New insights into the astonishing diversity of hormone functions

Westphal, Anika; Mrowka, Ralf

doi:10.1111/apha.13188

Cited by 2 publications

(2 citation statements)

References 19 publications

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“…The endocrine system is a network of secretory glands that secrete hormones and facilitate cellular communication [ 1 ]. These hormones are responsible for regulating almost every molecular, cellular and organ function in the body [ 2 ]. Hormonal imbalances can disrupt the endocrine system, impairing internal energy levels, metabolism, growth, development, reproduction, and response to injury, stress, and environmental variables [ 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

Development and experimental validation of 3D QSAR models for the screening of thyroid peroxidase inhibitors using integrated methods of computational chemistry

Rudresh,

Tater,

Barot

et al. 2024

Heliyon

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Section: Introductionmentioning

confidence: 99%

Development and experimental validation of 3D QSAR models for the screening of thyroid peroxidase inhibitors using integrated methods of computational chemistry

Rudresh,

Tater,

Barot

et al. 2024

Heliyon

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“…In mammals, the kidney participates in maintaining body fluid homeostasis, electrolyte concentrations and extracellular fluid volume [17]. The kidney performs homeostatic functions both independently and in concert with other organs, particularly under the control of the endocrine system via paracrine and autocrine pathways [18]. Dopamine, a catecholamine hormone, can be synthesized and secreted in the kidney apart from as a neurotransmitter in the brain [19–22].…”

Section: Introductionmentioning

confidence: 99%

Transcriptional analysis of renal dopamine-mediated Na+ homeostasis response to environmental salinity stress in Scatophagus argus

Zhou

Duan

et al. 2019

BMC Genomics

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Background To control the osmotic pressure in the body, physiological adjustments to salinity fluctuations require the fish to regulate body fluid homeostasis in relation to environmental change via osmoregulation. Previous studies related to osmoregulation were focused primarily on the gill; however, little is known about another organ involved in osmoregulation, the kidney. The salinity adaptation of marine fish involves complex physiological traits, metabolic pathways and molecular and gene networks in osmoregulatory organs. To further explore of the salinity adaptation of marine fish with regard to the role of the kidney, the euryhaline fish Scatophagus argus was employed in the present study. Renal expression profiles of S. argus at different salinity levels were characterized using RNA-sequencing, and an integrated approach of combining molecular tools with physiological and biochemical techniques was utilized to reveal renal osmoregulatory mechanisms in vivo and in vitro. Results S. argus renal transcriptomes from the hyposaline stress (0‰, freshwater [FW]), hypersaline stress (50‰, hypersaline water [HW]) and control groups (25‰) were compared to elucidate potential osmoregulatory mechanisms. In total, 19,012 and 36,253 differentially expressed genes (DEGs) were obtained from the FW and HW groups, respectively. Based on the functional classification of DEGs, the renal dopamine system-induced Na + transport was demonstrated to play a fundamental role in osmoregulation. In addition, for the first time in fish, many candidate genes associated with the dopamine system were identified. Furthermore, changes in environmental salinity affected renal dopamine release/reuptake by regulating the expression of genes related to dopamine reuptake ( dat and nkaα1 ), vesicular traffic-mediated dopamine release ( pink1 , lrrk2 , ace and apn ), DAT phosphorylation ( CaMKIIα and pkcβ ) and internalization ( akt1 ). The associated transcriptional regulation ensured appropriate extracellular dopamine abundance in the S. argus kidney, and fluctuations in extracellular dopamine produced a direct influence on Na + /K + -ATPase (NKA) expression and activity, which is associated with Na + homeostasis. Conclusions These transcriptomic data provided insight into the molecular basis of renal osmoregulation in S. argus . Significantly, the results of this study revealed the mechanism of renal dopamine system-induced Na + transport is essential in fish osmoregulation. ...

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New insights into the astonishing diversity of hormone functions

Cited by 2 publications

References 19 publications

Development and experimental validation of 3D QSAR models for the screening of thyroid peroxidase inhibitors using integrated methods of computational chemistry

Development and experimental validation of 3D QSAR models for the screening of thyroid peroxidase inhibitors using integrated methods of computational chemistry

Transcriptional analysis of renal dopamine-mediated Na+ homeostasis response to environmental salinity stress in Scatophagus argus

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