We describe the public ESO near-IR variability survey (VVV) scanning the Milky Way bulge and an adjacent section of the mid-plane where star formation activity is high. The survey will take 1929 h of observations with the 4-m VISTA telescope during 5 years (2010-2014), covering ˜109 point sources across an area of 520 deg2, including 33 known globular clusters and ˜350 open clusters. The final product will be a deep near-IR atlas in five passbands (0.9-2.5 μm) and a catalogue of more than 106 variable point sources. Unlike single-epoch surveys that, in most cases, only produce 2-D maps, the VVV variable star survey will enable the construction of a 3-D map of the surveyed region using well-understood distance indicators such as RR Lyrae stars, and Cepheids. It will yield important information on the ages of the populations. The observations will be combined with data from MACHO, OGLE, EROS, VST, Spitzer, HST, Chandra, INTEGRAL, WISE, Fermi LAT, XMM-Newton, GAIA and ALMA for a complete understanding of the variable sources in the inner Milky Way. This public survey will provide data available to the whole community and therefore will enable further studies of the history of the Milky Way, its globular cluster evolution, and the population census of the Galactic Bulge and center, as well as the investigations of the star forming regions in the disk. The combined variable star catalogues will have important implications for theoretical investigations of pulsation properties of stars

We report the first results of a color-magnitude diagram survey of 25 candidate old LMC clusters. For almost all of the sample, it was possible to reach the turnoff region, and in many clusters we have several magnitudes of the main sequence. Age estimates based on the magnitude difference $\delta T_1$ between the giant branch clump and the turnoff revealed that no new old clusters were found. The candidates turned out to be of intermediate age (1-3 Gyr) We show that the apparently old ages as inferred from integrated UBV colors can be explained by a combination of stochastic effects produced by bright stars and by photometric errors for faint clusters lying in crowded fields. The relatively metal poor candidates from the CaII triplet spectroscopy also turned out to be of intermediate age. This, combined with the fact that they lie far out in the disk, yields interesting constraints regarding the formation and evolution of the LMC disk. We also study the age distribution of intermediate age and old clusters This homogeneous set of accurate relative ages allows us to make an improved study of the history of cluster formation/destruction for ages $>1$Gyr. We confirm previous indications that there was apparently no cluster formation in the LMC during the period from 3-8 Gyr ago, and that there was a pronounced epoch of cluster formation beginning 3 Gyrs ago that peaked at about 1.5 Gyrs ago. Our results suggest that there are few, if any, genuine old clusters in the LMC left to be found.Comment: LaTeX, to be published in Nov. 1997 Astronomical Journa

The pathophysiological background of decompensated cirrhosis is characterised by a systemic proinflammatory and pro-oxidant milieu that plays a major role in the development of multiorgan dysfunction. Such abnormality is mainly due to the systemic spread of bacteria and/or bacterial products from the gut and danger-associated molecular patterns from the diseased liver triggering the release of proinflammatory mediators by activating immune cells. The exacerbation of these processes underlies the development of acute-on-chronic liver failure. A further mechanism promoting multiorgan dysfunction and failure likely consists with a mitochondrial oxidative phosphorylation dysfunction responsible for systemic cellular energy crisis. The systemic proinflammatory and pro-oxidant state of patients with decompensated cirrhosis is also responsible for structural and functional changes in the albumin molecule, which spoil its pleiotropic non-oncotic properties such as antioxidant, scavenging, immune-modulating and endothelium protective functions. The knowledge of these abnormalities provides novel targets for mechanistic treatments. In this respect, the oncotic and non-oncotic properties of albumin make it a potential multitarget agent. This would expand the well-established indications to the use of albumin in decompensated cirrhosis, which mainly aim at improving effective volaemia or preventing its deterioration. Evidence has been recently provided that long-term albumin administration to patients with cirrhosis and ascites improves survival, prevents complications, eases the management of ascites and reduces hospitalisations. However, variant results indicate that further investigations are needed, aiming at confirming the beneficial effects of albumin, clarifying its optimal dosage and administration schedule and identify patients who would benefit most from long-term albumin administration.