New insights into thrombopoiesis in neonatal sepsis

Eissa, Deena Samir; El-Farrash, Rania A.

doi:10.3109/09537104.2012.696748

Cited by 18 publications

(18 citation statements)

References 31 publications

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“…Several authors documented organism-specific changes in thrombocytes [20,22,23]. Larger platelet size has also been associated with poor prognosis in neonatal sepsis [21,24], or septic shock in older age group [25].…”

Section: Discussionmentioning

confidence: 97%

Effect of Severe Maternal Iron Deficiency Anemia on Neonatal Platelet Indices

et al. 2015

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Section: Discussionmentioning

confidence: 97%

Effect of Severe Maternal Iron Deficiency Anemia on Neonatal Platelet Indices

et al. 2015

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“…14,27 Selama infeksi sistemik, hati menghasilkan substansi multifungsional termasuk sitokin hematopoiesis, salah satunya adalah TPO. Kadar TPO dalam sirkulasi penderita sepsis neonatorum lebih tinggi daripada neonatus normal, yang menunjukkan bahwa peningkatan konsenstrasi TPO dikarenakan destruksi platelet dan dilepaskannya cadangan TPO dari organel platelet atau karena terhambatnya reseptor megakariosit dan trombosit dan penurunan uptake dan metabolisme TPO.…”

Section: Pembahasanunclassified

“…Berbeda dengan penelitian terdahulu, median TPO pada sepsis neonatorum 1856 pg/mL. 14 Hal tersebut diduga karena populasi yang digunakan pada penelitian sebelumnya adalah neonatus berusia kurang dari 28 hari. Studi lain melaporkan peningkatan kadar TPO pada kasus sepsis neonatorum dengan median TPO 159 pg/mL dibandingkan dengan median TPO kontrol 57 pg/mL dengan peningkatan yang lebih tinggi terjadi pada sepsis berat dan syok septik (461 dan 522 pg/mL).…”

Section: Pembahasanunclassified

“…10 Berbagai usaha telah dilakukan untuk mendiagnosis dini sepsis neonatorum antara lain berdasarkan pemeriksaan profil hematologi dan TPO. 2,9,[11][12][13][14][15][16] Pada neonatus, produksi trombosit diatur oleh sitokin hematopoetik salah satunya yaitu trombopoietin (TPO) yang akan menstimulasi diferensiasi megakariosit menjadi trombosit matur. 12 Penelitian sebelumnya melaporkan peningkatan konsentrasi TPO plasma meningkat pada neonatus dan anak dengan sepsis 13,14 Karena identifikasi kuman yang sulit serta gambaran klinis yang tidak spesifik sehingga diagnosis sulit ditegakkan maka dipandang perlu untuk meneliti penanda yang dapat digunakan untuk mendiagnosis SNAD pada bayi tersangka sepsis.…”

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Perbandingan Profil Hematologi dan Trombopoietin sebagai Petanda Sepsis Neonatorum Awitan Dini

