New insights into the genetic history of Tunisians: Data from Alu insertion and apolipoprotein E gene polymorphisms

Bahri, Raoudha; Esteban, Esther; Moral, Pedro; Chaabani, Hassen

doi:10.1080/03014460701753729

Cited by 23 publications

(17 citation statements)

References 23 publications

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“…They are presented according to their geographic location in Figure 1. Their corresponding Alu insertion frequencies were obtained from studies already published (Stoneking et al, 1997;Bahri et al, 2008;El Moncer et al, 2010;González-Pérez et al, 2010).…”

Section: Methodsmentioning

confidence: 99%

Genetic Differentiation and Origin of the Jordanian Population: An Analysis ofAluInsertion Polymorphisms

Bahri

Moncer

Al‐Batayneh

et al. 2012

Genetic Testing and Molecular Biomarkers

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Section: Methodsmentioning

confidence: 99%

Genetic Differentiation and Origin of the Jordanian Population: An Analysis ofAluInsertion Polymorphisms

Bahri

Moncer

Al‐Batayneh

et al. 2012

Genetic Testing and Molecular Biomarkers

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“…Among these young Alu elements, approximately 25% have inserted so recently that they are polymorphic among different human population groups, families, or even individuals with respect to their presence or absence in the genome (Batzer and Deininger, 2002). Because Alu insertions are unique events that are identical bydescent, they have been useful in genetic mapping and population genetics studies (Batzer et al, 1994;Batzer and Deininger, 1991;Perna et al, 1992;Roy-Engel et al, 2001;Salem et al, 2003;Stoneking et al, 1997;Tishkoff et al, 2000) Alu markers have been used extensively for population structure and evolution, both at global (Bazter et al 1996;Romualdi et al 2002;Bamshad et al 2003) and regional levels (Majumder et al 1999;Comas et al 2000Comas et al , 2004de Pancorbo et al 2001;Nasidze et al 2001;Ennafaa et al 2006;Bahri et al 2008;Frigi et al 2010a). The objective of this study is to compare the genetic structure of some North African populations with respect to the other populations of North Africa, Western, Eastern and Central Europe, by using MDS and AMOVA methods.…”

Section: Would Havementioning

confidence: 99%

“…In order to ascertain population affinities based on Alu diversity, we compiled data obtained for the seven polymorphic loci from previously published papers (table 2 and figure 2) (Stoneking et al 1997;Comas et al 2000;Romualdi et al 2002;Garcia-Obregon et al 2006;Santovito et al 2007;Bahri et al 2008;Frigi et al 2010a). A non-metric multidimensional scaling (MDS) analysis was carried out (figure 3).…”

Section: Mds Analysismentioning

confidence: 99%

Human Alu Insertion Polymorphisms in North African Populations

et al. 2011

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Several features make Alu insertions a powerful tool used in population genetic studies: the polymorphic nature of many Alu insertions, the stability of an Alu insertion event and, furthermore, the ancestral state of an Alu insertion is known to be the absence of the Alu element at a particular locus and the presence of an Alu insertion at the site that forward mutational change. This study analyses seven Alu insertion polymorphisms in a sample of 297 individuals from the autochthonous population of Tunisia (Thala, Smar, Zarzis and Bou Salem) and Libya with the aim of studying their genetic structure with respect to the populations of North Africa, Western, Eastern and Central Europe. The comparative analyses carried out using the MDS and AMOVA methods reveal the existence of spatial heterogeneity, and identify four population groups. Study populations (Libya, Smar, ZarzisPre-print version. Visit

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“…This dissimilarity matrix was used to generate a MDS plot of population variation in two dimensions. For MDS analysis seven Alu insertion loci (ACE, APO, B65, D1, FXIIIB, PV92, and TPA25) were selected in order to provide the best comparison with data available in the literature (Stoneking et al, 1997;Comas et al, 2000;Bahari et al, 2008;Cherni et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

<i>Alu</i> insertion polymorphisms in four ethnic groups from northern Ivory Coast

Santovito

Cervella

Delpero

2014

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Patterns of genetic variation among geographically and ethnically diverse African populations have been under-represented in human genetics studies despite their importance for describing the evolutionary history of modern human populations. We conducted a study on 133 individuals, belonging to four northern Ivorian ethnic groups, based on the allele distribution of 11 Alu insertion loci, and compared the results with other African populations. All loci proved to be polymorphic in all ethnic groups, with the exception of HS2.43 and HS3.23, which were fixed for the absence and for the presence, respectively, of the Alu element. No significant departure from Hardy-Weinberg equilibrium was found among polymorphic loci, except for TPA25 loci in the Baoulé and Bété groups. Average heterozygosity (0.193 ± 0.042) was lower than that observed for the same loci in other African populations and the F ST value among ethnic groups for all loci was also notably low (0.0456). Multidimensional scaling analysis clearly separated Ivorians from other African samples, while in the neighbor-joining tree this population represented a basal branch of the tree, close to the hypothetical ancestral lineage. The picture emerging from our analyses reveals a conspicuous genetic homogeneity among Dioulà, Sénoufos, Boulè, and Bètè despite their sociocultural subdivision. Moreover, this northern Ivory Coast population, as a whole, turns out to be relatively isolated from the other African populations, possibly as a consequence of local patterns of population history, limited migration rates, and random genetic drift.

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New insights into the genetic history of Tunisians: Data from Alu insertion and apolipoprotein E gene polymorphisms

Cited by 23 publications

References 23 publications

Genetic Differentiation and Origin of the Jordanian Population: An Analysis ofAluInsertion Polymorphisms

Genetic Differentiation and Origin of the Jordanian Population: An Analysis ofAluInsertion Polymorphisms

Human Alu Insertion Polymorphisms in North African Populations

<i>Alu</i> insertion polymorphisms in four ethnic groups from northern Ivory Coast

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