New insights into rotavirus vaccines

Mameli, Chiara; Fabiano, Valentina; Zuccotti, Gian Vincenzo

doi:10.4161/hv.20295

Cited by 10 publications

(7 citation statements)

References 69 publications

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“…In Isumi City, G1P [8] was dominant (70.3 ) before vaccine introduction, and G9P [8] type. In countries where RV vaccines were introduced earlier than in Japan, studies have reported that different distributions of RV genotypes were observed before and after introduction of the RV vaccine (10). However, whether this change is attributable to the protective effect of vaccines or to natural epidemiological changes remains controversial.…”

Section: Discussionmentioning

confidence: 99%

Changes in Rotavirus Genotypes before and after Vaccine Introduction: a Multicenter, Prospective Observational Study in Three Areas of Japan

et al. 2017

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Section: Discussionmentioning

confidence: 99%

Changes in Rotavirus Genotypes before and after Vaccine Introduction: a Multicenter, Prospective Observational Study in Three Areas of Japan

et al. 2017

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“…Symptoms begin abruptly and disappear within 3 -7 days [2]. The term rotavirus is derived from a Latin word "rota" meaning "wheel-like" appearance of the virus when viewed by electron microscope [3]. There are five species of this virus namely: A, B, C, D and E. Among these types, rotavirus A is the most common cause of more than 90% of the infections in humans and 20% fatality in young children [4].…”

Section: Introductionmentioning

confidence: 99%

Uptake of Rotavirus Vaccine and Factors That Contributed to Its Adoption and Acceptability by Parents/Guardians in Selected Communities of Ndola, Copperbelt Province, Zambia

Shachakanza¹,

Zulu²,

Maimbolwa³

2019

Health

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Rotavirus infection is recognized as a major cause of non-bacterial gastroenteritis infection affecting the stomach and intestinal tract in infants and young children worldwide leading to diarrhoea and vomiting. Most of the children would have had rotavirus infection by the time they are five years old. The disease is highly contagious and unpredictable as it can lead to dehydration due to severe loss of body fluid and consequently to death. World Health Organization recommended the use of two vaccines, RotaTeq R and Rotarix TM to be used in countries with high diarrhoea related mortality in under-five children. In Zambia rotavirus vaccine (Rotarix TM ) was rolled out to other parts of the country in its immunization program on 27th November 2013 after a successful pilot study in Lusaka in 2012 to reduce on diarrhoea caused by rotavirus infection among under-five children which had caused 9% of deaths. The objectives for this study were to establish uptake of rotavirus vaccine among under-fives and factors that shaped its adoption and acceptability at community level in Ndola, Zambia. Study design was cross sectional analytic community based which was conducted from 1st March 2017 to 28th September 2017 to compare factors that contributed to its uptake. Sample size consisted of 380 respondents who were parents/guardians to under-five children aged 3 -36 months residing in two homogenous selected communities. Purposive sampling was used to select study sites and respondents. This paper used triangulation method of data collection which included checklist, structured interview schedule and discussion guide tools. Health Statistical Package for Social Science (SPSS) was used for quantitative data analysis and Atlas.ti for qualitative data obtained from Focus Group Discussions (FGD) using hermeneutics theoretical frames to identify linkages and associations of variables. Results have shown that majority (85.3%) of under-fives received two recommended rotavirus vaccine (high uptake). Under-fives aged between 13 -18 months were 11.32 times more likely to receive high uptake of rotavirus vaccine than other age groups. Availability of rotavirus vaccine at health facilities (p = 0.035) contributed to its adoption and acceptability. In conclusion, availability of rotavirus vaccine at health facilities had an impact on its uptake and adoption.

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“…Rotavirus vaccination may have indirect benefits by herd immunity in unvaccinated population, including older children and adults. [25][26][27] This is a descriptive retrospective study to analyze the impact of rotavirus vaccination on the rate of hospitalizations due to AGE among children <2 y old in 2 areas of the province of Almer ıa, Spain, that could help to guide rotavirus vaccine policies from a public health point of view…”

Section: Introductionmentioning

confidence: 99%

Impact of vaccination uptake on hospitalizations due to rotavirus acute gastroenteritis in 2 different socioeconomic areas of Spain

Sánchez

Nogueira

Forte

et al. 2016

Human Vaccines & Immunotherapeutics

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Rotavirus is the leading cause of hospitalization due to acute gastroenteritis (AGE) in infants and toddlers. However, rotavirus vaccination has been associated with a decline in hospitalization rates due to rotavirus AGE. A descriptive retrospective study was conducted to analyze the impact of rotavirus vaccination on the rate of hospitalizations due to AGE among children ≤2 years old in 2 areas of the province of Almería, Spain. After eight years of rotavirus vaccination, rates of hospitalizations due to rotavirus AGE are diminished. This decline is closely related to vaccine coverage in the studied areas.

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New insights into rotavirus vaccines

Cited by 10 publications

References 69 publications

Changes in Rotavirus Genotypes before and after Vaccine Introduction: a Multicenter, Prospective Observational Study in Three Areas of Japan

Changes in Rotavirus Genotypes before and after Vaccine Introduction: a Multicenter, Prospective Observational Study in Three Areas of Japan

Uptake of Rotavirus Vaccine and Factors That Contributed to Its Adoption and Acceptability by Parents/Guardians in Selected Communities of Ndola, Copperbelt Province, Zambia

Impact of vaccination uptake on hospitalizations due to rotavirus acute gastroenteritis in 2 different socioeconomic areas of Spain

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