Wilar

Welly

Masloman

et al. 2017

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Latar belakang. Sepsis neonatorum memiliki gejala klinis yang tidak spesifik dan diagnosis dengan pemeriksaan kultur memerlukan waktu yang lama. Telah dilaporkan derajat sepsis bertambah seiring peningkatan kadar trombopoietin (TPO) sehingga TPO dapat dijadikan salah satu petanda derajat sepsis. Tujuan. Membandingkan profil hematologi dengan TPO sebagai petanda sepsis neonatorum awitan dini (SNAD). Metode. Studi potong lintang, dilakukan di Sub Bagian Neonatologi Bagian Ilmu Kesehatan Anak RSUP.Prof.Dr.R.D.Kandou, bulan November 2012 sampai April 2014. Didapatkan 103 neonatus tersangka SNAD. Diperbandingkan kadar profil hematologi (jumlah leukosit, jumlah trombosit dan IT rasio) dengan TPO. Hasil. Hasil uji diagnostik TPO dengan cut-off point 259 pg/mL pada SNAD diperoleh nilai sensitivitas 76,8% dan spesifisitas 24,4%; jumlah trombosit (T) sensitivitas 42,9% dan spesifisitas 87,2%; jumlah leukosit (L) sensitivitas 30,4% dan spesifisitas 87,3%; ITrasio (IT) sensitivitas 67,3% dan spesifisitas 50%; L+T diperoleh sensitivitas 58,9% dan spesifisitas 74,5%; L+IT sensitivitas 73,2% dan spesifisitas 46,8%; T+IT sensitivitas 78,6% dan spesifisitas 44,7% sedangkan L+T+IT sensitivitas 83,9% dan spesifisitas 34%. Kesimpulan. Sensitivitas dan spesifisitas TPO tidak lebih tinggi dibandingkan dengan profil hematologi sebagai petanda diagnosis SNAD. Sari Pediatri 2017;18(6):481-6Kata kunci: Jumlah trombosit, jumlah leukosit, IT-rasio, trombopoietin, tersangka sepsis, sepsis neonatorum awitan dini A Comparison of Hematology Profile and Thrombopoietin for Diagnosing Early-Onset Neonatal SepsisRocky Wilar, Silfy Welly, Nurhayati Masloman, Suryadi Tatura Background. Neonatal sepsis has not spesific clinical symptoms and diagnosing with blood culture takes a long time. It had been reported the severity of sepsis increased with increasing levels of thrombopoietin (TPO), that TPO can be used as a marker of the degree of sepsis. Objective. To compare the sensitivity and specificity of hematological profile and TPO for diagnosing early onset neonatal sepsis (EONS). Method. A cross-sectional study, was conducted in the Neonatology division Prof.Dr.R.D.Kandou general hospital from November 2012 to April 2014. There were 103 newborns with suspected EONS who fulfilled the inclusion criteria. Hematology profile (leukocyte-count, platelet-count and IT-ratio) and TPO measurements were performed. Results. TPO with the cut-off point of 259 pg/mL in EONS, obtained sensitivity 76.8% and specificity 24.4%. Sensitivity of Leukocytes (L) 30.4% and specificity 87.3%; sensitivity of platelet-count (T) 42.9% and specificity 87.2%; sensitivity of IT-ratio (IT) 67.3% and specificity 50%; L+T obtained sensitivity of 58.9% and specificity 74.5%; L+IT obtained sensitivity 73.2% and specificity 46.8%; T+IT obtained sensitivity 78.6% and specificity 44.7%, while L+T+IT obtained sensitivity 83.9% and specificity 34%. Conclusion. TPO has not higher sensitivity and spesificity than the hematological profile for early diagnosis of EONS. Sari Pediatri 2017;18(6):

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“…Thrombocytopenia is the most common hemostatic abnormality in sick newborn infants [1][2][3] . Although many conditions may be associated with neonatal thrombocytopenia, low platelet counts in the first few days of life are often caused by fetomaternal problems, whereas thrombocytopenia developing after the third day is usually secondary to sepsis or necrotizing enterocolitis.…”

Section: Introductionmentioning

confidence: 99%

Burden of Thrombocytopenia in Critically Ill Patients at a Tertiary Care Hospital

2018

JMPB

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Background; Neonatal thrombocytopenia is one of the commonest hematological abnormality encountered in neonatal intensive care unit. Though thrombocytopenia is prevalent it is often overlooked assuming it will resolve spontaneously. However, if it is not detected and managed properly can result in devastating complications. Objective; To determine the frequency of thrombocytopenia in sick neonates admitted in neonatal intensive care unit (NICU). Material and Methods; A total 282 newborns admitted to NICU of department of Pediatrics, Nishtar Hospital, Multan were included in this cross-sectional were enrolled, their blood samples were taken for estimation of platelet count to diagnose thrombocytopenia and all the data was analyzed by SPSS. Results; Of these 282 study cases, 198 (70.2 %) were male patients while 84 (29.8 %) were female patients. Mean age of our study cases was 5.18 ± 3.69 days. Of these 282 study cases, 85 (30.1 %) belonged to rural areas and 197 (69.9 %) belonged to urban areas. Of these 282 study cases, 187 (66.3%) mothers were illiterate while 95 (33.3%) were literate. Preterm birth was noted in 116 (41.1 %) of our study cases. Of these 282 study cases, 188 (66.7%) were born through vaginal deliveries while 94 (33.3%) by cesarean section. Mean duration of disease was 2.34 ± 1.10 days and 241 (85.5%) had disease duration up to 3 days. Mean platelet count of our study cases was 156575.24 ± 50250.53 mm 3 and thrombocytopenia was present in 104 (36.9%). Conclusion; High frequency of thrombocytopenia was observed in sick neonates in our study. Thrombocytopenia was significantly associated with age, residential status, maternal literacy, preterm births, mode of delivery and disease duration. All the clinicians treating such patients should regularly monitor platelet count of all the patients admitted to NICU for early diagnosis and timely management to save them further complications. This will not only decrease disease morbidity but will also reduce mortalities in these patients.

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New insights into thrombopoiesis in neonatal sepsis

Cited by 18 publications

References 31 publications

Effect of Severe Maternal Iron Deficiency Anemia on Neonatal Platelet Indices

Effect of Severe Maternal Iron Deficiency Anemia on Neonatal Platelet Indices

Perbandingan Profil Hematologi dan Trombopoietin sebagai Petanda Sepsis Neonatorum Awitan Dini

Burden of Thrombocytopenia in Critically Ill Patients at a Tertiary Care Hospital

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