New insights into the regulatory role of microRNA in tumor angiogenesis and clinical implications

Wang, Ye; Wang, Liya; Chen, Cheng; Chen, Xiaoyuan

doi:10.1186/s12943-018-0766-4

Cited by 133 publications

(122 citation statements)

References 134 publications

(135 reference statements)

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“…miRNA controls different aspects of BC angiogenesis and tumor progression by regulating apoptosis, proliferation, motility, energy metabolism, etc. More than forty miRNAs [48] were identified to be associated with tumor angiogenesis. Among the angiomiRs, miRNA-155, miRNA-153, miRNA-206, miRNA-467, miRNA-21, miRNA-34a and miRNA-126 respond to glucose level, miRNA-105, miRNA-206, miRNA-236 and miRNA-190 regulate metastasis, and miRNA-205, miRNA-206, miRNA-296, miRNA-34a and miRNA-98 control proliferation and thus control endothelial physiology and tumor angiogenesis ( Table 1).…”

Section: Mirna In Ec Vegf Signalingmentioning

confidence: 99%

Anti-Angiogenic Effects of Phytochemicals on miRNA Regulating Breast Cancer Progression

et al. 2020

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Several phytochemicals have been identified for their role in modifying miRNA regulating tumor progression. miRNAs modulate the expression of several oncogenes and tumor suppressor genes including the genes that regulate tumor angiogenesis. Hypoxia inducible factor-1 alpha (HIF-1α) signaling is a central axis that activates oncogenic signaling and acts as a metabolic switch in endothelial cell (EC) driven tumor angiogenesis. Tumor angiogenesis driven by metabolic reprogramming of EC is crucial for tumor progression and metastasis in many different cancers, including breast cancers, and has been linked to aberrant miRNA expression profiles. In the current article, we identify different miRNAs that regulate tumor angiogenesis in the context of oncogenic signaling and metabolic reprogramming in ECs and review how selected phytochemicals could modulate miRNA levels to induce an anti-angiogenic action in breast cancer. Studies involving genistein, epigallocatechin gallate (EGCG) and resveratrol demonstrate the regulation of miRNA-21, miRNA-221/222 and miRNA-27, which are prognostic markers in triple negative breast cancers (TNBCs). Modulating the metabolic pathway is a novel strategy for controlling tumor angiogenesis and tumor growth. Cardamonin, curcumin and resveratrol exhibit their anti-angiogenic property by targeting the miRNAs that regulate EC metabolism. Here we suggest that using phytochemicals to target miRNAs, which in turn suppresses tumor angiogenesis, should have the potential to inhibit tumor growth, progression, invasion and metastasis and may be developed into an effective therapeutic strategy for the treatment of many different cancers where tumor angiogenesis plays a significant role in tumor growth and progression.

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Section: Mirna In Ec Vegf Signalingmentioning

confidence: 99%

Anti-Angiogenic Effects of Phytochemicals on miRNA Regulating Breast Cancer Progression

et al. 2020

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“…It has been estimated that cancer cells can only reach a maximum volume of 1-2 mm 3 in the absence of a vascular system [110]. In order for tumors to proliferate and metastasize, angiogenesis must first take place, and miRNAs have been described to regulate this process [111][112][113]. Lin et al observed that miR-30d promotes angiogenic proliferation and migration, and enhances the ability of PCa cells to recruit endothelial cells via myosin phosphatase targeting subunit 1 (MYPT1)/c-JUN/VEGF-A pathway (Fig.…”

Section: Mirnas In Tumor Microenvironmentmentioning

confidence: 99%

microRNAs identified in prostate cancer: Correlative studies on response to ionizing radiation

