New insights into the understanding of flow dynamics in an in vitro model for abdominal aortic aneurysms

Deplano, Valérie; Meyer, Clark A.; Guivier-Curien, Carine; Bertrand, Éric

doi:10.1016/j.medengphy.2012.08.010

Cited by 30 publications

(24 citation statements)

References 32 publications

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“…The flow rate boundary condition prescribed at the inlet and the pressure boundary conditions prescribed at each outlet are detailed in Figure 7. It is of note that the prescribed boundary conditions resulted in an asymmetry in the flow rates at the aortoiliac bifurcation, that is, a 60 : 40 split in flow rates between the right and left iliac arteries, respectively; however, this is consistent with the range of flow rates splits (80 : 20 to 50 : 50) considered by Deplano et al [35]. 572 P. APARÍCIO ET AL.…”

Section: Haemodynamic Modellingsupporting

confidence: 75%

“…It is of note that the prescribed boundary conditions resulted in an asymmetry in the flow rates at the aortoiliac bifurcation, that is, a 60 : 40 split in flow rates between the right and left iliac arteries, respectively; however, this is consistent with the range of flow rates splits (80 : 20 to 50 : 50) considered by Deplano et al . .…”

Section: Fluid–solid Growth Model For Aneurysm Evolutionmentioning

confidence: 99%

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Modelling the influence of endothelial heterogeneity on the progression of arterial disease: application to abdominal aortic aneurysm evolution

Aparicio

Mandaltsi

Boamah

et al. 2014

Numer Methods Biomed Eng

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We sophisticate a fluid-solid growth computational framework for modelling aneurysm evolution. A realistic structural model of the arterial wall is integrated into a patient-specific geometry of the vasculature. This enables physiologically representative distributions of haemodynamic stimuli, obtained from a rigid-wall computational fluid dynamics analysis, to be linked to growth and remodelling algorithms. Additionally, a quasistatic structural analysis quantifies the cyclic deformation of the arterial wall so that collagen growth and remodelling can be explicitly linked to the cyclic deformation of vascular cells. To simulate aneurysm evolution, degradation of elastin is driven by reductions in wall shear stress (WSS) below homeostatic thresholds. Given that the endothelium exhibits spatial and temporal heterogeneity, we propose a novel approach to define the homeostatic WSS thresholds: We allow them to be spatially and temporally heterogeneous. We illustrate the application of this novel fluid-solid growth framework to model abdominal aortic aneurysm (AAA) evolution and to examine how the influence of the definition of the WSS homeostatic threshold influences AAA progression. We conclude that improved understanding and modelling of the endothelial heterogeneity is important for modelling aneurysm evolution and, more generally, other vascular diseases where haemodynamic stimuli play an important role.

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Section: Haemodynamic Modellingsupporting

confidence: 75%

Section: Fluid–solid Growth Model For Aneurysm Evolutionmentioning

confidence: 99%

Modelling the influence of endothelial heterogeneity on the progression of arterial disease: application to abdominal aortic aneurysm evolution

Aparicio

Mandaltsi

Boamah

et al. 2014

Numer Methods Biomed Eng

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“…Particle image velocimetry (PIV) is an in vitro fluid dynamic measurement method that is commonly used for external and internal flow studies and is particularly useful for bio-fluid flow problems, such as flow in aneurysms. 9,13,16,29,38 Aside from vascular flow, it has also been employed for the investigation of respiratory studies. 14 The majority of flows of medical interest occur in highly complex internal channels.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of a Desktop 3D Printed Rigid Refractive-Indexed-Matched Flow Phantom for PIV Measurements on Cerebral Aneurysms

Ngoepe

Jermy

et al. 2019

Cardiovasc Eng Tech

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Purpose-Fabrication of a suitable flow model or phantom is critical to the study of biomedical fluid dynamics using optical flow visualization and measurement methods. The main difficulties arise from the optical properties of the model material, accuracy of the geometry and ease of fabrication. Methods-Conventionally an investment casting method has been used, but recently advancements in additive manufacturing techniques such as 3D printing have allowed the flow model to be printed directly with minimal post-processing steps. This study presents results of an investigation into the feasibility of fabrication of such models suitable for particle image velocimetry (PIV) using a common 3D printing Stereolithography process and photopolymer resin. Results-An idealised geometry of a cerebral aneurysm was printed to demonstrate its applicability for PIV experimentation. The material was shown to have a refractive index of 1.51, which can be refractive matched with a mixture of deionised water with ammonium thiocyanate (NH 4 SCN). The images were of a quality that after applying common PIV pre-processing techniques and a PIV cross-correlation algorithm, the results produced were consistent within the aneurysm when compared to previous studies. Conclusions-This study presents an alternative low-cost option for 3D printing of a flow phantom suitable for flow visualization simulations. The use of 3D printed flow phantoms reduces the complexity, time and effort required compared to conventional investment casting methods by removing the necessity of a multi-part process required with investment casting techniques.

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“…The AAA geometrical dimensions and shape were based on surgeons' recommendations to build an average anatomical model previously detailed in Deplano et al (2012). The geometry of the iliac bifurcation was asymmetric and based upon patient (Shah et al 1978).…”

Section: Geometrical Modelmentioning

confidence: 99%

“…This nonlinear behaviour has never been considered in the experimental study of AAA, and the most recent numerical simulations (Biasetti et al 2011) have been realised in AAA model with rigid wall. Therefore, this work deals with the analysis of the blood shear-thinning behaviour influence on the intra-AAA fluid dynamics in a compliant asymmetric model of AAA-included iliac bifurcation and physiological flow rate and pressure waveforms (Deplano et al 2012). …”

Section: Introductionmentioning

confidence: 99%

Influence of blood shear-thinning behaviour on flow dynamics in abdominal aortic aneurysmin vitrocompliant model

Deplano

Bailly

Bertrand

2012

Computer Methods in Biomechanics and Biomedical Engineering

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New insights into the understanding of flow dynamics in an in vitro model for abdominal aortic aneurysms

Cited by 30 publications

References 32 publications

Modelling the influence of endothelial heterogeneity on the progression of arterial disease: application to abdominal aortic aneurysm evolution

Modelling the influence of endothelial heterogeneity on the progression of arterial disease: application to abdominal aortic aneurysm evolution

Evaluation of a Desktop 3D Printed Rigid Refractive-Indexed-Matched Flow Phantom for PIV Measurements on Cerebral Aneurysms

Influence of blood shear-thinning behaviour on flow dynamics in abdominal aortic aneurysmin vitrocompliant model

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