypoglycemic activity Result:: Results showed that compounds 3, 6, and 8-10 exhibited stronger α-glucosidase inhibitory activities than acarbose at 400 μM. Meanwhile, ATP-citrate lyase (ACL) inhibitory activity of the isolated compounds was evaluated, and butenolide 3, with an IC50 value of 21.5 μM, was discovered with significant ACL inhibitory activity for the first time. Conclusion:: This study not only discovered a new cinnamate derivative but also found butenolides with potent ACL inhibitory activity, which is favorable to clarify their pharmacological mechanism in the treatment of metabolic disease.

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New Isocoumarins and Related Metabolites from Talaromyces flavus

Cited by 3 publications

References 19 publications

Rapid Analysis of the Chemical Compositions in Semiliquidambar cathayensis Roots by Ultra High-Performance Liquid Chromatography and Quadrupole Time-of-Flight Tandem Mass Spectrometry

Rapid Analysis of the Chemical Compositions in Semiliquidambar cathayensis Roots by Ultra High-Performance Liquid Chromatography and Quadrupole Time-of-Flight Tandem Mass Spectrometry

The Novel Compounds with Biological Activity Derived from Soil Fungi in the Past Decade

Plicatin C: A New Cinnamate Derivative from Mangrove-derived Fungus Aspergillus terreus DM62

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