et al. 2020

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As the most frequently diagnosed non-skin cancer in men and a leading cause of cancer-related death, understanding the molecular mechanisms that drive treatment resistance in prostate cancer poses a significant clinical need. Radiotherapy is one of the most widely used treatments for prostate cancer, along with surgery, hormone therapy, and chemotherapy. However, inherent radioresistance of tumor cells can reduce local control and ultimately lead to poor patient outcomes, such as recurrence, metastasis and death. The underlying mechanisms of radioresistance have not been fully elucidated, but it has been suggested that miRNAs play a critical role. miRNAs are small non-coding RNAs that regulate gene expression in every signaling pathway of the cell, with one miRNA often having multiple targets. By fine-tuning gene expression, miRNAs are important players in modulating DNA damage response, cell death, tumor aggression and the tumor microenvironment, and can ultimately affect a tumor's response to radiotherapy. Furthermore, much interest has focused on miRNAs found in biofluids and their potential utility in various clinical applications. In this review, we summarize the current knowledge on miRNA deregulation after irradiation and the associated functional outcomes, with a focus on prostate cancer. In addition, we discuss the utility of circulating miRNAs as non-invasive biomarkers to diagnose, predict response to treatment, and prognosticate patient outcomes.

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“…Histone acetylase overexpression, which catalyzes the removal of acetyl groups on the tail of histones, is another mechanism of transcriptional repression that leads to chromatin remodeling and genome instability in lung cancer [62]. miRNAs play important roles in different cellular processes including cell development and proliferation, differentiation, growth control, and apoptosis [9,11]. It was shown that miRNAs can regulate the expression of at least 30% of genes that control various biological functions [63,64].…”

Section: Epigenetic Factors In the Development Of Cancermentioning

confidence: 99%

“…Therefore, miRNA are involved in multiple biological processes, including gene regulation, cell development and proliferation, maintenance of cell differentiation, growth control, and apoptosis. Now it is well estimated that one-third of human genes are regulated by miRNAs and miRNAs play a key role in regulatory mechanisms of many cell function [10,11,63].…”

Section: Epigenetic Factors In the Development Of Cancermentioning

confidence: 99%

“…MiRNAs are a class of small single-stranded non-protein-coding RNAs that play important roles in different cellular processes including cell development and proliferation, differentiation, growth control, and apoptosis [8][9][10]. MiRNAs are generally composed of 18-25 nucleotides in length that are highly conserved in evolution and highly specific in tissues [11]. MiRNAs are involved in the regulation of target genes at the post-transcriptional level, miRNAs can covalently bind to complementary sequences of the 3 UTR region of the mRNA and thus inhibit translation.…”

Section: Introductionmentioning

confidence: 99%

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Radon Biomonitoring and microRNA in Lung Cancer

Bersimbaev

Pulliero

Bulgakova

et al. 2020

IJMS

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Radon is the number one cause of lung cancer in non-smokers. microRNA expression in human bronchial epithelium cells is altered by radon, with particular reference to upregulation of miR-16, miR-15, miR-23, miR-19, miR-125, and downregulation of let-7, miR-194, miR-373, miR-124, miR-146, miR-369, and miR-652. These alterations alter cell cycle, oxidative stress, inflammation, oncogene suppression, and malignant transformation. Also DNA methylation is altered as a consequence of miR-29 modification induced by radon. Indeed miR-29 targets DNA methyltransferases causing inhibition of CpG sites methylation. Massive microRNA dysregulation occurs in the lung due to radon expose and is functionally related with the resulting lung damage. However, in humans this massive lung microRNA alterations only barely reflect onto blood microRNAs. Indeed, blood miR-19 was not found altered in radon-exposed subjects. Thus, microRNAs are massively dysregulated in experimental models of radon lung carcinogenesis. In humans these events are initially adaptive being aimed at inhibiting neoplastic transformation. Only in case of long-term exposure to radon, microRNA alterations lead towards cancer development. Accordingly, it is difficult in human to establish a microRNA signature reflecting radon exposure. Additional studies are required to understand the role of microRNAs in pathogenesis of radon-induced lung cancer.

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New insights into the regulatory role of microRNA in tumor angiogenesis and clinical implications

Cited by 133 publications

References 134 publications

Anti-Angiogenic Effects of Phytochemicals on miRNA Regulating Breast Cancer Progression

Anti-Angiogenic Effects of Phytochemicals on miRNA Regulating Breast Cancer Progression

microRNAs identified in prostate cancer: Correlative studies on response to ionizing radiation

Radon Biomonitoring and microRNA in Lung Cancer

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