New Insights into the Regulation of Liver Inflammation and Oxidative Stress

Ferré, Natàlia; Clariá, J. J.

doi:10.2174/138955706778993049

Cited by 30 publications

(13 citation statements)

References 127 publications

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“…Because of this, we expect that the liberated gold ions are most likely present as gold cyanide AuCN molecules, i.e. Au + , since it is well known that macrophages can release cyanide and regulate oxygen tension and pH-value in their immediate surroundings (Ferre and Claria 2006). The following chemical process is believed to take place:…”

Section: Discussionmentioning

confidence: 99%

In vitro liberation of charged gold atoms: autometallographic tracing of gold ions released by macrophages grown on metallic gold surfaces

Larsen

Stoltenberg

Danscher

2007

Histochem Cell Biol

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The present study demonstrates that cultured macrophages are able to liberate gold ions from metallic gold surfaces, a process suggested to be called "dissolucytosis", in a way analogous to the release taking place when metallic implants are placed in a body. Using the ultra-sensitive autometallographic (AMG) technique, we demonstrate that murine macrophages grown on a surface of metallic gold liberate gold ions. Ultra-structural AMG reveals that the gold ions are located in an ultra-thin membrane-like structure, "the dissolution membrane", intervened between the macrophages and the metal surface. The presence of AMG silver enhanced gold nanoparticles in the dissolution membrane proves that the release of charged gold atoms takes place extracellularly. The dissolution membrane is most likely secreted and chemically controlled by the "dissolucytes", here macrophages, and the membrane is essential for the dissolution of metal implants and particles, which cannot be phagocytosed. Our findings support the notion that whenever a metallic gold surface is attacked by dissolucytes, gold ions are liberated and taken up by surrounding cells. As gold ions can suppress the inflammatory process, it is reasonable to expect that when dissolucytosis takes place in the living organism the liberated gold ions will cause local immunosuppression.

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Section: Discussionmentioning

confidence: 99%

In vitro liberation of charged gold atoms: autometallographic tracing of gold ions released by macrophages grown on metallic gold surfaces

Larsen

Stoltenberg

Danscher

2007

Histochem Cell Biol

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“…Therefore, KCs are not only relevant in HBV-and HCV-induced inflammation but also in the development of associated fibrosis and HCC. One study of KC depletion leading to attenuated liver injury (23) suggested an adverse net effect of liver macrophages, but the possible influence of macrophages will depend on their phenotypes and activation status.…”

Section: Macrophages Influence Liver Fibrosis and Cirrhosis And Cancermentioning

confidence: 99%

Macrophages in Hepatitis B and Hepatitis C Virus Infections

Heydtmann

2009

J Virol

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Hepatitis B virus (HBV) and hepatitis C virus (HCV) are major health burdens worldwide, with over 300 and 170 million people, respectively, infected. HBV, a DNA virus, and HCV, an RNA virus, are both hepatotropic, and both lead to hepatitis in many patients, with potentially fatal complications, including hepatocellular carcinoma. A high proportion of HCV-and HBV-infected patients develop chronic infections characterized by absent, weak, or narrowly focused T-cell responses (70). It is likely that early immune avoidance mechanisms contribute to the disturbed T-cell responses in combination with various other strategies reviewed elsewhere (7,28,31,36,70,82). The two viruses differ considerably in their interactions with the host immune system, but all current treatment protocols aimed at clearing either virus include alpha interferon (IFN-␣). This implies that the innate immune system is of pivotal importance in the development and maintenance of chronic infection versus viral clearance.Critical components of the innate immune response are liver macrophages. Here we highlight their key roles in both the favorable and adverse responses to HBV and HCV infections.

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“…Oxidative stress and inflammation are known to be associated with liver injury and development of liver diseases (Ferre and Claria, 2006; Dasarathy, 2008). Liver cells respond to exposure to drugs, chemicals and xenobiotics by activating intrinsic defense mechanisms aimed at neutralizing the insult and repairing the damage.…”

Section: Introductionmentioning

confidence: 99%

Hepatoprotective effects of S‐adenosylmethionine and silybin on canine hepatocytes in vitro

Hasenwinkel

Frondoza

2012

Animal Physiology Nutrition

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Inflammation and oxidative stress are associated with liver injury and development of liver disease. The transcription factors nuclear factor-kappa beta (NF-κB) and nuclear factor erythroid 2-related factor 2 (Nrf2) play critical roles in modulating liver injury and damage. Activation of NF-κB induces production of pro-inflammatory molecules including prostaglandin E2 (PGE2 ), interleukin-8 (IL-8) and macrophage chemotactic protein-1 (MCP-1). Nrf2 regulates genes controlling antioxidants. Our laboratory previously showed that hepatocytes, the primary functional cell type comprising liver tissue, respond to the cytokine interleukin-1 beta (IL-1β) by increased production of PGE2 , IL-8 and MCP-1. This increase is associated with nuclear translocation of NF-κB. In this study, we evaluated whether primary canine hepatocytes pre-treated with the combination of S-adenosylmethionine (SAMe; 30 and 2000 ng/ml) and silybin (SB; 298 ng/ml), agents with known anti-inflammatory and antioxidant properties, could attenuate IL-1β-induced inflammation and oxidative stress. The SAMe and SB combination reduced cytokine-induced PGE2 , IL-8 and MCP-1 production while also inhibiting NF-κB nuclear translocation. These changes were accompanied by increased antioxidant enzyme-reduced glutathione (GSH) comparable to control levels. The study shows for the first time that the SAMe and SB combination inhibits both inflammation and oxidative stress through two separate signalling pathways.

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New Insights into the Regulation of Liver Inflammation and Oxidative Stress

Cited by 30 publications

References 127 publications

In vitro liberation of charged gold atoms: autometallographic tracing of gold ions released by macrophages grown on metallic gold surfaces

In vitro liberation of charged gold atoms: autometallographic tracing of gold ions released by macrophages grown on metallic gold surfaces

Macrophages in Hepatitis B and Hepatitis C Virus Infections

Hepatoprotective effects of S‐adenosylmethionine and silybin on canine hepatocytes in vitro

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